scholarly journals Benchmarking geant4 nuclear models for hadron therapy with 95 MeV/nucleon carbon ions

2014 ◽  
Vol 89 (5) ◽  
Author(s):  
J. Dudouet ◽  
D. Cussol ◽  
D. Durand ◽  
M. Labalme
Keyword(s):  
Carbon Ions ◽  
Hadron Therapy ◽  
Nuclear Models

scholarly journals Synchrotron FTIR Microspectroscopy Investigations on Biochemical Changes Occurring in Human Cells Exposed to Proton Beams

2021 ◽  
Vol 12 (1) ◽  
pp. 336
Author(s):  
Ines Delfino ◽  
Valerio Ricciardi ◽  
Maria Lepore
Keyword(s):  
Radiation Effects ◽  
Human Cells ◽  
Biochemical Changes ◽  
Carbon Ions ◽  
Cancer Treatments ◽  
Heavy Particles ◽  
Proton Beams ◽  
Hadron Therapy ◽  
Particle Irradiation ◽  
Cell Components

Fourier transform infrared microspectroscopy using a synchrotron radiation source (SR-μFTIR) has great potential in the study of the ionizing radiation effects of human cells by analyzing the biochemical changes occurring in cell components. SR-μFTIR spectroscopy has been usefully employed in recent years in some seminal work devoted to shedding light on processes occurring in cells treated by hadron therapy, that is, radiotherapy with charged heavy particles (mainly protons and carbon ions), which is gaining popularity as a cancer treatment modality. These studies are particularly useful for increasing the effectiveness of radiotherapy cancer treatments with charged particles that can offer significant progress in the treatment of deep-seated and/or radioresistant tumors. In this paper, we present a concise revision of these studies together with the basic principles of μFTIR spectroscopy and a brief presentation of the main characteristics of infrared SR sources. From the analysis of the literature regarding the SR-μFTIR spectroscopy investigation on human cells exposed to proton beams, it is clearly shown that changes in DNA, protein, and lipid cell components are evident. In addition, this review points out that the potential offered by SR-μFTIR in investigating the effects induced by charged particle irradiation have not been completely explored. This is a crucial point for the continued improvement of hadron therapy strategies.

scholarly journals Benchmarking of FLUKA production cross sections of positron emission tomography isotopes for in-vivo range verification in hadron therapy

2020 ◽  
Vol 239 ◽  
pp. 24001
Author(s):  
Giulia Aricò ◽  
Giuseppe Battistoni ◽  
Francesco Cerutti ◽  
Felix Horst ◽  
Andrea Mairani ◽  
...  
Keyword(s):  
Cross Sections ◽  
Production Cross ◽  
Carbon Ions ◽  
Carbon Ion ◽  
Hadron Therapy ◽  
Positron Emission ◽  
Positron Emitters ◽  
Range Verification

Protons and carbon ions have been extensively used for radiotherapy treatments, and in comparison to conventional radiotherapy, they allow a more conformal dose to the target tumor, especially in case of deep-seated tumors. However, the accuracy of hadron therapy treatments is affected by uncertainties in the particle range calculations. Several techniques are under development for in-vivo range verification, one of which consists on measuring the activity distributions of positron emitters, such as 10C, 11C and 15O, which are produced in the patient body during proton and carbon ion treatments. A comparison between measured and expected positron emitter activity distributions can provide information on the quality of the delivered treatment and accuracy of the particle range calculations. In this work the FLUKA production cross sections for 10C, 11C and 15O originated from proton and carbon ion beams in carbon and oxygen targets were compared with experimental data, at low and therapeutic energies.

