Half-life measurement of short-lived Ru44+4494m using isochronous mass spectrometry

2017 ◽  
Vol 96 (3) ◽  
Author(s):  
Q. Zeng ◽  
M. Wang ◽  
X. H. Zhou ◽  
Y. H. Zhang ◽  
X. L. Tu ◽  
...  
2019 ◽  
Vol 986 ◽  
pp. 213-222 ◽  
Author(s):  
T.N. Szegedi ◽  
G.G. Kiss ◽  
I. Öksüz ◽  
T. Szücs ◽  
Gy. Gyürky ◽  
...  

2020 ◽  
Vol 58 (9) ◽  
pp. 1461-1468 ◽  
Author(s):  
Jean-Claude Alvarez ◽  
Pierre Moine ◽  
Isabelle Etting ◽  
Djillali Annane ◽  
Islam Amine Larabi

AbstractObjectivesA method based on liquid chromatography coupled to triple quadrupole mass spectrometry detection using 50 µL of plasma was developed and fully validated for quantification of remdesivir and its active metabolites GS-441524.MethodsA simple protein precipitation was carried out using 75 µL of methanol containing the internal standard (IS) remdesivir-13C6 and 5 µL ZnSO4 1 M. After separation on Kinetex® 2.6 µm Polar C18 100A LC column (100 × 2.1 mm i.d.), both compounds were detected by a mass spectrometer with electrospray ionization in positive mode. The ion transitions used were m/z 603.3 → m/z 200.0 and m/z 229.0 for remdesivir, m/z 292.2 → m/z 173.1 and m/z 147.1 for GS-441524 and m/z 609.3 → m/z 206.0 for remdesivir-13C6.ResultsCalibration curves were linear in the 1–5000 μg/L range for remdesivir and 5–2500 for GS-441524, with limit of detection set at 0.5 and 2 μg/L and limit of quantification at 1 and 5 μg/L, respectively. Precisions evaluated at 2.5, 400 and 4000 μg/L for remdesivir and 12.5, 125, 2000 μg/L for GS-441524 were lower than 14.7% and accuracy was in the [89.6–110.2%] range. A slight matrix effect was observed, compensated by IS. Higher stability of remdesivir and metabolite was observed on NaF-plasma. After 200 mg IV single administration, remdesivir concentration decrease rapidly with a half-life less than 1 h while GS-441524 appeared rapidly and decreased slowly until H24 with a half-life around 12 h.ConclusionsThis method would be useful for therapeutic drug monitoring of these compounds in Covid-19 pandemic.


2015 ◽  
Vol T166 ◽  
pp. 014009 ◽  
Author(s):  
X L Tu ◽  
B Mei ◽  
Y H Zhang ◽  
H S Xu ◽  
Yu A Litvinov ◽  
...  

Author(s):  
J. K. Hwang ◽  
A. V. Ramayya ◽  
J. H. Hamilton ◽  
D. Fong ◽  
C. J. Beyer ◽  
...  

2020 ◽  
Vol 101 (1) ◽  
Author(s):  
V. E. Iacob ◽  
J. C. Hardy ◽  
H. I. Park ◽  
M. Bencomo ◽  
L. Chen ◽  
...  
Keyword(s):  

2004 ◽  
Vol 93 (17) ◽  
Author(s):  
C. Vockenhuber ◽  
F. Oberli ◽  
M. Bichler ◽  
I. Ahmad ◽  
G. Quitté ◽  
...  

2018 ◽  
Vol 97 (3) ◽  
Author(s):  
A. A. Valverde ◽  
M. Brodeur ◽  
T. Ahn ◽  
J. Allen ◽  
D. W. Bardayan ◽  
...  
Keyword(s):  

Radiocarbon ◽  
1992 ◽  
Vol 34 (3) ◽  
pp. 436-446 ◽  
Author(s):  
Walter Kutschera ◽  
Irshad Ahmad ◽  
Michael Paul

We have performed a new determination of the half-life of 41Ca by measuring the specific activity of an enriched Ca material with known 41Ca abundance. We measured the activity via the 3.3-keV X-rays emitted in the electron capture decay of 41Ca, and the 41Ca abundance was measured by low-energy mass spectrometry. The result, t1/2 = (1.01 ± 0.10) × 105 yr, agrees with the recent ‘geological’ half-life of Klein et al., (1991), t1/2 = (1.03 ± 0.07) × 105 yr, and with the corrected value of Mabuchi et al. (1974), t1/2 = (1.13 ± 0.12) × 105 yr. We recommend the weighted mean of these three measurements, t1/2 = (1.04 ± 0.05) × 105 yr, as the most probable half-life of 41Ca. We also discuss the situation of the radioisotopes, 32Si, 44Ti, 79Se and 126Sn, whose half-lives, though still uncertain, are potentially interesting for future AMS studies and other applications.


Sign in / Sign up

Export Citation Format

Share Document