scholarly journals Determination of theνeand totalB8solar neutrino fluxes using the Sudbury Neutrino Observatory Phase I data set

2007 ◽  
Vol 75 (4) ◽  
Author(s):  
B. Aharmim ◽  
Q. R. Ahmad ◽  
S. N. Ahmed ◽  
R. C. Allen ◽  
T. C. Andersen ◽  
...  
2013 ◽  
Vol 87 (1) ◽  
Author(s):  
B. Aharmim ◽  
S. N. Ahmed ◽  
J. F. Amsbaugh ◽  
J. M. Anaya ◽  
A. E. Anthony ◽  
...  

2021 ◽  
Author(s):  
Anna Mieszkowska ◽  
Koleta Hemine ◽  
Anna Skwierawska ◽  
Ewa Augustin ◽  
Zofia Mazerska

AbstractThe present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase II, including UGT, often creates problems in correct selection of valuable compounds. Moreover, microsomes data set is richer in the contest and provides medical scientist to determine also the susceptibility of drugs to undergo phase I and then phase II. In the present work, we have shown that IS-noh was metabolized in vitro by phase I enzymes to the oxidation product, which was next transformed with UGTs to glucuronide. The results showed also that the previously known oxidation product of opipramol was changed to previously no reported glucuronidation product by UDP-glucuronosyltransferases. In addition, unlike IS-noh, opipramol did not prove to be the substrate for UGTs. Therefore, tricyclic antidepressants depending on the structure can trigger a different response after contact with UGT enzymes. Some will metabolize directly with UGTs, others only after activation by phase I enzymes.


Animals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 50
Author(s):  
Jennifer Salau ◽  
Jan Henning Haas ◽  
Wolfgang Junge ◽  
Georg Thaller

Machine learning methods have become increasingly important in animal science, and the success of an automated application using machine learning often depends on the right choice of method for the respective problem and data set. The recognition of objects in 3D data is still a widely studied topic and especially challenging when it comes to the partition of objects into predefined segments. In this study, two machine learning approaches were utilized for the recognition of body parts of dairy cows from 3D point clouds, i.e., sets of data points in space. The low cost off-the-shelf depth sensor Microsoft Kinect V1 has been used in various studies related to dairy cows. The 3D data were gathered from a multi-Kinect recording unit which was designed to record Holstein Friesian cows from both sides in free walking from three different camera positions. For the determination of the body parts head, rump, back, legs and udder, five properties of the pixels in the depth maps (row index, column index, depth value, variance, mean curvature) were used as features in the training data set. For each camera positions, a k nearest neighbour classifier and a neural network were trained and compared afterwards. Both methods showed small Hamming losses (between 0.007 and 0.027 for k nearest neighbour (kNN) classification and between 0.045 and 0.079 for neural networks) and could be considered successful regarding the classification of pixel to body parts. However, the kNN classifier was superior, reaching overall accuracies 0.888 to 0.976 varying with the camera position. Precision and recall values associated with individual body parts ranged from 0.84 to 1 and from 0.83 to 1, respectively. Once trained, kNN classification is at runtime prone to higher costs in terms of computational time and memory compared to the neural networks. The cost vs. accuracy ratio for each methodology needs to be taken into account in the decision of which method should be implemented in the application.


2006 ◽  
Vol 06 (04) ◽  
pp. 373-384
Author(s):  
ERIC BERTHONNAUD ◽  
JOANNÈS DIMNET

Joint centers are obtained from data treatment of a set of markers placed on the skin of moving limb segments. Finite helical axis (FHA) parameters are calculated between time step increments. Artifacts associated with nonrigid body movements of markers entail ill-determination of FHA parameters. Mean centers of rotation may be calculated over the whole movement, when human articulations are likened to spherical joints. They are obtained using numerical technique, defining point with minimal amplitude, during joint movement. A new technique is presented. Hip, knee, and ankle mean centers of rotation are calculated. Their locations depend on the application of two constraints. The joint center must be located next to the estimated geometric joint center. The geometric joint center may migrate inside a cube of possible location. This cube of error is located with respect to the marker coordinate systems of the two limb segments adjacent to the joint. Its position depends on the joint and the patient height, and is obtained from a stereoradiographic study with specimen. The mean position of joint center and corresponding dispersion are obtained through a minimization procedure. The location of mean joint center is compared with the position of FHA calculated between different sequential steps: time sequential step, and rotation sequential step where a minimal rotation amplitude is imposed between two joint positions. Sticks are drawn connecting adjacent mean centers. The animation of stick diagrams allows clinical users to estimate the displacements of long bones (femur and tibia) from the whole data set.


