scholarly journals Wide-Field Dynamic Magnetic Microscopy Using Double-Double Quantum Driving of a Diamond Defect Ensemble

2021 ◽  
Vol 15 (5) ◽  
Author(s):  
Zeeshawn Kazi ◽  
Isaac M. Shelby ◽  
Hideyuki Watanabe ◽  
Kohei M. Itoh ◽  
Vaithiyalingam Shutthanandan ◽  
...  
Author(s):  
Jamie Soon ◽  
David Adams ◽  
Kishalay De ◽  
Antony Galla ◽  
Matthew Hankins ◽  
...  

2016 ◽  
Vol 55 (14) ◽  
pp. 3724 ◽  
Author(s):  
Hongying Wan ◽  
Yihang Zhou ◽  
Leslie Ying ◽  
Jing Meng ◽  
Liang Song ◽  
...  

2017 ◽  
Author(s):  
Elliott D. SoRelle ◽  
Derek Yecies ◽  
Orly Liba ◽  
F. Chris Bennett ◽  
Claus Moritz Graef ◽  
...  

AbstractLeukocyte populations, especially tumor-associated macrophages (TAMs), are capable of mediating both anti- and pro-tumor processes and play significant roles in the tumor microenvironment. Moreover, TAMs have been shown to exert substantial influence on the efficacy of various cancer immunotherapy treatment strategies. Laboratory investigation into the behavior of TAMs has been limited by a lack of methods capable of resolving the in vivo distribution and dynamics of this cell population across wide fields of view. Recent studies have employed magnetic resonance imaging and intravital microscopy in conjunction with nanoparticle labeling methods to detect TAMs and observe their responses to therapeutic agents. Here we describe a novel method to enable high-resolution, wide-field, longitudinal imaging of leukocytes based on contrast-enhanced Speckle-Modulating Optical Coherence Tomography (SM-OCT), which substantially reduces imaging noise. We were able to specifically label TAMs and activated microglia in vivo with large gold nanorod contrast agents (LGNRs) in an orthotopic murine glioblastoma model. After labeling, we demonstrated near real-time tracking of leukocyte migration and distribution within the tumors. The intrinsic resolution, imaging depth, and sensitivity of this method may facilitate detailed studies of the fundamental behaviors of TAMs in vivo, including their intratumoral distribution heterogeneity and the roles they play in modulating cancer proliferation. In future studies, the method described herein may also provide the necessary means to characterize TAM responses to immunotherapeutic regimens in a range of solid tumors.


2021 ◽  
Vol 15 (4) ◽  
Author(s):  
Connor A. Hart ◽  
Jennifer M. Schloss ◽  
Matthew J. Turner ◽  
Patrick J. Scheidegger ◽  
Erik Bauch ◽  
...  

Author(s):  
M. G. Lagally

It has been recognized since the earliest days of crystal growth that kinetic processes of all Kinds control the nature of the growth. As the technology of crystal growth has become ever more refined, with the advent of such atomistic processes as molecular beam epitaxy, chemical vapor deposition, sputter deposition, and plasma enhanced techniques for the creation of “crystals” as little as one or a few atomic layers thick, multilayer structures, and novel materials combinations, the need to understand the mechanisms controlling the growth process is becoming more critical. Unfortunately, available techniques have not lent themselves well to obtaining a truly microscopic picture of such processes. Because of its atomic resolution on the one hand, and the achievable wide field of view on the other (of the order of micrometers) scanning tunneling microscopy (STM) gives us this opportunity. In this talk, we briefly review the types of growth kinetics measurements that can be made using STM. The use of STM for studies of kinetics is one of the more recent applications of what is itself still a very young field.


1984 ◽  
Vol 45 (9) ◽  
pp. 1533-1541 ◽  
Author(s):  
R. Buisson ◽  
J.Q. Liu ◽  
J.C. Vial

1996 ◽  
Vol 166 (7) ◽  
pp. 801-803 ◽  
Author(s):  
L.V. Butov ◽  
A. Zrenner ◽  
M. Hagn ◽  
G. Abstreiter ◽  
G. Boehm ◽  
...  
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