Trans-4-hydroxy-3-methoxycinnamic acid (Ferulic acid)

2009 ◽  
Vol 2009 (10) ◽  
pp. pdb.caut2764-pdb.caut2764
Keyword(s):  
Ferulic Acid ◽  
Methoxycinnamic Acid

Effect of Transglutaminase and 4-hydroxy-3-methoxycinnamic Acid on the Properties of Film from Tilapia Skin Gelatin

2013 ◽  
Vol 781-784 ◽  
pp. 623-627 ◽  
Author(s):  
Zhi Hong Jiang ◽  
Shao Kui Zeng ◽  
Chao Hua Zhang ◽  
Wen Long Wu
Keyword(s):  
Hydrogen Bonds ◽  
Ferulic Acid ◽  
Gelatin Film ◽  
Wave Numbers ◽  
Methoxycinnamic Acid

The effect of modification with transglutaminase (TGase) and 4-hydroxy-3-methoxycinnamic acid (ferulic acid) on properties of tilapia skin gelatin film (TSGF) was researched. The results showed that the peroxide inhibition of modified TSGF increased from 14.7% to 62.0% and 52.1%, when concentrations of TGase and ferulic acid were 0.20 or 1.0 mg·mL-1. At the same time, the WVP coefficients were lower about 24.2% and 20.6%, respectively. The solubility of TSGF decreased with the increase in concentration of TGase and ferulic acid. As the formation of hydrogen bonds in the structure of the film, the amide A band was shifted towards higher wave numbers after modification.

scholarly journals Evaluation of Antioxidant Activity of Isoferulic Acid in vitro

2011 ◽  
Vol 6 (9) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Xiaozhen Wang ◽  
Xican Li ◽  
Dongfeng Chen
Keyword(s):  
Antioxidant Activity ◽  
Ferulic Acid ◽  
Aqueous Media ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Isoferulic Acid ◽  
Methoxycinnamic Acid ◽  
First Time ◽  
Positive Controls

Isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA), the isomer of ferulic acid (4-hydroxy-3-methoxycinnamic acid), is a rare phenolic acid occurring in Rhizoma Cimicifugae. Unlike ferulic acid, which has been well investigated, the antioxidant activity of IFA has not been measured. In this study, IFA was systematically evaluated for its in vitro antioxidant activity for the first time. IC50 values were calculated of 7.30±0.57, 4.58±0.17, 1.08±0.01, 8.84±0.43, 7.69±0.39, 1.57±0.2, 13.33±0.49 μg/mL, respectively, for lipid peroxidation, DPPH (1,1-diphenyl-2-picrylhydrazyl radical) and ABTS (3-ethylbenzthiazoline-6-sulfonic acid diammonium salt) radical scavenging, reducing power on Fe3+ and Cu2+ ions, and hydroxyl and superoxide anion radical scavenging. Comparison with the IC50 values with those of the positive controls, Trolox and butylated hydroxyanisole (BHA), it can be concluded that isoferulic acid is an effective natural antioxidant in both lipid and aqueous media.

Specific cotton leaf responses to wounding and treatment with cell-free extracts of Aspergillus flavus

1985 ◽  
Vol 63 (12) ◽  
pp. 2470-2472
Author(s):  
H. J. Zeringue Jr. ◽  
E. J. Conkerton ◽  
D. C. Chapital
Keyword(s):  
Ferulic Acid ◽  
Aspergillus Flavus ◽  
Leaf Tissue ◽  
Wound Response ◽  
Cotton Leaf ◽  
Fungal Extract ◽  
Cotton Plants ◽  
Methoxycinnamic Acid

