scholarly journals The diagnostic challenges and clinical course of a myeloid/lymphoid neoplasm with eosinophilia and ZBTB20-JAK2 gene fusion presenting as B-lymphoblastic leukemia

2020 ◽  
Vol 6 (2) ◽  
pp. a004937
Author(s):  
Winston Y. Lee ◽  
Ruthann B. Pfau ◽  
Sarah M. Choi ◽  
Jiong Yang ◽  
Hong Xiao ◽  
...  
Keyword(s):  
Gene Fusion ◽  
Clinical Course ◽  
Lymphoblastic Leukemia ◽  
Lymphoid Neoplasm

Follicular Lymphoma With a Burkitt Translocation—Predictor of an Aggressive Clinical Course: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (2) ◽  
pp. 210-213 ◽  
Author(s):  
Peter M. Voorhees ◽  
Kathryn A. Carder ◽  
Scott V. Smith ◽  
Lanier H. Ayscue ◽  
Kathleen W. Rao ◽  
...  
Keyword(s):  
Case Report ◽  
Follicular Lymphoma ◽  
Clinical Course ◽  
Lymphoblastic Leukemia ◽  
Initial Diagnosis ◽  
Indolent Lymphoma ◽  
Review Of The Literature ◽  
Cell Type ◽  
Aberrant Expression ◽  
Aggressive Clinical Course

Abstract Follicular lymphoma is an indolent lymphoma characterized by the (14;18) translocation, which leads to aberrant expression of Bcl-2. Translocations involving 8q24 are most commonly associated with Burkitt lymphoma and result in c-Myc overexpression. We report a case of follicular lymphoma of predominant small cleaved-cell type (grade 1) associated with both a t(14;18)(q32;q21) and a t(8;22)(q24;q11). The 8q24 translocation predicted an aggressive clinical course, as the lymphoma transformed into acute lymphoblastic leukemia within a year of initial diagnosis. Routine cytogenetic analysis is recommended at initial diagnosis of follicular lymphoma to better identify abnormalities that may predict prognosis and influence therapy.

scholarly journals A 10-Year Review of KMT2A Gene Fusion Partners Observed in Pediatric T-Lymphoblastic Leukemia/Lymphoma: The Mayo Clinic Experience

2018 ◽  
Vol 150 (suppl_1) ◽  
pp. S132-S132
Author(s):  
Jess Peterson ◽  
Linda Baughn ◽  
Kathryn Pearce ◽  
Reid Meyer ◽  
Patricia Greipp ◽  
...  
Keyword(s):  
Mayo Clinic ◽  
Gene Fusion ◽  
Lymphoblastic Leukemia ◽  
Clinic Experience

scholarly journals A New Subtype of Pre-B Acute Lymphoblastic Leukemia With t(5; 12)(q31q33; p12), Molecularly and Cytogenetically Distinct From t(5; 12) in Chronic Myelomonocytic Leukemia

Blood ◽  
1997 ◽  
Vol 89 (5) ◽  
pp. 1716-1722 ◽  
Author(s):  
Iwona Wlodarska ◽  
Anna Aventı́n ◽  
Júlia Inglés-Esteve ◽  
Daniela Falzetti ◽  
Arnold Criel ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Lymphoblastic Leukemia ◽  
Fluorescence In Situ Hybridization ◽  
Cell Lines ◽  
Chromosomal Abnormality ◽  
Gene Fusion ◽  
Lymphoblastic Leukemia ◽  
Chronic Myelomonocytic Leukemia ◽  
Myelomonocytic Leukemia

Abstract Translocation t(5; 12)(q33; p13), resulting in an ETV6/PDGFRB gene fusion, is a recurrent chromosomal abnormality associated with chronic myelomonocytic leukemia (CMML). An analogous translocation was also found in four cell lines with features of pre-B acute lymphoblastic leukemia (ALL). Using fluorescence in situ hybridization (FISH) we show here that in three of these cell lines identical complex rearrangements occurred. However, the regions involved on 5q and 12p are different from the breakpoints in CMML, and the translocation is accompanied by seemingly identical cryptic deletions of both 5q and 12p chromosome sequences in all analyzed pre-B ALL cell lines. The similar cytogenetic, FISH, and immunophenotyping findings in the three cell lines suggest that the t(5; 12)(q31q33; p12) defines a new entity of pre-B ALL.