XUV Absorption Spectra of Carbon Ions

1988 ◽  
Vol 102 ◽  
pp. 71-73
Author(s):  
E. Jannitti ◽  
P. Nicolosi ◽  
G. Tondello
Keyword(s):  
Absorption Spectra ◽  
Cross Section ◽  
Theoretical Calculations ◽  
Photoionization Cross Section ◽  
Carbon Ions

AbstractThe photoabsorption spectra of the carbon ions have been obtained by using two laser-produced plasmas. The photoionization cross-section of the CV has been absolutely measured and the value at threshold, σ=(4.7±0.5) × 10−19cm2, as well as its behaviour at higher energies agrees quite well with the theoretical calculations.

Laser ion acceleration for hadron therapy

2014 ◽  
Vol 184 (12) ◽  
pp. 1265-1298 ◽  
Author(s):  
Sergei V. Bulanov ◽  
Jan J. Wilkens ◽  
Timur Zh. Esirkepov ◽  
Georg Korn ◽  
G. Kraft ◽  
...  
Keyword(s):  
Ion Acceleration ◽  
Hadron Therapy

scholarly journals Focused Ion Microbeam Irradiation Induces Clustering of DNA Double-Strand Breaks in Heterochromatin Visualized by Nanoscale-Resolution Electron Microscopy

2021 ◽  
Vol 22 (14) ◽  
pp. 7638
Author(s):  
Yvonne Lorat ◽  
Judith Reindl ◽  
Anna Isermann ◽  
Christian Rübe ◽  
Anna A. Friedl ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Dna Damage ◽  
Spatial Clustering ◽  
Dna Lesions ◽  
Double Strand Breaks ◽  
Stimulated Emission ◽  
Nuclear Chromatin ◽  
Carbon Ions ◽  
Dna Double Strand Breaks ◽  
Strand Breaks

Background: Charged-particle radiotherapy is an emerging treatment modality for radioresistant tumors. The enhanced effectiveness of high-energy particles (such as heavy ions) has been related to the spatial clustering of DNA lesions due to highly localized energy deposition. Here, DNA damage patterns induced by single and multiple carbon ions were analyzed in the nuclear chromatin environment by different high-resolution microscopy approaches. Material and Methods: Using the heavy-ion microbeam SNAKE, fibroblast monolayers were irradiated with defined numbers of carbon ions (1/10/100 ions per pulse, ipp) focused to micrometer-sized stripes or spots. Radiation-induced lesions were visualized as DNA damage foci (γH2AX, 53BP1) by conventional fluorescence and stimulated emission depletion (STED) microscopy. At micro- and nanoscale level, DNA double-strand breaks (DSBs) were visualized within their chromatin context by labeling the Ku heterodimer. Single and clustered pKu70-labeled DSBs were quantified in euchromatic and heterochromatic regions at 0.1 h, 5 h and 24 h post-IR by transmission electron microscopy (TEM). Results: Increasing numbers of carbon ions per beam spot enhanced spatial clustering of DNA lesions and increased damage complexity with two or more DSBs in close proximity. This effect was detectable in euchromatin, but was much more pronounced in heterochromatin. Analyzing the dynamics of damage processing, our findings indicate that euchromatic DSBs were processed efficiently and repaired in a timely manner. In heterochromatin, by contrast, the number of clustered DSBs continuously increased further over the first hours following IR exposure, indicating the challenging task for the cell to process highly clustered DSBs appropriately. Conclusion: Increasing numbers of carbon ions applied to sub-nuclear chromatin regions enhanced the spatial clustering of DSBs and increased damage complexity, this being more pronounced in heterochromatic regions. Inefficient processing of clustered DSBs may explain the enhanced therapeutic efficacy of particle-based radiotherapy in cancer treatment.

Design of the First HTS Single-Coil Demonstrator of GaToroid Toroidal Gantry for Hadron Therapy

2021 ◽  
pp. 1-1
Author(s):  
Enrico Felcini ◽  
Jerome Harray ◽  
Tuukka Lehtinen ◽  
Diego Perini ◽  
Juan Carlos Perez ◽  
...  
Keyword(s):  
Hadron Therapy ◽  
Single Coil
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