scholarly journals "Silent" Metaplasticity of the Late Phase of Long-Term Potentiation Requires Protein Phosphatases

2002 ◽  
Vol 9 (4) ◽  
pp. 202-213 ◽  
Author(s):  
N. H. Woo
Keyword(s):  
Protein Phosphatases ◽  
Late Phase ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals The Role of Extracellular Regulated Kinases I/II in Late-Phase Long-Term Potentiation

2002 ◽  
Vol 22 (13) ◽  
pp. 5432-5441 ◽  
Author(s):  
Kobi Rosenblum ◽  
Marie Futter ◽  
Karen Voss ◽  
Muriel Erent ◽  
Paul A. Skehel ◽  
...  
Keyword(s):  
Late Phase ◽  
Long Term Potentiation ◽  
Term Potentiation

scholarly journals Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the Induction and Maintenance of Long-Term Potentiation

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1375 ◽  
Author(s):  
Przemysław Duda ◽  
Tomasz Wójtowicz ◽  
Jakub Janczara ◽  
Daniel Krowarsch ◽  
Aleksandra Czyrek ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Late Phase ◽  
Long Term Potentiation ◽  
Memory Formation ◽  
Lactate Shuttle ◽  
Term Potentiation ◽  
Fructose 1,6 Bisphosphatase ◽  
Nadh Ratio ◽  
Simultaneous Inhibition

Long-term potentiation (LTP) is a molecular basis of memory formation. Here, we demonstrate that LTP critically depends on fructose 1,6-bisphosphatase 2 (Fbp2)—a glyconeogenic enzyme and moonlighting protein protecting mitochondria against stress. We show that LTP induction regulates Fbp2 association with neuronal mitochondria and Camk2 and that the Fbp2–Camk2 interaction correlates with Camk2 autophosphorylation. Silencing of Fbp2 expression or simultaneous inhibition and tetramerization of the enzyme with a synthetic effector mimicking the action of physiological inhibitors (NAD+ and AMP) abolishes Camk2 autoactivation and blocks formation of the early phase of LTP and expression of the late phase LTP markers. Astrocyte-derived lactate reduces NAD+/NADH ratio in neurons and thus diminishes the pool of tetrameric and increases the fraction of dimeric Fbp2. We therefore hypothesize that this NAD+-level-dependent increase of the Fbp2 dimer/tetramer ratio might be a crucial mechanism in which astrocyte–neuron lactate shuttle stimulates LTP formation.

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