Origin of a Central Nervous System Lymphoid Neoplasm in an Immunocompromised Host with Acute Lymphoblastic Leukemia

2002 ◽  
Vol 43 (9) ◽  
pp. 1881-1884
Author(s):  
Sharon P. Mayer ◽  
Somasundaram Jayabose ◽  
Oya Tugal ◽  
M. Fevzi Ozkaynak ◽  
Lynne Rosenblum-Vos ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Immunocompromised Host ◽  
Lymphoid Neoplasm

Physical Examination Can Predict the Risk of Infection in Patients with Febrile Neutropenia (FN)

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4365-4365
Author(s):  
Yotaro Tamai ◽  
Osamu Imataki ◽  
Kimihiro Kawakami ◽  
Terukazu Tanaka
Keyword(s):  
Febrile Neutropenia ◽  
Allergic Reaction ◽  
Clinical Course ◽  
Lymphoblastic Leukemia ◽  
Cancer Center ◽  
Skin Site ◽  
Infectious Focus ◽  
Infection Focus ◽  
Physical Examinations ◽  
Diagnosis Of Infection

Abstract Purpose In patients with febrile neutropenia (FN) who undergo chemotherapy, it is not common that the infection focus can be accurately diagnosed and a pathogen identified. In the initial phase of standard treatment for FN, the CDC guidelines specify administration of broad-spectrum antibiotics. However, these antibiotics should be de-escalated as soon as the pathogen and infection focus are identified. In order to evaluate an infection focus, we must first hear from the patients about their conditions and carry out careful physical examinations. Therefore, we studied the contribution of physical examinations to the identification of infection focus in patients of FN. Method We included patients who were admitted to the Division of Blood and Stem cell transplantation, Shizuoka Cancer Center Hospital, between February 2006 and July 2006, for treatment of hematological malignancies. We reviewed all events in patients whose axillary temperature reached 38.0 °C or higher during their chemotherapy courses. We studied the following items: the number of leukocytes and neutrophils at onset, duration of fever, concomitant catheter use, prophylactic antibiotics, regimen of empirical treatment, isolated pathogen, infection focus, mortality and the cause of death. We treated cases of continuous fever of 38.0 °C or higher as a single set of events. If the temperature fell below 38.0 °C and then returned to 38.0 °C or higher after a period of 48 hours or longer, we treated the second occurrence as a new case. The findings of physical examinations were classified into the following 4 categories: oral site, respiratory site, gastrointestinal site, and skin site (if any, including the portion of catheter insertion). The true infection focus was determined depending on the results of culture, otherwise, with reference to the patient’s clinical course. Criteria for decision of infection are below: a positive result of culture from an aseptic site, identification of a pathogen that can explain the patient’s clinical symptoms, or clinical course suggesting an infection supported by clinical examination or imaging. Non-infectious diseases were diagnosed by clinical information and categorized as tumor fever, allergic reaction or unknown fever. Results Overall, 85 FN episodes were observed. Patient characteristics included a median age of 56 years (range: 26–86) and a M:F ratio of 37:48. Of the 85 cases, there were 22 cases of acute myelogeneous leukemia, 16 acute lymphoblastic leukemia, 29 malignant lymphoma, 12 multiple myeloma and 6 others. The maximum degree of fever was 38.0–38.9°C in 68 cases (80%), 39.0–39.9°C in 13 cases (15%), and more than 40.0°C in 4 cases (5%). We detected at least one site of infectious focus in 63 cases (74.1%). The sites included 34 oral, 26 respiratory, 20 gastrointestinal and 11 skin. In some cases, infectious symptoms appeared in multiple sites; 2 sites in 15 cases, 3 in 2 cases and 4 in 5 cases. Of the 85 cases, the final diagnosis was infection in 17 cases (20%), tumor fever in 11 cases (13%), allergic reaction in 8 cases (9%) and unknown in 49 cases (58%). Among the 17 cases of infection, we were able to predict the infectious focus in 11. Multivariate analysis showed significant correlations between diagnosis of infection and three factors: first FN in treatment course (P=0.0021), bacterial prophylaxis (P=0.0054) and infectious findings of skin site (P=0.059, marginal). Conclusion Detailed physical examinations enable early and advance diagnosis of infection in cases of FN during chemotherapy.

