scholarly journals Contributions of the medial temporal lobe to declarative memory retrieval: Manipulating the amount of contextual retrieval

2008 ◽  
Vol 15 (9) ◽  
pp. 611-617 ◽  
Author(s):  
I. Tendolkar ◽  
J. Arnold ◽  
K. M. Petersson ◽  
S. Weis ◽  
A. Brockhaus-Dumke ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Memory Retrieval ◽  
Medial Temporal Lobe ◽  
Declarative Memory ◽  
Contextual Retrieval

Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe

2003 ◽  
Vol 17 (6) ◽  
pp. 1296-1302 ◽  
Author(s):  
Dominique J.-F. De Quervain ◽  
Katharina Henke ◽  
Amanda Aerni ◽  
Valerie Treyer ◽  
James L. McGaugh ◽  
...  
Keyword(s):  
Blood Flow ◽  
Temporal Lobe ◽  
Memory Retrieval ◽  
Medial Temporal Lobe ◽  
Declarative Memory

Medial temporal lobe activation during autobiographical context memory retrieval of time and place and its dependency upon recency

Neurocase ◽  
2013 ◽  
Vol 21 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Silke Lux ◽  
Valeska N. Bindrich ◽  
Hans J. Markowitsch ◽  
Gereon R. Fink
Keyword(s):  
Temporal Lobe ◽  
Memory Retrieval ◽  
Medial Temporal Lobe ◽  
Context Memory

scholarly journals Differences in Mnemonic Processing by Neurons in the Human Hippocampus and Parahippocampal Regions

2006 ◽  
Vol 18 (10) ◽  
pp. 1654-1662 ◽  
Author(s):  
Indre V. Viskontas ◽  
Barbara J. Knowlton ◽  
Peter N. Steinmetz ◽  
Itzhak Fried
Keyword(s):  
Recognition Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Computational Models ◽  
Systems Approach ◽  
Declarative Memory ◽  
Neuronal Firing ◽  
Psychological Review ◽  
Firing Patterns ◽  
Human Hippocampus

Different structures within the medial-temporal lobe likely make distinct contributions to declarative memory. In particular, several current psychological and computational models of memory predict that the hippocampus and parahippocampal regions play different roles in the formation and retrieval of declarative memories [e.g., Norman, K. A., & O'Reilly, R. C. Modeling hippocampal and neocortical contributions to recognition memory: A complementary-learning systems approach. Psychological Review, 110, 611–646, 2003]. Here, we examined the neuronal firing patterns in these two regions during recognition memory. Recording directly from neurons in humans, we find that cells in both regions respond to novel stimuli with an increase in firing (excitation). However, already on the second presentation of a stimulus, neurons in these regions show very different firing patterns. In the parahippocampal region there is dramatic decrease in the number of cells responding to the stimuli, whereas in the hippocampus there is recruitment of a large subset of neurons showing inhibitory (decrease from baseline firing) responses. These results suggest that inhibition is a mechanism used by cells in the human hippocampus to support sparse coding in mnemonic processing. The findings also provide further evidence for the division of labor in the medial-temporal lobe with respect to declarative memory processes.

Medial temporal lobe stimulation may disrupt context-dependent memory retrieval

2015 ◽  
Vol 8 (2) ◽  
pp. 355 ◽  
Author(s):  
M.B. Merkow ◽  
J.F. Burke ◽  
A.R. Ramayya ◽  
A. Sharan ◽  
M.J. Kahana ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Memory Retrieval ◽  
Medial Temporal Lobe ◽  
Context Dependent

scholarly journals Age-related Alterations in Simple Declarative Memory and the Effect of Negative Stimulus Valence

2009 ◽  
Vol 21 (10) ◽  
pp. 1920-1933 ◽  
Author(s):  
Vishnu P. Murty ◽  
Fabio Sambataro ◽  
Saumitra Das ◽  
Hao-Yang Tan ◽  
Joseph H. Callicott ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Neural Activity ◽  
Medial Temporal Lobe ◽  
Declarative Memory ◽  
Recognition Performance ◽  
Negative Stimulus ◽  
Main Effect ◽  
Stimulus Valence ◽  
Effect Of Age ◽  
Encoding And Retrieval

Healthy aging has been shown to modulate the neural circuitry underlying simple declarative memory; however, the functional impact of negative stimulus valence on these changes has not been fully investigated. Using BOLD fMRI, we explored the effects of aging on behavioral performance, neural activity, and functional coupling during the encoding and retrieval of novel aversive and neutral scenes. Behaviorally, there was a main effect of valence with better recognition performance for aversive greater than neutral stimuli in both age groups. There was also a main effect of age with better recognition performance in younger participants compared to older participants. At the imaging level, there was a main effect of valence with increased activity in the medial-temporal lobe (amygdala and hippocampus) during both encoding and retrieval of aversive relative to neutral stimuli. There was also a main effect of age with older participants showing decreased engagement of medial-temporal lobe structures and increased engagement of prefrontal structures during both encoding and retrieval sessions. Interestingly, older participants presented with relatively decreased amygdalar–hippocampal coupling and increased amygdalar–prefrontal coupling when compared to younger participants. Furthermore, older participants showed increased activation in prefrontal cortices and decreased activation in the amygdala when contrasting the retrieval of aversive and neutral scenes. These results suggest that although normal aging is associated with a decline in declarative memory with alterations in the neural activity and connectivity of brain regions underlying simple declarative memory, memory for aversive stimuli is relatively better preserved than for neutral stimuli, possibly through greater compensatory prefrontal cortical activity.

scholarly journals The angular gyrus model of consciousness

2013 ◽  
Author(s):  
Graeme E Smith
Keyword(s):  
White Matter ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Declarative Memory ◽  
Angular Gyrus ◽  
Memory Model ◽  
White Matter Tracts ◽  
Parietal Lobes ◽  
Intersection Area ◽  
The Brain

The Angular Gyrus sits at the point where the Temporal and Parietal Lobes join. It is a point where integrative processes link together the Where and What pathways through the brain and link them to time. It is also the most likely location for at least two centers of consciousness. In this article the location is discussed and it's potential for a model of consciousness that replaces the Declarative Memory Model of Consciousness previously put forward. It's main benefit over the Declarative Memory Model of Consciousness is that it allows for the preservation of consciousness despite the loss of declarative memory in the cases of Medial Temporal Lobe injury/disease. However Connectome studies might support this model in that the TemporoParietal Fiber Intersection Area provides 7 different white matter tracts that intersect in this area.

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