When initial true leaves of 1-month postemergence Acala SJ-2 cotton plants were wounded by gentle abrasion, accumulations of ferulic acid (4-hydroxy-3-methoxycinnamic acid) were detected on the 3rd and 4th days after treatment. When similar wounds were immediately treated with cell-free extracts of Aspergillus flavus mycelia, elevated levels of scopoletin (6-methoxy-7-hydroxycoumarin) were produced, beginning 1 day after treatment and continuing for 7 days. Elevated levels of scopoletin were not detected in leaves that were only wounded, and enhanced quantities of ferulic acid were not observed in leaf tissue after wounding and exposure to the fungal extract. Accumulations of these compounds were not apparent in nonwounded controls. The results demonstrate a wound response distinct from the wound – fungal extract reaction.

scholarly journals Cytotoxicity of Ferulic Acid on T24 Cell Line Differentiated by Different Microenvironments

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Chiung-Chi Peng ◽  
Charng-Cherng Chyau ◽  
Hui-Er Wang ◽  
Chi-Huang Chang ◽  
Kuan-Chou Chen ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Cell Line ◽  
Biological Activities ◽  
Biological Significance ◽  
Cancer Cell Line ◽  
Bladder Cancer Cell Line ◽  
3D Cultures ◽  
Mass Transport Rate ◽  
Methoxycinnamic Acid ◽  
T24 Cell Line

Ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA) is a ubiquitous health beneficial phenolic acid. Although FA has shown a diversity of biological activities including anti-inflammatory, antihypercholesterolemic and anticancer bioactivities, studies revealing its adverse effects are accumulating. Recently, 3D-cultures are shown to exhibit uniquely biological behaviors different from that of 2D cultures. To understand whether the cytotoxicity of FA against the T24 cell line (a bladder cancer cell line) in 2D-culture could consistently retain similar bioactivity if cultured in the 3D-systems, we conducted this experiment with 2 mM FA. Much higher cytotoxicity was found for 3D- than 2D-culture, showing (2D vs. 3D): apoptotic rates, 64% and 76%; cell killing rates,3.00×105 cells mmol−1·h−1and2.63×106cells mmol−1·h−1, attaining a 8.77-fold. FA upregulated the activities at 72 h (2D vs. 3D in folds that of control): SOD, 1.73-folds (P<0.05) versus 3.18 folds (P<0.001); and catalase, 2.58 versus 1.33-folds. Comparing to the control (without FA), Bcl-2 was prominently downregulated while Bax, caspase-3 and cleaved caspase-9 were more upregulated in 3D-cultures (P<0.05). Conclusively, different microenvironments could elicit different biological significance which in part can be ascribed to different mass transport rate.

A Comprehensive Review on Therapeutic Applications of Ferulic Acid and its Novel Analogues: A Brief Literature

2021 ◽  
Vol 21 ◽  
Author(s):  
Ritchu Babbar ◽  
Sonia Dhiman ◽  
Rupanshi Grover ◽  
Arashmeet Kaur ◽  
Sandeep Arora
Keyword(s):  
Ferulic Acid ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Therapeutic Effects ◽  
Metal Chelation ◽  
Methoxycinnamic Acid ◽  
Anti Oxidant ◽  
Treatment Of Diabetes ◽  
Immense Potential ◽  
Inflammatory Action

The compound 4-hydroxy-3-methoxycinnamic acid, named as ferulic acid (FA), is a ubiquitous phenolic compound which is distributed extensively in the plant kingdom. Ferulic acid is a boon as it shows immense potential therapeutic effects which are useful in the treatment of diabetes, cancer, pulmonary and CVS diseases majorly due to its anti-oxidant and anti-inflammatory action. Ferulic acid exhibits other wide variety of biological activities such as, anticarcinogenic, antiallergic, antimicrobial, antiviral, hepatoprotective, metal chelation, activation of transcriptional factors, modulation of enzyme activity, gene expression as well as signal transduction. The structural characteristics of this active ingredient make it an optimal substrate to form or synthesize various derivates and its formulations. The present review addresses structure of ferulic acid, its pharmacodynamic parameters, applications and its various derivatives. In addition, the review also aims to cover the main aspects related to use of ferulic acid in the food and health industry and have listed various published patents on Ferulic acid.

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