scholarly journals Reorganization of learning-associated prefrontal synaptic plasticity between the recall of recent and remote fear extinction memory

2007 ◽  
Vol 14 (8) ◽  
pp. 520-524 ◽  
Author(s):  
S. Hugues ◽  
R. Garcia
Keyword(s):  
Synaptic Plasticity ◽  
Fear Extinction ◽  
Extinction Memory

scholarly journals Paradoxical Enhancement of Fear Extinction Memory and Synaptic Plasticity by Inhibition of the Histone Acetyltransferase p300

2011 ◽  
Vol 31 (20) ◽  
pp. 7486-7491 ◽  
Author(s):  
R. Marek ◽  
C. M. Coelho ◽  
R. K. P. Sullivan ◽  
D. Baker-Andresen ◽  
X. Li ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Histone Acetyltransferase ◽  
Fear Extinction ◽  
Extinction Memory ◽  
Acetyltransferase P300

scholarly journals IGF-1 facilitates extinction of conditioned fear

2020 ◽  
Author(s):  
José A. Noriega-Prieto ◽  
Laura E. Maglio ◽  
Irene B. Maroto ◽  
Jesús Martin-Cortecero ◽  
Antonio Muñoz-Callejas ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Animal Behavior ◽  
Pyramidal Neurons ◽  
Conditioned Fear ◽  
Fear Extinction ◽  
Neuronal Firing ◽  
Infralimbic Cortex ◽  
Regulatory Processes ◽  
Extinction Memory

SUMMARYInsulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, degenerative diseases, spatial learning, and anxiety-like behavioral processes. While IGF-1 regulates neuronal activity in many areas of the brain, its effect on synaptic plasticity and animal behavior dependent on the prefrontal cortex remain unexplored. Here, we show that IGF-1 induces a long-lasting depression of the medium and slow post-spike afterhyperpolarization (mAHP and sAHP), increasing the excitability of layer 5 pyramidal neurons of the infralimbic cortex. Besides, IGF-1 mediates a long-term depression of both inhibitory and excitatory synaptic transmission that results in a longterm potentiation of the postsynaptic potentials. We demonstrate that these synaptic and intrinsic regulatory processes mediated by IGF-1 favor the fear extinction memory. These results show novel functional consequences of IGF-1 signaling on animal behavior tasks dependent on the prefrontal cortex, revealing IGF-1 as a key element in the control of the fear extinction memory.Impact StatementIGF-1 modulates the neuronal firing and synaptic plasticity in infralimbic cortex, favoring the extinction memory

scholarly journals IGF-1 facilitates extinction of conditioned fear

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Laura E Maglio ◽  
José A Noriega-Prieto ◽  
Irene B Maroto ◽  
Jesús Martin-Cortecero ◽  
Antonio Muñoz-Callejas ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Synaptic Transmission ◽  
Pyramidal Neurons ◽  
Conditioned Fear ◽  
Long Term Potentiation ◽  
Fear Extinction ◽  
Neuronal Firing ◽  
Term Potentiation ◽  
Extinction Memory

Insulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, spatial learning and anxiety-like behavioral processes. While IGF-1 regulates neuronal firing and synaptic transmission in many areas of the central nervous system, its signaling and consequences on excitability, synaptic plasticity, and animal behavior dependent on the prefrontal cortex remain unexplored. Here, we show that IGF-1 induces a long-lasting depression of the medium and slow post-spike afterhyperpolarization (mAHP and sAHP), increasing the excitability of layer 5 pyramidal neurons of the rat infralimbic cortex. Besides, IGF-1 mediates a presynaptic long-term depression of both inhibitory and excitatory synaptic transmission in these neurons. The net effect of this IGF-1 mediated synaptic plasticity is a long-term potentiation of the postsynaptic potentials. Moreover, we demonstrate that IGF-1 favors the fear extinction memory. These results show novel functional consequences of IGF-1 signaling, revealing IGF-1 as a key element in the control of the fear extinction memory.

Partial and Total Sleep Deprivation Interferes With Neural Correlates of Consolidation of Fear Extinction Memory

2021 ◽  
Vol 89 (9) ◽  
pp. S176
Author(s):  
Jeehye Seo ◽  
Edward F. Pace-Schott ◽  
Mohammed R. Milad ◽  
Huijin Song ◽  
Anne Germain
Keyword(s):  
Sleep Deprivation ◽  
Neural Correlates ◽  
Fear Extinction ◽  
Total Sleep Deprivation ◽  
Extinction Memory

scholarly journals Fear Extinction as a Model for Synaptic Plasticity in Major Depressive Disorder

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115280 ◽  
Author(s):  
Marion Kuhn ◽  
Nora Höger ◽  
Bernd Feige ◽  
Jens Blechert ◽  
Claus Normann ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Synaptic Plasticity ◽  
Depressive Disorder ◽  
Fear Extinction ◽  
Major Depressive

scholarly journals The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

2011 ◽  
Vol 14 (9) ◽  
pp. 1115-1117 ◽  
Author(s):  
Quan Lin ◽  
Wei Wei ◽  
Carlos M Coelho ◽  
Xiang Li ◽  
Danay Baker-Andresen ◽  
...  
Keyword(s):  
Fear Extinction ◽  
Extinction Memory ◽  
The Brain
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