scholarly journals Fatty Acid Hydroperoxides and H2O2 in the Execution of Hypersensitive Cell Death in Tobacco Leaves

2005 ◽  
Vol 138 (3) ◽  
pp. 1516-1526 ◽  
Author(s):  
Jean-Luc Montillet ◽  
Sangpen Chamnongpol ◽  
Christine Rustérucci ◽  
James Dat ◽  
Brigitte van de Cotte ◽  
...  
Keyword(s):  
Cell Death ◽  
Fatty Acid ◽  
Hypersensitive Cell Death ◽  
Tobacco Leaves ◽  
Fatty Acid Hydroperoxides

scholarly journals Involvement of Lipoxygenase-dependent Production of Fatty Acid Hydroperoxides in the Development of the Hypersensitive Cell Death induced by Cryptogein on Tobacco Leaves

1999 ◽  
Vol 274 (51) ◽  
pp. 36446-36455 ◽  
Author(s):  
Christine Rustérucci ◽  
Jean-Luc Montillet ◽  
Jean-Pierre Agnel ◽  
Christine Battesti ◽  
Béatrice Alonso ◽  
...  
Keyword(s):  
Cell Death ◽  
Fatty Acid ◽  
Hypersensitive Cell Death ◽  
Tobacco Leaves ◽  
Fatty Acid Hydroperoxides

scholarly journals A Caleosin-Like Protein with Peroxygenase Activity Mediates Aspergillus flavus Development, Aflatoxin Accumulation, and Seed Infection

2015 ◽  
Vol 81 (18) ◽  
pp. 6129-6144 ◽  
Author(s):  
Abdulsamie Hanano ◽  
Ibrahem Almousally ◽  
Mouhnad Shaban ◽  
Elizabeth Blee
Keyword(s):  
Fatty Acid ◽  
Aspergillus Flavus ◽  
Polyunsaturated Fatty Acid ◽  
Calcium Binding ◽  
Antioxidant Activities ◽  
Fungal Growth ◽  
Oxidation Reactions ◽  
Content Type ◽  
Fatty Acid Hydroperoxides

ABSTRACTCaleosins are a small family of calcium-binding proteins endowed with peroxygenase activity in plants. Caleosin-like genes are present in fungi; however, their functions have not been reported yet. In this work, we identify a plant caleosin-like protein inAspergillus flavusthat is highly expressed during the early stages of spore germination. A recombinant purified 32-kDa caleosin-like protein supported peroxygenase activities, including co-oxidation reactions and reduction of polyunsaturated fatty acid hydroperoxides. Deletion of the caleosin gene prevented fungal development. Alternatively, silencing of the gene led to the increased accumulation of endogenous polyunsaturated fatty acid hydroperoxides and antioxidant activities but to a reduction of fungal growth and conidium formation. Two key genes of the aflatoxin biosynthesis pathway,aflRandaflD, were downregulated in the strains in whichA. flavusPXG(AfPXG) was silenced, leading to reduced aflatoxin B1 productionin vitro. Application of caleosin/peroxygenase-derived oxylipins restored the wild-type phenotype in the strains in whichAfPXGwas silenced.PXG-deficientA. flavusstrains were severely compromised in their capacity to infect maize seeds and to produce aflatoxin. Our results uncover a new branch of the fungal oxylipin pathway and may lead to the development of novel targets for controlling fungal disease.

Inhibition of 5-lipoxygenase induces cell death in anti-inflammatory fatty acid-treated HL-60 cells

2004 ◽  
Vol 28 (5) ◽  
pp. 308-314 ◽  
Author(s):  
RC Gillis ◽  
BJ Daley ◽  
BL Enderson ◽  
MD Karlstad
Keyword(s):  
Cell Death ◽  
Fatty Acid ◽  
Anti Inflammatory
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