scholarly journals A Cytosolic Arabidopsis d-Xylulose Kinase Catalyzes the Phosphorylation of 1-Deoxy-d-Xylulose into a Precursor of the Plastidial Isoprenoid Pathway

2006 ◽  
Vol 142 (2) ◽  
pp. 441-457 ◽  
Author(s):  
Andréa Hemmerlin ◽  
Denis Tritsch ◽  
Michael Hartmann ◽  
Karine Pacaud ◽  
Jean-François Hoeffler ◽  
...  
Keyword(s):  
Isoprenoid Pathway ◽  
Xylulose Kinase

scholarly journals Structural and Kinetic Studies of Induced Fit in Xylulose Kinase from Escherichia coli

2007 ◽  
Vol 365 (3) ◽  
pp. 783-798 ◽  
Author(s):  
Eric Di Luccio ◽  
Barbara Petschacher ◽  
Jennifer Voegtli ◽  
Hui-Ting Chou ◽  
Henning Stahlberg ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Kinetic Studies ◽  
Induced Fit ◽  
Xylulose Kinase

Biochemistry of the non-mevalonate isoprenoid pathway

2011 ◽  
Vol 68 (23) ◽  
pp. 3797-3814 ◽  
Author(s):  
Tobias Gräwert ◽  
Michael Groll ◽  
Felix Rohdich ◽  
Adelbert Bacher ◽  
Wolfgang Eisenreich
Keyword(s):  
Isoprenoid Pathway

The Non-Mevalonate Isoprenoid Biosynthesis of Plants as a Test System for New Herbicides and Drugs against Pathogenic Bacteria and the Malaria Parasite

2000 ◽  
Vol 55 (5-6) ◽  
pp. 305-313 ◽  
Author(s):  
Hartmut K. Lichtenthaler ◽  
Johannes Zeidler ◽  
Jörg Schwender ◽  
Christian Müller
Keyword(s):  
Malaria Parasite ◽  
Pathogenic Bacteria ◽  
Higher Plants ◽  
Test System ◽  
Isoprenoid Biosynthesis ◽  
Mep Pathway ◽  
New Drugs ◽  
Security Measures ◽  
Isoprenoid Pathway ◽  
Parasite Plasmodium Falciparum

Higher plants and several photosynthetic algae contain the plastidic 1-deoxy-ᴅ-xylulose 5- phosphate / 2-C-methyl-ᴅ-erythritol 4-phosphate pathway (DOXP/MEP pathway) for isoprenoid biosynthesis. The first four enzymes and their genes are known of this novel pathway. All of the ca. 10 enzymes of this isoprenoid pathway are potential targets for new classes of herbicides. Since the DOXP/MEP pathway also occurs in several pathogenic bacteria, such as Mycobacterium tuberculosis, and in the malaria parasite Plasmodium falciparum, all inhibitors and potential herbicides of the DOXP/MEP pathway in plants are also potential drugs against pathogenic bacteria and the malaria parasite. Plants with their easily to handle DOXP/MEP-pathway are thus very suitable test-systems also for new drugs against pathogenic bacteria and the malaria parasite as no particular security measures are required. In fact, the antibiotic herbicide fosmidomycin specifically inhibited not only the DOXP reductoisomerase in plants, but also that in bacteria and in the parasite P. falciparum, and cures malaria-infected mice. This is the first successful application of a herbicide of the novel isoprenoid pathway as a possible drug against malaria.

Control of Rab5 and Rab7 Expression by the Isoprenoid Pathway

1998 ◽  
Vol 248 (3) ◽  
pp. 469-472 ◽  
Author(s):  
Chiara Laezza ◽  
Cecilia Bucci ◽  
Mariarosaria Santillo ◽  
Carmelo B. Bruni ◽  
Maurizio Bifulco
Keyword(s):  
Isoprenoid Pathway

Hypothalamic digoxin-mediated model for epileptogenesis

2003 ◽  
Vol 15 (3) ◽  
pp. 115-121 ◽  
Author(s):  
Ravi Kumar Kurup ◽  
Parameswara Achutha Kurup
Keyword(s):  
Dermatan Sulfate ◽  
Reductase Activity ◽  
Serum Magnesium ◽  
Seizure Disorder ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Membrane Composition ◽  
Isoprenoid Pathway ◽  
Rbc Membrane ◽  
Age Related

