(des-Gly10, D-Ala6)-LH-RH ethylamide acetate hydrate

2007 ◽  
Vol 2007 (10) ◽  
pp. pdb.caut2616
Keyword(s):  
2010 ◽  
Vol 01 (03) ◽  
pp. 139-140
Author(s):  
Luise Mansel
Keyword(s):  

Mehr als drei Viertel der Prostata-Karzinome sind Testosteron-sensitiv und wachsen primär hormonabhängig. Daher besteht die Standardtherapie in einer Behandlung mit LH-RH-Analoga (synthetische Gonadotropin-Releasing-Hormon-Analoga). Dabei kommt es durch pharmakologische Absenkung des Serumtestosteronspiegels auf Kastrationsniveau (<50 ng/dl) zur Verringerung der Tumorgröße oder zumWachstumsstillstand. Gegenüber der operativen Kastration hat die medikamentöse Hormonsenkung den Vorteil der Reversibilität.


1974 ◽  
Vol 75 (3) ◽  
pp. 428-434 ◽  
Author(s):  
P.-J. Czygan ◽  
M. Breckwoldt ◽  
F. Lehmann ◽  
R. Langefeld ◽  
G. Bettendorf

ABSTRACT The effect of synthetic LH-RH was studied in 100 patients with various types of ovarian insufficiency by following up the FSH- and LH-levels in plasma. LH-RH was administered in doses of 12.5, 25 and 100 μg as a rapid intravenous injection. The patients were classified according to the endocrine state of the pituitary as evidenced by the urinary gonadotrophin levels. A clear correlation between the functional state of the pituitary and its responsiveness to exogenous LH-RH was demonstrated. Most of the patients with undetectable low urinary gonadotrophin levels failed to respond. The majority of patients with gonadotrophin excretion in the normal range and those with elevated levels reacted with a dose dependent increase in circulating LH. The amount of liberated FSH however was related to the injected dose only in patients with high gonadotrophic excretion. The present study indicates that synthetic LH-RH provides a useful tool in the evaluation of the pitutiary function particularly in patients with low and with undetectable gonadotrophin excretion. The data presented in this paper also demonstrate that the functional state of the pituitary is clearly reflected by the urinary gonadotrophin levels.


1972 ◽  
Vol 68 (3_Suppl) ◽  
pp. S53
Author(s):  
F. Enzmann ◽  
K. Geisen ◽  
R. Geiger ◽  
W. König ◽  
H. Wissmann

1973 ◽  
Vol 71 (4_Suppl) ◽  
pp. S81
Author(s):  
M. Babej ◽  
J. Sandow ◽  
E. Kircher
Keyword(s):  

1975 ◽  
Vol 80 (1_Suppla) ◽  
pp. S20
Author(s):  
I. Gerhard ◽  
M. Röhrich ◽  
K. Klinga ◽  
B. Runnebaum
Keyword(s):  

1982 ◽  
Vol 92 (1) ◽  
pp. 141-146 ◽  
Author(s):  
R. L. MATTERI ◽  
G. P. MOBERG

During treatment with cortisol or ACTH, dairy heifers were given two doses of LH releasing hormone (LH-RH) spaced 1·5 h apart. Serum concentrations of cortisol and LH were monitored during each treatment. Treatment with both ACTH and cortisol raised plasma cortisol levels above the respective saline controls (P<0·001). Neither treatment affected basal LH concentrations. A slight depression in LH response was seen in the cortisol-treated animals after the first LH-RH injection, as shown by a statistically significant depression at three of the sample times. There was no significant difference between treated and control LH values after the second LH-RH administration. Treatment with ACTH resulted in significantly reduced LH values at all sample times after both injections of LH-RH.


1972 ◽  
Vol 3 (8) ◽  
pp. no-no
Author(s):  
PIERRE RIVAILLE ◽  
ARTHUR ROBINSON ◽  
MARTIN KAMEN ◽  
GERARD MILHAUD
Keyword(s):  

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