scholarly journals Dopamine and Mushroom Bodies in Drosophila: Experience-Dependent and -Independent Aspects of Sexual Behavior

1998 ◽  
Vol 5 (1) ◽  
pp. 157-165 ◽  
Author(s):  
Wendi S. Neckameyer
Keyword(s):  
Drosophila Melanogaster ◽  
Tyrosine Hydroxylase ◽  
Sexual Receptivity ◽  
Mushroom Bodies ◽  
Normal Female ◽  
Memory Retention ◽  
Adult Males ◽  
Mature Adult ◽  
Dopaminergic Modulation ◽  
Female Sexual Receptivity

Depletion of dopamine in Drosophila melanogaster adult males, accomplished through systemic introduction of the tyrosine hydroxylase inhibitor 3-iodo-tyrosine, severely impaired the ability of these flies to modify their courtship responses to immature males. Mature males, when first exposed to immature males, will perform courtship rituals; the intensity and duration of this behavior rapidly diminshes with time. Dopamine is also required for normal female sexual receptivity; dopamine-depleted females show increased latency to copulation. One kilobase of 5′ upstream information from theDrosophila tyrosine hydroxylase (DTH) gene, when fused to theEscherichia coli β-galactosidase reporter and transduced into the genome of Drosophila melanogaster, is capable of directing expression of the reporter gene in the mushroom bodies, which are believed to mediate learning acquisition and memory retention in flies. Ablation of mushroom bodies by treatment of newly hatched larva with hydroxyurea resulted in the inability of treated mature adult males to cease courtship when placed with untreated immature males. However, functional mushroom bodies were not required for the dopaminergic modulation of an innate behavior, female sexual receptivity. These data suggest that dopamine acts as a signaling molecule within the mushroom bodies to mediate a simple form of learning.

Elements of the fruitless locus regulate development of the muscle of Lawrence, a male-specific structure in the abdomen of Drosophila melanogaster adults

Development ◽  
1991 ◽  
Vol 113 (3) ◽  
pp. 879-890 ◽  
Author(s):  
D.A. Gailey ◽  
B.J. Taylor ◽  
J.C. Hall
Keyword(s):  
Drosophila Melanogaster ◽  
Abdominal Segment ◽  
Causative Factor ◽  
Normal Female ◽  
Adult Males ◽  
Double Deletion ◽  
Imprecise Excision ◽  
Specific Muscle ◽  
Male Specific ◽  
And Inversion

A genetically defined element of the fruitless (fru) locus in Drosophila melanogaster regulates the development of a male-specific muscle spanning the fifth abdominal segment in adult males, the ‘muscle of Lawrence’ (MOL). The region is defined by two cytological deletions, each with a breakpoint that co-maps with previously described mutant courtship phenotypes at cytogenetic interval 91B on the third chromosome. Flies that carry both of these deletions are viable, and males express abnormalities of courtship similar to those caused by the fru inversion breakpoint at 91B. In addition, these double-deletion males show the complete absence of the MOL, suggesting that they have little or no gene expression of a postulated MOL determinant; the musculature in the fifth abdominal segment of these mutants to indistinguishable from that of a normal female. Other mutant combinations that produce fruitless courtship phenotypes—including deletion and inversion breakpoints, and a marked transposon inserted at 91B—produce intermediate forms of the MOL. A new genetic variant, induced by imprecise excision of the marked transposon, is homozygous lethal and disrupts fru functions related to courtship and the MOL. The MOL is shown to be dispensable for fertility and is therefore not the causative factor of fru-induced behavioral sterility. These genetic variants and their phenotypic results are discussed with regard to a model for the organization of the fru locus.

scholarly journals A GENETICALLY DISTINCT FORM OF CYCLIC AMP PHOSPHODIESTERASE ASSOCIATED WITH CHROMOMERE 3D4 IN DROSOPHILA MELANOGASTER

Genetics ◽  
1979 ◽  
Vol 91 (3) ◽  
pp. 521-535
Author(s):  
John A Kiger ◽  
Eric Golanty
Keyword(s):  
Drosophila Melanogaster ◽  
Cyclic Amp ◽  
Structural Gene ◽  
Regulatory Gene ◽  
Heat Stability ◽  
Normal Female ◽  
Dependent Manner ◽  
Cyclic Amp Phosphodiesterase ◽  
Heat Stable ◽  
Camp Levels

ABSTRACT Two cyclic AMP phosphodiesterase enzymes (E.C.3.1.4.17) are present in homogenates of adult Drosophila melanogaster. The two enzymes differ from one another in heat stability, affinity for Mg++, Ca++ activation and molecular weight. They do not differ markedly in their affinities for cyclic AMP, and both exhibit anomalous Michaelis-Menten kinetics. The more heatlabile enzyme is controlled in a dosage-dependent manner by chromomere 3D4 of the X chromosome and is absent in flies that are deficient for chromomere 3D4. Chromomere 3D4 is also necessary for the maintenance of normal cAMP levels, for male fertility, and for normal female fertility and oogenesis. The structural gene(s) for the more heat-stable enzyme is located outside of chromomeres 3C12-3D4. Whether 3D4 contains a structural gene, or a regulatory gene necessary for the presence of the labile enzyme, remains to be determined.

Sex hormone binding globulin stimulates female sexual receptivity

2000 ◽  
Vol 874 (1) ◽  
pp. 24-29 ◽  
Author(s):  
J.D. Caldwell ◽  
B.D. Moe ◽  
J. Hoang ◽  
T. Nguyen
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sexual Receptivity ◽  
Hormone Binding ◽  
Female Sexual Receptivity

scholarly journals Drosulfakinin signaling modulates female sexual receptivity in Drosophila

2021 ◽  
Author(s):  
Chuan Zhou ◽  
Tao Wang ◽  
Biyang Jing ◽  
Bowen Deng ◽  
Kai Shi ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Neuronal Activity ◽  
Input Signal ◽  
Sexual Receptivity ◽  
Innate Behavior ◽  
Female Sexual Behavior ◽  
Downstream Signaling ◽  
Biological Importance ◽  
Survival And Reproduction ◽  
Female Sexual Receptivity

Female sexual behavior as an innate behavior is of prominent biological importance for survival and reproduction. However, molecular and circuit mechanisms underlying female sexual behavior is not well understood. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) promotes female sexual behavior in Drosophila. Manipulation both Dsk and DSK neuronal activity impact female sexual receptivity. In addition, we reveal that Dsk-expressing neurons receive input signal from R71G01GAL4 neurons to promote female sexual receptivity. Based on intersectional technique, we further found the regulation of female sexual behavior relies mainly on medial DSK neurons rather than lateral DSK neurons, and medial DSK neurons modulate female sexual behavior by acting on its receptor CCKLR-17D3. Thus, we characterized DSK/CCKLR-17D3 as R71G01GAL4 neurons downstream signaling to regulate female sexual behavior.

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