The mRNA Capping Apparatus as Drug Target and Guide to Eukaryotic Phylogeny

2001 ◽  
Vol 66 (0) ◽  
pp. 301-312 ◽  
Author(s):  
S. SHUMAN
Keyword(s):  
Drug Target ◽  
Mrna Capping ◽  
Eukaryotic Phylogeny

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

CGMP as a New Drug Target in Atrial Fibrillation

2020 ◽  
Author(s):  
N. I. Bork ◽  
N. Grammatika-Pavlidou ◽  
B. Reiter ◽  
E. Girdauskas ◽  
H. Reichenspurner ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Drug Target ◽  
New Drug

Cyclin dependent kinase 4 as promising drug target in adrenocortical carcinoma

2019 ◽  
Author(s):  
Raimunde Liang ◽  
Isabel Weigand ◽  
Silviu Sbiera ◽  
Stefan Kircher ◽  
Juliane Lippert ◽  
...  
Keyword(s):  
Adrenocortical Carcinoma ◽  
Drug Target ◽  
Cyclin Dependent Kinase
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