Near-perfect conduction through a ferrocene-based molecular wire

2005 ◽  
Vol 71 (24) ◽  
Author(s):  
Stephanie A. Getty ◽  
Chaiwat Engtrakul ◽  
Lixin Wang ◽  
Rui Liu ◽  
San-Huang Ke ◽  
...  
2018 ◽  
Author(s):  
Steven Boggess ◽  
Shivaani Gandhi ◽  
Brian Siemons ◽  
Nathaniel Huebsch ◽  
Kevin Healy ◽  
...  

<div> <p>The ability to non-invasively monitor membrane potential dynamics in excitable cells like neurons and cardiomyocytes promises to revolutionize our understanding of the physiology and pathology of the brain and heart. Here, we report the design, synthesis, and application of a new class of fluorescent voltage indicator that makes use of a fluorene-based molecular wire as a voltage sensing domain to provide fast and sensitive measurements of membrane potential in both mammalian neurons and human-derived cardiomyocytes. We show that the best of the new probes, fluorene VoltageFluor 2 (fVF 2) readily reports on action potentials in mammalian neurons, detects perturbations to cardiac action potential waveform in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, shows a substantial decrease in phototoxicity compared to existing molecular wire-based indicators, and can monitor cardiac action potentials for extended periods of time. Together, our results demonstrate the generalizability of a molecular wire approach to voltage sensing and highlights the utility of fVF 2 for interrogating membrane potential dynamics.</p> </div>


Author(s):  
Marcus Edwards ◽  
Gaye White ◽  
Julea Butt ◽  
David J. Richardson ◽  
Thomas A. Clarke
Keyword(s):  

2019 ◽  
Vol 523 ◽  
pp. 1-6
Author(s):  
Yuxiu Wang ◽  
Cuicui Sun ◽  
Zhao-Di Yang ◽  
Hong Yu ◽  
Ping Pan ◽  
...  

2010 ◽  
Vol 21 (12) ◽  
pp. 125706 ◽  
Author(s):  
J Andzane ◽  
J Prikulis ◽  
D Dvorsek ◽  
D Mihailovic ◽  
D Erts
Keyword(s):  

2001 ◽  
Vol 79 (22) ◽  
pp. 3708-3710 ◽  
Author(s):  
Hiroshi Sakaguchi ◽  
Atsushi Hirai ◽  
Futoshi Iwata ◽  
Akira Sasaki ◽  
Toshihiko Nagamura ◽  
...  

2003 ◽  
Vol 19 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Shawn D. WETTIG ◽  
Chen-Zhong LI ◽  
Yi-Tao LONG ◽  
Heinz-Bernhard KRAATZ ◽  
Jeremy S. LEE

2009 ◽  
Vol 253 (3-4) ◽  
pp. 410-422 ◽  
Author(s):  
Li-Juan Fan ◽  
Yan Zhang ◽  
Clifford B. Murphy ◽  
Sarah E. Angell ◽  
Matthew F.L. Parker ◽  
...  

2017 ◽  
Vol 23 (69) ◽  
pp. 17497-17503 ◽  
Author(s):  
Zhenxin Zhang ◽  
Masahiro Sadakane ◽  
Michikazu Hara ◽  
Wataru Ueda

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