scholarly journals Brief theta-burst stimulation induces a transcription-dependent late phase of LTP requiring cAMP in area CA1 of the mouse hippocampus.

1997 ◽  
Vol 4 (2) ◽  
pp. 230-243 ◽  
Author(s):  
P V Nguyen ◽  
E R Kandel
Keyword(s):  
Late Phase ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Area Ca1 ◽  
Mouse Hippocampus ◽  
Theta Burst

scholarly journals Augmenting saturated LTP by broadly spaced episodes of theta-burst stimulation in hippocampal area CA1 of adult rats and mice

2014 ◽  
Vol 112 (8) ◽  
pp. 1916-1924 ◽  
Author(s):  
Guan Cao ◽  
Kristen M. Harris
Keyword(s):  
Hippocampal Slices ◽  
Long Term Potentiation ◽  
Sprague Dawley ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Cellular Mechanisms ◽  
Adult Rats ◽  
Area Ca1 ◽  
Hippocampal Area ◽  
Theta Burst

Hippocampal long-term potentiation (LTP) is a model system for studying cellular mechanisms of learning and memory. Recent interest in mechanisms underlying the advantage of spaced over massed learning has prompted investigation into the effects of distributed episodes of LTP induction. The amount of LTP induced in hippocampal area CA1 by one train (1T) of theta-burst stimulation (TBS) in young Sprague-Dawley rats was further enhanced by additional bouts of 1T given at 1-h intervals. However, in young Long-Evans (LE) rats, 1T did not initially saturate LTP. Instead, a stronger LTP induction paradigm using eight trains of TBS (8T) induced saturated LTP in hippocampal slices from both young and adult LE rats as well as adult mice. The saturated LTP induced by 8T could be augmented by another episode of 8T following an interval of at least 90 min. The success rate across animals and slices in augmenting LTP by an additional episode of 8T increased significantly with longer intervals between the first and last episodes, ranging from 0% at 30- and 60-min intervals to 13–66% at 90- to 180-min intervals to 90–100% at 240-min intervals. Augmentation above initially saturated LTP was blocked by the N-methyl-d-aspartate (NMDA) glutamate receptor antagonist d-2-amino-5-phosphonovaleric acid (d-APV). These findings suggest that the strength of induction and interval between episodes of TBS, as well as the strain and age of the animal, are important components in the augmentation of LTP.

Effects of combined inhibitory and excitatory theta-burst stimulation in healthy subjects

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
AS Sarfeld ◽  
M Ameli ◽  
JT Teo ◽  
S Diekhoff ◽  
G Fink ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

30 Hz Theta-burst Stimulation Over Primary Somatosensory Cortex Modulates Corticospinal Output to the Hand

2014 ◽  
Vol 7 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Mark F. Jacobs ◽  
Philemon Tsang ◽  
Kevin G.H. Lee ◽  
Michael J. Asmussen ◽  
Christopher M. Zapallow ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Primary Somatosensory Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

Treatment of Auditory Hallucinations With Bilateral Theta Burst Stimulation: A Randomized Controlled Pilot Trial

2014 ◽  
Vol 7 (2) ◽  
pp. 340-341 ◽  
Author(s):  
Christian Plewnia ◽  
Bastian Zwissler ◽  
Barbara Wasserka ◽  
Andreas J. Fallgatter ◽  
Stefan Klingberg
Keyword(s):  
Pilot Trial ◽  
Auditory Hallucinations ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Randomized Controlled ◽  
Theta Burst

scholarly journals Therapeutic Use of Cerebellar Intermittent Theta Burst Stimulation (iTBS) in a Sardinian Family Affected by Spinocerebellar Ataxia 38 (SCA 38)

2021 ◽  
Author(s):  
Angela Sanna ◽  
Paolo Follesa ◽  
Paolo Tacconi ◽  
Mariangela Serra ◽  
Maria Giuseppina Pisu ◽  
...  
Keyword(s):  
Spinocerebellar Ataxia ◽  
Rating Scale ◽  
Clinical Symptoms ◽  
Therapeutic Use ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Motor Cortex Excitability ◽  
Before And After ◽  
Theta Burst ◽  
Serum Bdnf

AbstractSpinocerebellar ataxia 38 (SCA 38) is an autosomal dominant disorder caused by conventional mutations in the ELOVL5 gene which encodes an enzyme involved in the synthesis of very long fatty acids, with a specific expression in cerebellar Purkinje cells. Three Italian families carrying the mutation, one of which is of Sardinian descent, have been identified and characterized. One session of cerebellar intermittent theta burst stimulation (iTBS) was applied to 6 affected members of the Sardinian family to probe motor cortex excitability measured by motor-evoked potentials (MEPs). Afterwards, patients were exposed to ten sessions of cerebellar real and sham iTBS in a cross-over study and clinical symptoms were evaluated before and after treatment by Modified International Cooperative Ataxia Rating Scale (MICARS). Moreover, serum BDNF levels were evaluated before and after real and sham cerebellar iTBS and the role of BDNF Val66Met polymorphism in influencing iTBS effect was explored. Present data show that one session of cerebellar iTBS was able to increase MEPs in all tested patients, suggesting an enhancement of the cerebello-thalamo-cortical pathway in SCA 38. MICARS scores were reduced after ten sessions of real cerebellar iTBS showing an improvement in clinical symptoms. Finally, although serum BDNF levels were not affected by cerebellar iTBS when considering all samples, segregating for genotype a difference was found between Val66Val and Val66Met carriers. These preliminary data suggest a potential therapeutic use of cerebellar iTBS in improving motor symptoms of SCA38.

scholarly journals Intermittent Theta Burst Stimulation in Veterans with Mild Alcohol Use Disorder

2021 ◽  
Author(s):  
Melanie L. Bozzay ◽  
Sydney Brigido ◽  
Mascha van ’t Wout-Frank ◽  
Emily Aiken ◽  
Robert Swift ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst
Sign in / Sign up

Export Citation Format

Share Document