scholarly journals Activation of the transcription factor NF- B by retrieval is required for long-term memory reconsolidation

2005 ◽  
Vol 12 (1) ◽  
pp. 23-29 ◽  
Author(s):  
E. Merlo
Keyword(s):  
Transcription Factor ◽  
Memory Reconsolidation ◽  
Long Term Memory ◽  
Term Memory

NF-κB transcription factor is required for inhibitory avoidance long-term memory in mice

2005 ◽  
Vol 21 (10) ◽  
pp. 2845-2852 ◽  
Author(s):  
Ramiro Freudenthal ◽  
Mariano M. Boccia ◽  
Gabriela B. Acosta ◽  
Mariano G. Blake ◽  
Emiliano Merlo ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Inhibitory Avoidance ◽  
Long Term Memory ◽  
Term Memory

scholarly journals Differential regulation of native and learned behavior by creb-1/crh-1 in Caenorhabditis elegans

2019 ◽  
Author(s):  
Yogesh Dahiya ◽  
Saloni Rose ◽  
Shruti Thapliyal ◽  
Shivam Bhardwaj ◽  
Maruthi Prasad ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Memory Formation ◽  
Long Term Memory ◽  
Null Mutant ◽  
Term Memory ◽  
Learned Behavior ◽  
C Elegans ◽  
Insight Into ◽  
Null Mutants

1.AbstractMemory formation is crucial for the survival of animals. Here, we study the effect of different crh-1 (C. elegans homolog of mammalian CREB1) mutations on the ability of C. elegans to form long-term memory (LTM). Null mutants in creb1/crh-1 are defective in LTM formation across phyla. We show that specific isoforms of CREB1/CRH-1, CRH-1c and CRH-1e, are primarily responsible for memory related functions of the transcription factor in C. elegans. Silencing of CRH-1e expressing neurons during training for LTM formation abolishes the long-term memory of the animal. Further, CRH-1e expression in RIM or AVE neurons is sufficient to rescue long-term memory defects of creb1/crh-1 null mutants. We show that apart from being LTM defective, creb1/crh-1 null mutant animals show defects in native chemotaxis behavior. We characterize the amino acids K247 and K266 as responsible for the LTM related functions of CRH-1 while being dispensable for it’s native chemotaxis behavior. These findings provide insight into the spatial and temporal workings of a crucial transcription factor and can be further exploited to find CREB1 targets involved in the process of memory formation.

scholarly journals PKA-activated ApAF–ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation

2006 ◽  
Vol 174 (6) ◽  
pp. 827-838 ◽  
Author(s):  
Jin-A Lee ◽  
Sue-Hyun Lee ◽  
Changhoon Lee ◽  
Deok-Jin Chang ◽  
Yong Lee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Transcription Factors ◽  
Long Term Memory ◽  
Term Memory ◽  
Downstream Effector ◽  
Necessary And Sufficient ◽  
Long Term Facilitation

Long-term memory requires transcriptional regulation by a combination of positive and negative transcription factors. Aplysia activating factor (ApAF) is known to be a positive transcription factor that forms heterodimers with ApC/EBP and ApCREB2. How these heterodimers are regulated and how they participate in the consolidation of long-term facilitation (LTF) has not, however, been characterized. We found that the functional activation of ApAF required phosphorylation of ApAF by PKA on Ser-266. In addition, ApAF lowered the threshold of LTF by forming a heterodimer with ApCREB2. Moreover, once activated by PKA, the ApAF–ApC/EBP heterodimer transactivates enhancer response element–containing genes and can induce LTF in the absence of CRE- and CREB-mediated gene expression. Collectively, these results suggest that PKA-activated ApAF–ApC/EBP heterodimer is a core downstream effector of ApCREB in the consolidation of LTF.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

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