Background/aims:This study assessed the changes in the isoprenoid pathway and its metabolites in seizure disorder (ILAE classification – I generalized – idiopathic generalized epilepsy with age-related onset – epilepsy with generalized tonic clonic seizures on awakening) and the metabolic cascade produced by isoprenoid pathway dysregulation.Methods:The following parameters were assessed in seizure disorder: isoprenoid pathway metabolites, tyrosine and tryptophan catabolites, glycoconjugates metabolism and red blood cell (RBC) membrane composition.Results:There was elevation in plasma HMG-CoA reductase activity, serum digoxin and dolichol and a reduction in RBC membrane Na-K+ATPase activity, serum magnesium and ubiquinone levels. Serum tryptophan, serotonin, strychnine, nicotine and quinolinic acid were elevated while tyrosine, dopamine, morphine and norepinephrine were decreased. The total serum glycosaminoglycans and glycosaminoglycan fractions (except dermatan sulfate), the activity of glycosaminoglycans (GAG) degrading enzymes and glycohydrolases, carbohydrate residues of glycoproteins and serum glycolipids were elevated. Total serum cholesterol, LDL cholesterol and free fatty acids were increased while HDL cholesterol and triglycerides were unaltered. The concentration of membrane hexose, fucose, cholesterol and phospholipids in the RBC membrane decreased significantly but the total RBC membrane GAG was unaltered.Conclusions:Epileptogenesis could be due to a dysfunctional isoprenoidal pathway and paroxysmal hypothalamic digoxin hypersecretion.

scholarly journals Functional Gene Network of Prenyltransferases in Arabidopsis thaliana

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4556 ◽  
Author(s):  
Diana Kopcsayová ◽  
Eva Vranová
Keyword(s):  
Arabidopsis Thaliana ◽  
Amino Acid Level ◽  
Chain Elongation ◽  
Pathway Network ◽  
Isoprenoid Pathway ◽  
Prenyl Diphosphate ◽  
Mutant Complementation

Prenyltransferases (PTs) are enzymes that catalyze prenyl chain elongation. Some are highly similar to each other at the amino acid level. Therefore, it is difficult to assign their function based solely on their sequence homology to functional orthologs. Other experiments, such as in vitro enzymatic assay, mutant analysis, and mutant complementation are necessary to assign their precise function. Moreover, subcellular localization can also influence the functionality of the enzymes within the pathway network, because different isoprenoid end products are synthesized in the cytosol, mitochondria, or plastids from prenyl diphosphate (prenyl-PP) substrates. In addition to in vivo functional experiments, in silico approaches, such as co-expression analysis, can provide information about the topology of PTs within the isoprenoid pathway network. There has been huge progress in the last few years in the characterization of individual Arabidopsis PTs, resulting in better understanding of their function and their topology within the isoprenoid pathway. Here, we summarize these findings and present the updated topological model of PTs in the Arabidopsis thaliana isoprenoid pathway.

scholarly journals TheYTA7gene is involved in the regulation of the isoprenoid pathway in the yeastSaccharomyces cerevisiae

2009 ◽  
Vol 9 (3) ◽  
pp. 381-390 ◽  
Author(s):  
Klaudia Kuranda ◽  
Kariona Grabinska ◽  
Thierry Berges ◽  
Francis Karst ◽  
Veronique Leberre ◽  
...  
Keyword(s):  
Isoprenoid Pathway

scholarly journals Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate inEscherichia coli

FEBS Letters ◽  
2000 ◽  
Vol 473 (3) ◽  
pp. 328-332 ◽  
Author(s):  
Manuel Rodrı́guez-Concepción ◽  
Narciso Campos ◽  
Luisa Marı́a Lois ◽  
Carlos Maldonado ◽  
Jean-François Hoeffler ◽  
...  
Keyword(s):  
Genetic Evidence ◽  
Isopentenyl Diphosphate ◽  
Inescherichia Coli ◽  
Isoprenoid Pathway ◽  
Dimethylallyl Diphosphate
Sign in / Sign up

Export Citation Format

Share Document