scholarly journals In Vivo Assessment of Neural Precursor Cell Cycle Kinetics in the Amphibian Retina

2019 ◽  
Vol 2019 (8) ◽  
pp. pdb.prot105536
Author(s):  
Morgane Locker ◽  
Muriel Perron
Keyword(s):  
Cell Cycle ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Cell Cycle Kinetics ◽  
In Vivo Assessment

scholarly journals The Rb-CDK4/6 Signaling Pathway Is Critical in Neural Precursor Cell Cycle Regulation

2000 ◽  
Vol 275 (43) ◽  
pp. 33593-33600 ◽  
Author(s):  
Kerry L. Ferguson ◽  
Steven M. Callaghan ◽  
Michael J. O'Hare ◽  
David S. Park ◽  
Ruth S. Slack
Keyword(s):  
Cell Cycle ◽  
Signaling Pathway ◽  
Cell Cycle Regulation ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Cycle Regulation

scholarly journals c- and N-myc Regulate Neural Precursor Cell Fate, Cell Cycle, and Metabolism to Direct Cerebellar Development

2010 ◽  
Vol 9 (4) ◽  
pp. 537-547 ◽  
Author(s):  
Alice Wey ◽  
Veronica Martinez Cerdeno ◽  
David Pleasure ◽  
Paul S. Knoepfler
Keyword(s):  
Cell Cycle ◽  
Cell Fate ◽  
Precursor Cell ◽  
Cerebellar Development ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
C And N

scholarly journals Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

2012 ◽  
Vol 441 (3) ◽  
pp. 927-939 ◽  
Author(s):  
Roland Hjerpe ◽  
Yann Thomas ◽  
Jesse Chen ◽  
Aleksandra Zemla ◽  
Siobhan Curran ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Proteasome Inhibitor ◽  
Proteasome Inhibition ◽  
Precursor Cell ◽  
Similar Process ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Small Proteins ◽  
Free Ubiquitin

Ubiquitin and UBL (ubiquitin-like) modifiers are small proteins that covalently modify other proteins to alter their properties or behaviours. Ubiquitin modification (ubiquitylation) targets many substrates, often leading to their proteasomal degradation. NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is the UBL most closely related to ubiquitin, and its best-studied role is the activation of CRLs (cullin-RING ubiquitin ligases) by its conjugation to a conserved C-terminal lysine residue on cullin proteins. The attachment of UBLs requires three UBL-specific enzymes, termed E1, E2 and E3, which are usually well insulated from parallel UBL pathways. In the present study, we report a new mode of NEDD8 conjugation (NEDDylation) whereby the UBL NEDD8 is linked to proteins by ubiquitin enzymes in vivo. We found that this atypical NEDDylation is independent of classical NEDD8 enzymes, conserved from yeast to mammals, and triggered by an increase in the NEDD8 to ubiquitin ratio. In cells, NEDD8 overexpression leads to this type of NEDDylation by increasing the concentration of NEDD8, whereas proteasome inhibition has the same effect by depleting free ubiquitin. We show that bortezomib, a proteasome inhibitor used in cancer therapy, triggers atypical NEDDylation in tissue culture, which suggests that a similar process may occur in patients receiving this treatment.

scholarly journals Electric Field Application In Vivo Regulates Neural Precursor Cell Behavior in the Adult Mammalian Forebrain

eNeuro ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. ENEURO.0273-20.2020 ◽  
Author(s):  
Elana Sefton ◽  
Stephanie N. Iwasa ◽  
Taylor Morrison ◽  
Hani E. Naguib ◽  
Milos R. Popovic ◽  
...  
Keyword(s):  
Electric Field ◽  
Field Application ◽  
Precursor Cell ◽  
Neural Precursor ◽  
Cell Behavior ◽  
Neural Precursor Cell

MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell–Delivered S-TRAIL in Human Gliomas

2007 ◽  
Vol 67 (19) ◽  
pp. 8994-9000 ◽  
Author(s):  
Maarten F. Corsten ◽  
Rafael Miranda ◽  
Randa Kasmieh ◽  
Anna M. Krichevsky ◽  
Ralph Weissleder ◽  
...  
Keyword(s):  
Precursor Cell ◽  
Neural Precursor ◽  
Neural Precursor Cell ◽  
Human Gliomas ◽  
Synergistic Cytotoxicity ◽  
Glioma Growth
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