scholarly journals Target fragment energies and momenta in the reaction of 4.8 GeVC12and 5.0 GeVNe20withU238

1981 ◽  
Vol 24 (2) ◽  
pp. 464-475 ◽  
Author(s):  
W. Loveland ◽  
Cheng Luo ◽  
P. L. McGaughey ◽  
D. J. Morrissey ◽  
G. T. Seaborg
Keyword(s):  
1985 ◽  
Vol 432 (2) ◽  
pp. 525-554 ◽  
Author(s):  
R.H. Kraus ◽  
W. Loveland ◽  
K. Aleklett ◽  
P.L. McGaughey ◽  
T.T. Sugihara ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Lei Wang ◽  
Feng Ding ◽  
Shaojie Shi ◽  
Xingxing Wang ◽  
Sijia Zhang ◽  
...  

The abnormal environment of type 2 diabetes mellitus (T2DM) leads to a substantial decrease in osteogenic function of stem cells. However, the gene sequence does not vary before and after disease for the patient. This phenomenon may be related to changes in osteogenesis-related gene expression caused by DNA methylation. In this study, we established T2DM models to extract adipose-derived stem cells (ASCs) for different gene identifications through DNA methylation sequencing. Specific fragments of methylation changes in the target gene (Calca) were identified by IGV analysis. CGRP was applied to compare the effects on ASCs-T2DM morphology via phalloidin staining, proliferation through CCK-8 assay, and osteogenic differentiation with osteogenic staining, qPCR, and repair of calvarial defect. Furthermore, 5-azacytidine (5-az) was used to intervene ASCs-T2DM to verify the relationship between the methylation level of the target fragment and expression of Calca. We found that the DNA methylation level of target fragment of Calca in ASCs-T2DM was higher than that in ASCs-C. CGRP intervention showed that it did not change the morphology of ASCs-T2DM but could improve proliferation within a certain range. Meanwhile, it could significantly enhance the formation of ALP and calcium nodules in ASCs-T2DM, increase the expression of osteogenesis-related genes in vitro, and promote the healing of calvarial defects of T2DM rat in a concentration-dependent manner. 5-az intervention indicated that the reduction of the methylation level in Calca target fragment of ASCs-T2DM indeed escalated the gene expression, which may be related to DNMT1. Taken together, the environment of T2DM could upregulate the methylation level in the promoter region of Calca and then decrease the Calca expression. The coding product of Calca revealed a promoting role for osteogenic differentiation of ASCs-T2DM. This result provides an implication for us to understand the mechanism of the decreased osteogenic ability of ASCs-T2DM and improve its osteogenic capacity.


1983 ◽  
Vol 28 (6) ◽  
pp. 2519-2520 ◽  
Author(s):  
Y. Morita ◽  
W. Loveland ◽  
G. T. Seaborg

1986 ◽  
Vol 447 ◽  
pp. 95-100 ◽  
Author(s):  
R. Coniglione ◽  
G. Lanzano ◽  
A. Pagano ◽  
J. Barrette ◽  
B. Berthier ◽  
...  
Keyword(s):  

1990 ◽  
Vol 42 (4) ◽  
pp. 1753-1756 ◽  
Author(s):  
W. Loveland ◽  
M. Hellström ◽  
L. Sihver ◽  
K. Aleklett

2011 ◽  
Vol 50-51 ◽  
pp. 594-598
Author(s):  
Ai Ming Wang ◽  
Ji Peng Wang ◽  
Yan Qiang Ge ◽  
Guo Ying Liu ◽  
Wen Ying Ge

An dynamic suspected target fragment database based on three elements (bone block, fragment and feature) is designed to store pending oracle bone fragments to be rejoined. Oracle bone fragments images are preprocessed on the basis of texture and target/background difference, and then extracted the contour feature, regional feature and trend feature based on actual demand for oracle bone rejoining. An intelligent oracle bone fragments rejoining system prototype is implemented.


1983 ◽  
Vol 61 (4) ◽  
pp. 701-707 ◽  
Author(s):  
B. V. Jacak ◽  
W. Loveland ◽  
D. J. Morrissey ◽  
P. L. McGaughey ◽  
G. T. Seaborg

The yields of target fragments from the interaction of 28 GeV protons with 238U have been measured, with special attention being given to those fragments with 160 ≤ A ≤ 200. From the measured fragment yields, isobarie production cross sections were calculated. Significant yields (σ(A) ~ 1–10 mb) of heavy target fragments (160 ≤ A ≤ 210) were found. These fragments are believed to be the non-fissioning survivors from the population of highly excited residual nuclei produced in the initial p-nucleus collision. A pedagogical calculation of the fission – particle emission competition shows how the initial highly excited heavy nuclei could evaporate ~20–50 particles while surviving fission competition.


1982 ◽  
Vol 26 (2) ◽  
pp. 511-518 ◽  
Author(s):  
Y. Morita ◽  
W. Loveland ◽  
P. L. McGaughey ◽  
G. T. Seaborg

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