scholarly journals Cognitive and neural determinants of response strategy in the dual-solution plus-maze task

2011 ◽  
Vol 18 (4) ◽  
pp. 241-244 ◽  
Author(s):  
E. De Leonibus ◽  
V. J. A. Costantini ◽  
A. Massaro ◽  
G. Mandolesi ◽  
V. Vanni ◽  
...  
Keyword(s):  
Dual Solution ◽  
Response Strategy ◽  
Maze Task ◽  
Plus Maze

scholarly journals Low Protein Diet Induces Memory Loss and Anxiety Like Behavior via Decreases of Neurotransmitters in Aged Male Mice (P14-028-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Hideaki Sato ◽  
Masako Tsukamoto-Yasui ◽  
Satoko Ueno ◽  
Keiko Matsunaga ◽  
Akihiko Kitamura
Keyword(s):  
Cerebral Cortex ◽  
Memory Loss ◽  
The Elderly ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Avoidance Task ◽  
Maze Task ◽  
Low Protein ◽  
Plus Maze ◽  
The Brain

Abstract Objectives Increase of elderly people, dementia and cognitive decline has been already one of the social problems all over the world. There are a lot of risk factors including dietary composition. Several studies have reported the importance of protein for maintaining brain functions in the elderly, but the details are not well understood. To clarify the relationship between protein intake and brain function in the elderly, we evaluated the effect of low protein diet on cognitive function and psychiatric symptoms in aged mice. Methods Male mice at 60 weeks of age were fed a control diet (NPD; casein 20%) or a low protein diet (LPD; casein 5%). To evaluate neurobehavioral abnormality, we performed the elevated plus maze task (Day 64) and Passive avoidance task (conditioning: Day 66, evaluation: Day 67). Cerebral cortex tissues and plasma were measured for free amino acid concentration by LC-MSMS method, and monoamine concentration in cerebral cortex was measured by HPLC method. Results In the Passive avoidance task, LPD group decreased the time to keep staying in the light box and the rate of individuals entering the dark box during the test period. In the elevated plus maze task, LPD group significantly increased in the number of entry and staying times in open arm. In addition, total travel distance was significantly increased. Moreover, LPD decreased the concentration of not only amino acid in plasma and cerebral cortex but also neurotransmitter such as Glutamate, GABA, Aspartate, Glycine, Dopamine, Norepinephrine, Serotonin. Conclusions We found that long-term intake of low-protein diet occurred memory loss and anxiety like behavior in elderly mice. Intracerebral neurotransmitters are mainly synthesized from amino acids, which is transferred from blood, within the brain. Therefore, behavioral change observed in LPD group might be induced by the decrease of neurotransmitters in the brain. Funding Sources Ajinomoto Co., Inc.

scholarly journals Effects of the Essential Oil from Leaves of Alpinia zerumbet on Behavioral Alterations in Mice

2009 ◽  
Vol 4 (1) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Shio Murakami ◽  
Mariko Matsuura ◽  
Tadaaki Satou ◽  
Shinichiro Hayashi ◽  
Kazuo Koike
Keyword(s):  
Essential Oil ◽  
Mass Spectra ◽  
Elevated Plus Maze ◽  
Neuropsychiatric Symptoms ◽  
Retention Indices ◽  
Reproductive Hormone ◽  
Behavioral Alterations ◽  
Maze Task ◽  
Plus Maze ◽  
Alpinia Zerumbet

In phytotherapy, the essential oil from the leaves of Alpinia zerumbet ( Alpinia speciosa K. Schum.) (EOAZ) is used for neuropsychiatric symptoms, such as depression, stress and anxiety, and chronic problems that are associated with reproductive hormone imbalances in women. The chemical composition of EOAZ was analyzed by GC/MS, and the EOAZ properties inducing behavioral alterations in mice were examined by behavioral observations (BO) and an elevated plus-maze task (EPM), widely used as a method for assessing anxiolytic-like behaviors. Five major compounds, p-cymene (28.0 ± 5.0%), 1,8-cineole (17.9 ± 4.2%), terpinen-4-ol (11.9 ± 6.3%), limonene (6.3 ± 2.2%), and camphor (5.2 ± 2.1%) were identified by retention indices, mass spectra and comparison with standards. Inhalational administration of EOAZ (8.7 ppm) induced unique jumping behaviors in mice. To further investigate the behavioral regulatory mechanisms of EOAZ, we administered an intraperitoneal injection of either 10 mg/kg 5-HTP or 10 mg/kg fluoxetine prior to the EOAZ inhalations. By 5-HTP or fluoxetine pretreatments, the jumping frequencies were significantly decreased. In EPM, EOAZ (0.087 and 8.7 ppm) obviously showed the anxiolytic-like activity in mice.

Agmatine induces anxiolysis in the elevated plus maze task in adult rats

2003 ◽  
Vol 141 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Daniel Lavinsky ◽  
Nice Sarmento Arteni ◽  
Carlos Alexandre Netto
Keyword(s):  
Elevated Plus Maze ◽  
Maze Task ◽  
Adult Rats ◽  
Plus Maze

Effects of NOS inhibitors on the benzodiazepines-induced memory impairment of mice in the modified elevated plus-maze task

2013 ◽  
Vol 244 ◽  
pp. 100-106 ◽  
Author(s):  
Jolanta Orzelska ◽  
Sylwia Talarek ◽  
Joanna Listos ◽  
Sylwia Fidecka
Keyword(s):  
Memory Impairment ◽  
Elevated Plus Maze ◽  
Maze Task ◽  
Plus Maze ◽  
Nos Inhibitors

Behavioral Changes Induced by Angiotensin AT1 Receptors Blockade in the Rat Brain

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
L. Hritcu ◽  
W. Bild ◽  
A. Ciobica ◽  
V. Artenie ◽  
I. Haulica
Keyword(s):  
Angiotensin Ii ◽  
Elevated Plus Maze ◽  
Anxiety State ◽  
Avoidance Task ◽  
Maze Task ◽  
Term Memory ◽  
Y Maze ◽  
Plus Maze ◽  
The Brain

Aims:The brain renin-angiotensin system is involved in learning and memory, but the actual role of angiotensin II and its metabolites in this process has been difficult to comprehend. In the present study we assessed the role of the angiotensin AT1 receptors in certain behavioral effects of angiotensin II using their selective antagonist losartan and PD123319, intracerebroventricularly (icv) administrated.Methods:Male Wistar rats were divided into three groups: 1. sham-operated; 2. Losartan; 3. PD123319. All drugs were stereotaxically icv injected. Learning and memory tests began 2 weeks after the operation, and the ability of the rats to acquire the operant task was studied by means of Y-maze task and passive avoidance task, respectively. The anxiety state was measured in elevated plus maze.Results:Losartan and PD123319 significantly impaired spatial memory in Y-maze task, suggesting significant effects on short-term memory. In passive avoidance task, both angiotensin II antagonist, significantly decreased step-through-latency, suggesting significant effects on long-term memory. In elevated plus maze measuring anxiety, both drugs diminished anxiety state.Conclusions:Our results suggest the considerable involvement of the brain ATi angiotensin receptors in the cognition improving effects of angiotensin.

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