scholarly journals ERK1/2 Activation Is Necessary for BDNF to Increase Dendritic Spine Density in Hippocampal CA1 Pyramidal Neurons

2004 ◽  
Vol 11 (2) ◽  
pp. 172-178 ◽  
Author(s):  
M. Alonso
Keyword(s):  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Spine Density ◽  
Ca1 Pyramidal Neurons ◽  
Dendritic Spine Density ◽  
Hippocampal Ca1

scholarly journals Hippocampal CA1 Pyramidal Neurons ofMecp2Mutant Mice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Christopher A. Chapleau ◽  
Elena Maria Boggio ◽  
Gaston Calfa ◽  
Alan K. Percy ◽  
Maurizio Giustetto ◽  
...  
Keyword(s):  
Dendritic Spines ◽  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Mutant Mice ◽  
Spine Density ◽  
Ca1 Pyramidal Neurons ◽  
Dendritic Spine Density ◽  
Presymptomatic Stage ◽  
Deficient Mice

Alterations in dendritic spines have been documented in numerous neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, an X chromosome-linked disorder associated with mutations inMECP2, is the leading cause of intellectual disabilities in women. Neurons inMecp2-deficient mice show lower dendritic spine density in several brain regions. To better understand the role of MeCP2 on excitatory spine synapses, we analyzed dendritic spines of CA1 pyramidal neurons in the hippocampus ofMecp2tm1.1Jaemale mutant mice by either confocal microscopy or electron microscopy (EM). At postnatal-day 7 (P7), well before the onset of RTT-like symptoms, CA1 pyramidal neurons from mutant mice showed lower dendritic spine density than those from wildtype littermates. On the other hand, at P15 or later showing characteristic RTT-like symptoms, dendritic spine density did not differ between mutant and wildtype neurons. Consistently, stereological analyses at the EM level revealed similar densities of asymmetric spine synapses in CA1stratum radiatumof symptomatic mutant and wildtype littermates. These results raise caution regarding the use of dendritic spine density in hippocampal neurons as a phenotypic endpoint for the evaluation of therapeutic interventions in symptomaticMecp2-deficient mice. However, they underscore the potential role of MeCP2 in the maintenance of excitatory spine synapses.

scholarly journals HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons

Hippocampus ◽  
2011 ◽  
Vol 22 (7) ◽  
pp. 1493-1500 ◽  
Author(s):  
Gaston Calfa ◽  
Christopher A. Chapleau ◽  
Susan Campbell ◽  
Takafumi Inoue ◽  
Sarah J. Morse ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Neurotransmitter Release ◽  
Pyramidal Neurons ◽  
Spine Density ◽  
Hdac Activity ◽  
Ca1 Pyramidal Neurons ◽  
Dendritic Spine Density

scholarly journals Five hours total sleep deprivation does not affect CA1 dendritic length or spine density

2021 ◽  
Author(s):  
Alvin T.S. Brodin ◽  
Sarolta Gabulya ◽  
Katrin Wellfelt ◽  
Tobias E. Karlsson
Keyword(s):  
Sleep Deprivation ◽  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Memory Function ◽  
Long Term Memory ◽  
Spine Density ◽  
Dendritic Length ◽  
Dendritic Spine Density ◽  
Hippocampal Ca1

AbstractSleep is essential for long term memory function. However the neuroanatomical consequences of sleep loss are disputed. Sleep deprivation has been reported to cause both decreases and increases of dendritic spine density. Here we use Thy1-GFP expressing transgenic mice to investigate the effects of acute sleep deprivation on the dendritic architecture of hippocampal CA1 pyramidal neurons. We found that five hours of sleep deprivation had no effect on either dendritic length or dendritic spine density. Our work suggests that no major neuroanatomical changes result from one episode of sleep deprivation.

scholarly journals Divergent Roles ofp75NTRand Trk Receptors in BDNF's Effects on Dendritic Spine Density and Morphology

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Christopher A. Chapleau ◽  
Lucas Pozzo-Miller
Keyword(s):  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Dendritic Morphology ◽  
Spine Density ◽  
Trk Receptors ◽  
Trk Receptor ◽  
Dendritic Spine Density ◽  
Trkb Receptors ◽  
Hippocampal Ca1 ◽  
Bdnf Signaling

Activation of TrkB receptors by brain-derived neurotrophic factor (BDNF) followed by MAPK/ERK signaling increases dendritic spine density and the proportion of mature spines in hippocampal CA1 pyramidal neurons. Considering the opposing actions ofp75NTRand Trk receptors in several BDNF actions on CNS neurons, we tested whether these receptors also have divergent actions on dendritic spine density and morphology. A function-blocking anti-p75NTRantibody (REX) did not affect spine density by itself but it prevented BDNF’s effect on spine density. Intriguingly, REX by itself increased the proportion of immature spines and prevented BDNF's effect on spine morphology. In contrast, the Trk receptor inhibitor k-252a increased spine density by itself, and prevented BDNF from further increasing spine density. However, most of the spines in k-252a-treated slices were of the immature type. These effects of k-252a on spine density and morphology required neuronal activity because they were prevented by TTX. These divergent BDNF actions on spine density and morphology are reminiscent of opposing functional signaling byp75NTRand Trk receptors and reveal an unexpected level of complexity in the consequences of BDNF signaling on dendritic morphology.

Dendritic Spine Density of Pyramidal Neurons in Field CA1 of the Hippocampus Decreases due to Chronic Tryptophan Restriction

1998 ◽  
Vol 1 (3) ◽  
pp. 237-242 ◽  
Author(s):  
M.I. Pérez-Vega ◽  
G. Barajas-López ◽  
A.R. del Angel-Meza ◽  
I. González-Burgos ◽  
A. Feria-Velasco
Keyword(s):  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Spine Density ◽  
Dendritic Spine Density ◽  
Field Ca1
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