Induction of an Immune Response for Imaging Antigen-Presenting Cell/T-Cell Interactions

2011 ◽  
Vol 2011 (2) ◽  
pp. pdb.prot5566-pdb.prot5566
Author(s):  
M. P. Matheu ◽  
M. D. Cahalan ◽  
I. Parker
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Interactions ◽  
Antigen Presenting Cell ◽  
Antigen Presenting

Modeling T Cell-Antigen Presenting Cell Interactions

1993 ◽  
Vol 160 (3) ◽  
pp. 311-342 ◽  
Author(s):  
Michael A. Fishman ◽  
Alan S. Perelson
Keyword(s):  
T Cell ◽  
Cell Interactions ◽  
Antigen Presenting Cell ◽  
Cell Antigen ◽  
Antigen Presenting

scholarly journals Suppressive effects ofBifidobacterium longumon the production of Th2-attracting chemokines induced with T cell–antigen-presenting cell interactions

2009 ◽  
Vol 55 (3) ◽  
pp. 324-334 ◽  
Author(s):  
Noriyuki Iwabuchi ◽  
Noritoshi Takahashi ◽  
Jin-Zhong Xiao ◽  
Sumiko Yonezawa ◽  
Tomoko Yaeshima ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Interactions ◽  
Antigen Presenting Cell ◽  
Cell Antigen ◽  
Antigen Presenting

scholarly journals T cell–antigen-presenting cell interactions visualized in vivo in a model of antigen-specific inflammation

2008 ◽  
Vol 126 (3) ◽  
pp. 270-276 ◽  
Author(s):  
James T. Rosenbaum ◽  
Mischa B. Ronick ◽  
Xubo Song ◽  
Dongseok Choi ◽  
Stephen R. Planck
Keyword(s):  
T Cell ◽  
Cell Interactions ◽  
Antigen Presenting Cell ◽  
Cell Antigen ◽  
Antigen Presenting

scholarly journals Anatomical and Cellular Requirements for the Activation and Migration of Virus-Specific CD8+ T Cells to the Brain during Theiler's Virus Infection

2005 ◽  
Vol 79 (5) ◽  
pp. 3063-3070 ◽  
Author(s):  
Yanice V. Mendez-Fernandez ◽  
Michael J. Hansen ◽  
Moses Rodriguez ◽  
Larry R. Pease
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Lymphoid Organs ◽  
Antigen Presenting Cell ◽  
Antigen Presenting ◽  
The Brain

ABSTRACT Theiler's murine encephalomyelitis virus (TMEV) infection of the brain induces a virus-specific CD8+ T-cell response in genetically resistant mice. The peak of the immune response to the virus occurs 7 days after infection, with an immunodominant CD8+ T-cell response against a VP2-derived capsid peptide in the context of the Db molecule. The process of activation of antigen-specific T cells that migrate to the brain in the TMEV model has not been defined. The site of antigenic challenge in the TMEV model is directly into the brain parenchyma, a site that is considered immune privileged. We investigated the hypothesis that antiviral CD8+ T-cell responses are initiated in situ upon intracranial inoculation with TMEV. To determine whether a brain parenchymal antigen-presenting cell is responsible for the activation of virus-specific CD8+ T cells, we evaluated the CD8+ T-cell response to the VP2 peptide in bone marrow chimeras and mutant mice lacking peripheral lymphoid organs. The generation of the anti-TMEV CD8+ T-cell response in the brain requires priming by a bone marrow-derived antigen-presenting cell and the presence of peripheral lymphoid organs. Although our results show that activation of TMEV-specific CD8+ T cells occurs in the peripheral lymphoid compartment, they do not exclude the possibility that the immune response to TMEV is initiated by a brain-resident, bone marrow-derived, antigen-presenting cell.

scholarly journals Gene Related to Anergy in Lymphocytes (GRAIL) Expression in CD4+ T Cells Impairs Actin Cytoskeletal Organization during T Cell/Antigen-presenting Cell Interactions

2009 ◽  
Vol 284 (50) ◽  
pp. 34674-34681 ◽  
Author(s):  
Jill M. Schartner ◽  
William T. Simonson ◽  
Sarah A. Wernimont ◽  
Lauren M. Nettenstrom ◽  
Anna Huttenlocher ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Cell Interactions ◽  
Antigen Presenting Cell ◽  
Cytoskeletal Organization ◽  
Cell Antigen ◽  
Antigen Presenting
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