p16 Inactivation Associated With Aggressive Clinical Course and Fatal Outcome in TEL/AML1-Positive Acute Lymphoblastic Leukemia

2005 ◽  
Vol 27 (12) ◽  
pp. 675-677 ◽  
Author(s):  
Stefanos I Papadhimitriou ◽  
S Polychronopoulou ◽  
A A Tsakiridou ◽  
G Androutsos ◽  
G S Paterakis ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Clinical Course ◽  
Lymphoblastic Leukemia ◽  
Fatal Outcome ◽  
Aggressive Clinical Course

scholarly journals Translocation ETS leukemia-acute myeloid leukemia 1 (TEL-AML1) gene fusion in childhood acute lymphoblastic leukemia

2009 ◽  
Vol 49 (5) ◽  
pp. 270
Author(s):  
Sri Mulatsih ◽  
Yeow Liang ◽  
Allen Yeoh ◽  
Sutaryo Sutaryo ◽  
Sunarto Sunarto
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Gene Fusion ◽  
Lymphoblastic Leukemia ◽  
Risk Groups ◽  
Molecular Characteristics ◽  
Rt Pcr ◽  
Cross Sectional ◽  
Childhood All ◽  
Diagnostic Quality ◽  
Aml1 Gene

Background Acute lymphoblastic leukemia (ALL) in childrenis a heterogeneous disease with different subtypes based on their cellular and molecular characteristics. This condition wouldinfluence the treatment outcome and subsequent risk for relapse. Accurate assignment of individual patients to risk groups is a critical issue for better outcome. TEL-AML1 gene fusion is themost frequent in childhood ALL.Objective The aim of this study was to investigate the incidenceofTEL-AML1 children with ALL in Sardjito Hospital.Methods This was a cross sectional study. In this preliminarystudy, we used nested reverse-transcriptase polymerase chainreaction (RT-PCR) to analyze the present of TEL-AML1 genefusion in bone marrow sample of childhood ALL patients.Results We analyzed 41 samples. Out of these, 30 (73%) wereamplified. Twenry three out of 30 ALL patients with good medicalrecord were analyzed for this gene fusion. Out of 30 patients, there were five patients (17%) with TEL-AML1-positive gene fusion and 25 (83%) were TEL-AML1-negative. Among five patients with TEL-AML1-positive gene fusion, four patients (80%) were one year to less than 10 year old. All of the patients (100%) were with leukocyte < 50x109/L.Conclusions TEL-AML1 gene fusion was found in 17 % ofsamples. This gene fusion was more frequent in standard risk group (based on age and leukocyte). These data must be clarified with more samples. RT-PCR must be apply in all center as one part of improving diagnostic quality, especially in managing leukemia patients.

scholarly journals CCDC88C‐FLT3 gene fusion in CD34‐positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia

2022 ◽  
Author(s):  
Yuya Kurihara ◽  
Hideaki Mizuno ◽  
Akira Honda ◽  
Arika Shimura ◽  
Yosei Fujioka ◽  
...  
Keyword(s):  
Gene Fusion ◽  
Lymphoid Neoplasm

scholarly journals Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Francesco Tarantini ◽  
Cosimo Cumbo ◽  
Luisa Anelli ◽  
Antonella Zagaria ◽  
Giorgina Specchia ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Clinical Course ◽  
Lymphoblastic Leukemia ◽  
Cell Precursor ◽  
Genomic Features ◽  
Dismal Prognosis ◽  
Definition Of ◽  
Review Current ◽  
Distinct Subtype

AbstractEarly T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.

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