scholarly journals Sleep Deprivation Selectively Impairs Memory Consolidation for Contextual Fear Conditioning

2003 ◽  
Vol 10 (3) ◽  
pp. 168-176 ◽  
Author(s):  
L. A. Graves
Keyword(s):  
Sleep Deprivation ◽  
Fear Conditioning ◽  
Memory Consolidation ◽  
Contextual Fear Conditioning ◽  
Contextual Fear

THE CONTEXTUAL FEAR CONDITIONING DEFICIT INDUCED BY PARADOXICAL SLEEP DEPRIVATION IS ATTENUATED BY CLOZAPINE

2008 ◽  
Vol 102 (1-3) ◽  
pp. 142
Author(s):  
Raquel Levin ◽  
Mariana Calzavara ◽  
Wladimir Medrano ◽  
Antonio Frois ◽  
Roberto Frussa-Filho ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Fear Conditioning ◽  
Paradoxical Sleep ◽  
Contextual Fear Conditioning ◽  
Paradoxical Sleep Deprivation ◽  
Contextual Fear

scholarly journals Parvalbumin-positive interneurons mediate neocortical-hippocampal interactions that are necessary for memory consolidation

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Frances Xia ◽  
Blake A Richards ◽  
Matthew M Tran ◽  
Sheena A Josselyn ◽  
Kaori Takehara-Nishiuchi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Fear Conditioning ◽  
Medial Prefrontal Cortex ◽  
Memory Consolidation ◽  
Fear Memory ◽  
Contextual Fear Conditioning ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Spiking Activity

Following learning, increased coupling between spindle oscillations in the medial prefrontal cortex (mPFC) and ripple oscillations in the hippocampus is thought to underlie memory consolidation. However, whether learning-induced increases in ripple-spindle coupling are necessary for successful memory consolidation has not been tested directly. In order to decouple ripple-spindle oscillations, here we chemogenetically inhibited parvalbumin-positive (PV+) interneurons, since their activity is important for regulating the timing of spiking activity during oscillations. We found that contextual fear conditioning increased ripple-spindle coupling in mice. However, inhibition of PV+ cells in either CA1 or mPFC eliminated this learning-induced increase in ripple-spindle coupling without affecting ripple or spindle incidence. Consistent with the hypothesized importance of ripple-spindle coupling in memory consolidation, post-training inhibition of PV+ cells disrupted contextual fear memory consolidation. These results indicate that successful memory consolidation requires coherent hippocampal-neocortical communication mediated by PV+ cells.

Sleep deprivation impairs contextual fear conditioning and attenuates subsequent behavioural, endocrine and neuronal responses

2010 ◽  
Vol 20 (2) ◽  
pp. 259-266 ◽  
Author(s):  
ROELINA HAGEWOUD ◽  
LILLIAN J. BULTSMA ◽  
R. PAULIEN BARF ◽  
JAAP M. KOOLHAAS ◽  
PETER MEERLO
Keyword(s):  
Sleep Deprivation ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Neuronal Responses ◽  
Contextual Fear

scholarly journals A Time for Learning and a Time for Sleep: The Effect of Sleep Deprivation on Contextual Fear Conditioning at Different Times of the Day

SLEEP ◽  
2010 ◽  
Vol 33 (10) ◽  
pp. 1315-1322 ◽  
Author(s):  
Roelina Hagewoud ◽  
Shamiso N. Whitcomb ◽  
Amarins N. Heeringa ◽  
Robbert Havekes ◽  
Jaap M. Koolhaas ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Contextual Fear

Role of dorsal and ventral hippocampal muscarinic receptor activity in acquisition and retention of contextual fear conditioning.

2020 ◽  
Vol 134 (5) ◽  
pp. 460-470
Author(s):  
Claudia C. Pinizzotto ◽  
Nicholas A. Heroux ◽  
Colin J. Horgan ◽  
Mark E. Stanton
Keyword(s):  
Fear Conditioning ◽  
Muscarinic Receptor ◽  
Contextual Fear Conditioning ◽  
Receptor Activity ◽  
Contextual Fear
Sign in / Sign up

Export Citation Format

Share Document