scholarly journals NMDA receptor-dependent processes in the medial prefrontal cortex are important for acquisition and the early stage of consolidation during trace, but not delay eyeblink conditioning

2005 ◽  
Vol 12 (6) ◽  
pp. 606-614 ◽  
Author(s):  
K. Takehara-Nishiuchi
Keyword(s):  
Prefrontal Cortex ◽  
Nmda Receptor ◽  
Medial Prefrontal Cortex ◽  
Early Stage ◽  
Eyeblink Conditioning ◽  
Dependent Processes

scholarly journals A Variable Oscillator Underlies the Measurement of Time Intervals in the Rostral Medial Prefrontal Cortex during Classical Eyeblink Conditioning in Rabbits

2015 ◽  
Vol 35 (44) ◽  
pp. 14809-14821 ◽  
Author(s):  
C. R. Caro-Martin ◽  
R. Leal-Campanario ◽  
R. Sanchez-Campusano ◽  
J. M. Delgado-Garcia ◽  
A. Gruart
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Eyeblink Conditioning ◽  
Time Intervals

MK-801, a NMDA receptor antagonist, increases phosphorylation of histone H3 in the rat medial prefrontal cortex

2013 ◽  
Vol 65 (5) ◽  
pp. 1112-1123 ◽  
Author(s):  
Marzena Maćkowiak ◽  
Rafał Guzik ◽  
Dorota Dudys ◽  
Ewelina Bator ◽  
Krzysztof Wędzony
Keyword(s):  
Prefrontal Cortex ◽  
Nmda Receptor ◽  
Receptor Antagonist ◽  
Medial Prefrontal Cortex ◽  
Histone H3 ◽  
Nmda Receptor Antagonist ◽  
Mk 801

Effects of lamotrigine on PCP-evoked elevations in monoamine levels in the medial prefrontal cortex of freely moving rats

2010 ◽  
Vol 25 (12) ◽  
pp. 1703-1711 ◽  
Author(s):  
Davide Quarta ◽  
Charles H Large
Keyword(s):  
Prefrontal Cortex ◽  
Locomotor Activity ◽  
Nmda Receptor ◽  
Medial Prefrontal Cortex ◽  
Significant Degree ◽  
Supporting Evidence ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Neurochemical Changes ◽  
Psychotomimetic Effects

Lamotrigine is suggested to have potential as an add-on treatment for patients with schizophrenia. Supporting evidence comes from the efficacy of the drug in models of psychotic-like behaviour induced by N-methyl-D-aspartate (NMDA) receptor antagonists, such as phencyclidine (PCP). These drugs enhance levels of the monoamines in the cortex, which may contribute to their psychotomimetic effects. The ability of lamotrigine to prevent these neurochemical changes has not been examined. We studied PCP-evoked overflow of noradrenaline, dopamine and serotonin in the medial prefrontal cortex of awake rats using microdialysis. Rats were administered lamotrigine or vehicle, followed by PCP. Locomotor activity was also recorded before and after drug treatment. Lamotrigine did not have an influence on basal levels of the monoamines, but significantly reduced PCP-evoked overflow of dopamine and serotonin; PCP-evoked overflow of noradrenaline was also reduced by lamotrigine, but not to a significant degree. In contrast, PCP-induced hyperactivity was unaffected by lamotrigine. It is concluded that lamotrigine can modify PCP-evoked monoamine overflow in the cortex, consistent with an ability to prevent the psychotomimetic effects of NMDA receptor antagonists in rodents and humans. The dissociation between monoamine overflow and locomotor activity suggests the involvement of different brain circuits; relevance to the treatment of schizophrenia is also discussed.

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