Magnetic Resonance Determination of the Nuclear Moment of Tantalum-181 in KTaO3

1960 ◽  
Vol 120 (5) ◽  
pp. 1812-1815 ◽  
Author(s):  
Lawrence H. Bennett ◽  
J. I. Budnick
Keyword(s):  
Magnetic Resonance ◽  
Nuclear Moment

Magnetic Resonance Determination of the Nuclear Moment of Tantalum-181 in KTaO3

1961 ◽  
Vol 121 (6) ◽  
pp. 1864-1864
Author(s):  
Lawrence H. Bennett ◽  
J. I. Budnick
Keyword(s):  
Magnetic Resonance ◽  
Nuclear Moment

Zur Thermodynamik der hydrophoben Wechselwirkung; die Systeme Wasser + Glycin+ Harnstoff und Wasser + Alanin+ Harnstoff bei 25 °C / Thermodynamics of Hydrophobie Interaction in the Systems Water + Glycin + Urea and Water + Alanin + Urea at 25 °C

1973 ◽  
Vol 28 (9-10) ◽  
pp. 533-554 ◽  
Author(s):  
Lothar Rafflenbeul ◽  
Wa-Ming Pang ◽  
Hansjürgen Schönert ◽  
Klaus Haberle
Keyword(s):  
Amino Acid ◽  
Magnetic Resonance ◽  
Proton Magnetic Resonance ◽  
Pressure Measurements ◽  
Free Enthalpy ◽  
Heat Of Dilution ◽  
Ternary Solutions ◽  
Vapor Pressure Measurements ◽  
Calorimetric Determination

Abstract Isopiestic vapor pressure measurements and calorimetric determination of the heat of dilution have been performed and evaluated with respect to enthalpy, entropy and free enthalpy in the ternary solutions water+ glycin+ urea and water+ alanin + urea. The free enthalpy of transfer for the process: Amino acid from water to water+ urea, which can be derived from these measurements, does not agree with the value calculated from solubility measurements. The reason for this discrepancy and the values of entropy and enthalpy in terms of hydrophobic interaction are discussed. Supplementary measurements of the proton magnetic resonance in these solutions are included.

scholarly journals FSMP-06. IN VIVO MONITORING OF LDHA EXPRESSION IN GLIOBLASTOMA USING QUANTITATIVE EXCHANGED-LABEL TURNOVER 1H MRS TECHNIQUE

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. i17-i17
Author(s):  
Puneet Bagga ◽  
Laurie Rich ◽  
Mohammad Haris ◽  
Neil Wilson ◽  
Mitch Schnall ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Lactate Production ◽  
Deuterium Labeling ◽  
1H Mrs ◽  
In Vivo Monitoring ◽  
Lactate Turnover ◽  
Crucial Information ◽  
Specialized Hardware

Abstract Most cancers, including glioblastomas (GBMs), rely extensively on glycolysis to support growth, proliferation, and survival. A hallmark of this elevated glycolysis is overexpression of Lactate dehydrogenase-A (LDHA) protein leading to increased uptake of glucose and overproduction of lactate. Various clinical trials using LDHA as a target for diagnosis and treatment have yielded encouraging results. However, in vivo monitoring of LDHA expression has been challenging due to either requirement of administration of radioactive substrates or specialized hardware. In this presentation, we will demonstrate a new method-quantitative exchanged-label turnover MRS (QELT, or simply qMRS)-that increases the sensitivity of magnetic resonance-based metabolic mapping without the requirement for specialized hardware. qMRS relies on the administration of deuterated (2H-labeled) substrates to track the production of downstream metabolites. Since 2H is invisible on 1H MRS, replacement of 1H with 2H due to metabolic turnover leads to an overall reduction in 1H MRS signal for the corresponding metabolites. We applied our qMRS technique to monitor the rate of lactate production in a preclinical GBM model. Infusion of [6,6’-2H2]glucose led to downstream deuterium labeling of lactate, thereby resulting in a reduction in the 1.33 ppm lactate-CH3 peak on 1H MRS over time. The subtraction of post-administration 1H MR spectra from the pre-infusion spectra aided in the determination of the kinetics of the lactate turnover. We believe that the detection and quantification of lactate production kinetics may provide crucial information regarding tumor LDHA expression non-invasively in GBMs without requiring biopsies. Hence, qMRS is expected to open up new opportunities to probe LDHA expression differences in a variety of gliomas, including GBMs and astrocytomas. This method takes advantage of the universal availability and ease of implementation of 1H MRS on all clinical and preclinical magnetic resonance scanners.

Sign in / Sign up

Export Citation Format

Share Document