scholarly journals Nitric Oxide Acts as an Antioxidant and Delays Programmed Cell Death in Barley Aleurone Layers

2002 ◽  
Vol 129 (4) ◽  
pp. 1642-1650 ◽  
Author(s):  
Maria Veronica Beligni ◽  
Angelika Fath ◽  
Paul C. Bethke ◽  
Lorenzo Lamattina ◽  
Russell L. Jones
2015 ◽  
Vol 66 (10) ◽  
pp. 2869-2876 ◽  
Author(s):  
Irene Serrano ◽  
María C. Romero-Puertas ◽  
Luisa M. Sandalio ◽  
Adela Olmedilla

2018 ◽  
Vol 115 (18) ◽  
pp. 4672-4677 ◽  
Author(s):  
Seung-Hyun Lee ◽  
Jaesung Seo ◽  
Soo-Yeon Park ◽  
Mi-Hyeon Jeong ◽  
Hyo-Kyoung Choi ◽  
...  

Programmed cell death 5 (PDCD5) has been associated with human cancers as a regulator of cell death; however, the role of PDCD5 in the endothelium has not been revealed. Thus, we investigated whether PDCD5 regulates protein kinase B (PKB/AKT)-endothelial nitric oxide synthase (eNOS)–dependent signal transduction in the endothelium and affects atherosclerosis. Endothelial-specific PDCD5 knockout mice showed significantly reduced vascular remodeling compared with wild-type (WT) mice after partial carotid ligation. WT PDCD5 competitively inhibited interaction between histone deacetylase 3 (HDAC3) and AKT, but PDCD5L6R, an HDAC3-binding–deficient mutant, did not. Knockdown of PDCD5 accelerated HDAC3–AKT interaction, AKT and eNOS phosphorylation, and nitric oxide (NO) production in human umbilical vein endothelial cells. Moreover, we found that serum PDCD5 levels reflect endothelial NO production and are correlated with diabetes mellitus, high-density lipoprotein cholesterol, and coronary calcium in human samples obtained from the cardiovascular high-risk cohort. Therefore, we conclude that PDCD5 is associated with endothelial dysfunction and may be a novel therapeutic target in atherosclerosis.


PROTOPLASMA ◽  
2007 ◽  
Vol 232 (1-2) ◽  
pp. 97-108 ◽  
Author(s):  
I. Kołodziejek ◽  
J. Kozioł-Lipińska ◽  
M. Wałęza ◽  
J. Korczyński ◽  
A. Mostowska

Planta ◽  
2010 ◽  
Vol 232 (2) ◽  
pp. 325-335 ◽  
Author(s):  
Wenwen Ma ◽  
Wenzhong Xu ◽  
Hua Xu ◽  
Yanshan Chen ◽  
Zhenyan He ◽  
...  

2008 ◽  
Vol 133 (2) ◽  
pp. 449-457 ◽  
Author(s):  
Massimo Malerba ◽  
Nicla Contran ◽  
Mariagrazia Tonelli ◽  
Paolo Crosti ◽  
Raffaella Cerana

Plant Science ◽  
2021 ◽  
pp. 110988
Author(s):  
Junjun Huang ◽  
Ying Wang ◽  
Wenwen Liu ◽  
Xiaoyu Li ◽  
Rongzhi Han ◽  
...  

1999 ◽  
Vol 11 (6) ◽  
pp. 1033-1045 ◽  
Author(s):  
Paul C. Bethke ◽  
Jennifer E. Lonsdale ◽  
Angelika Fath ◽  
Russell L. Jones

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