1989 ◽  
Vol 79 (2) ◽  
pp. 493-499
Author(s):  
Stuart A. Sipkin

Abstract The teleseismic long-period waveforms recorded by the Global Digital Seismograph Network from the two largest Superstition Hills earthquakes are inverted using an algorithm based on optimal filter theory. These solutions differ slightly from those published in the Preliminary Determination of Epicenters Monthly Listing because a somewhat different, improved data set was used in the inversions and a time-dependent moment-tensor algorithm was used to investigate the complexity of the main shock. The foreshock (origin time 01:54:14.5, mb 5.7, Ms 6.2) had a scalar moment of 2.3 × 1025 dyne-cm, a depth of 8 km, and a mechanism of strike 217°, dip 79°, rake 4°. The main shock (origin time 13:15:56.4, mb 6.0, Ms 6.6) was a complex event, consisting of at least two subevents, with a combined scalar moment of 1.0 × 1026 dyne-cm, a depth of 10 km, and a mechanism of strike 303°, dip 89°, rake −180°.


1996 ◽  
Vol 86 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Cheng-Horng Lin ◽  
S. W. Roecker

Abstract Seismograms of earthquakes and explosions recorded at local, regional, and teleseismic distances by a small-aperture, dense seismic array located on Pinyon Flat, in southern California, reveal large (±15°) backazimuth anomalies. We investigate the causes and implications of these anomalies by first comparing the effectiveness of estimating backazimuth with an array using three different techniques: the broadband frequency-wavenumber (BBFK) technique, the polarization technique, and the beamforming technique. While each technique provided nearly the same direction as a most likely estimate, the beamforming estimate was associated with the smallest uncertainties. Backazimuth anomalies were then calculated for the entire data set by comparing the results from beamforming with backazimuths derived from earthquake locations reported by the Anza and Caltech seismic networks and the Preliminary Determination of Epicenters (PDE) Bulletin. These backazimuth anomalies have a simple sinelike dependence on azimuth, with the largest anomalies observed from the southeast and northwest directions. Such a trend may be explained as the effect of one or more interfaces dipping to the northeast beneath the array. A best-fit model of a single interface has a dip and strike of 20° and 315°, respectively, and a velocity contrast of 0.82 km/sec. Application of corrections computed from this simple model to ray directions significantly improves locations at all distances and directions, suggesting that this is an upper crustal feature. We confirm that knowledge of local structure can be very important for earthquake location by an array but also show that corrections computed from simple models may not only be adequate but superior to those determined by raytracing through smoothed laterally varying models.


Author(s):  
Peter Grant ◽  
Jeffrey S. Freeman ◽  
Rob Vail ◽  
Frank Huck

Abstract A multi-phased evaluation of the Iowa Driving Simulator as a virtual proving ground for construction equipment simulation is presented. In Phase I the Iowa Driving Simulator was evaluated in an “open-loop” mode to assess its capability to simulate a typical maneuver common to wheel loader operation, and its viability as a test platform for human subject evaluation of those maneuvers. A typical wheel loader truck loading cycle involves numerous directional shifts. Cycle productivity is increased if these shifts are executed at full engine throttle. Jerk and acceleration levels associated with full throttle shifts, however, can cause both operator discomfort and spillage of loaded material. Electronically controlled transmissions have the potential to both minimize directional shift times and material loss while optimizing operator comfort. This optimization will require an understanding of the factors which affect operator comfort during shifts. A study was therefore devised to determine those aspects of the motion generated by a directional shift which affect operator comfort. The Iowa Driving Simulator motion system was used to present operators with a series of acceleration time histories which are representative of various shift strategies. The operators rated the relative comfort of each strategy during paired comparison tests. Limitations of the simulator motion system prevented definitive results from being drawn; however, results did confirm shift comfort criteria previously established by the machine manufacturer. Success of the Phase I effort was sufficient to warrant a more in-depth study. In Phase II a complete VPG environment for wheel loader operation on the IDS was developed and qualitatively evaluated. This VPG environment included a visual model of a mine pit, developed for Caterpillar, Inc. by engineers at its National Center for Supercomputing Applications office, combined with the immersive motion capability of the Iowa Driving Simulator. A real-time dynamics model of a generic wheel loader along with a menu driven interface to the data set used to simulate a particular wheel loader were developed at Center for Computer Aided Design. This combination of programs allows changes to the design of a loader to be rapidly evaluated within a virtual proving ground environment or off-line at an engineering workstation. The machine model was then combined with an implement/soil interaction model, also developed at Caterpillar’s National Center for Supercomputing Applications office. The resulting machine model can be evaluated either off-line at a workstation or driven in response to operator input within the Iowa Driving Simulator virtual proving ground environment. A comparison of the offline model’s predictions of machine response to swept-sinewave steering input is shown to compare favorably with measured performance of the actual machine.


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