scholarly journals A second-generation combined linkage physical map of the human genome

2007 ◽  
Vol 17 (12) ◽  
pp. 1783-1786 ◽  
Author(s):  
T. C. Matise ◽  
F. Chen ◽  
W. Chen ◽  
F. M. De La Vega ◽  
M. Hansen ◽  
...  
Keyword(s):  
Human Genome ◽  
Second Generation ◽  
Physical Map

A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

10.1038/985 ◽  
1998 ◽  
Vol 19 (3) ◽  
pp. 292-296 ◽  
Author(s):  
Patrick Concannon ◽  
Kathryn J. Gogolin-Ewens ◽  
David A. Hinds ◽  
Beth Wapelhorst ◽  
V. Annem Morrison ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Human Genome ◽  
Second Generation ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

A second-generation linkage map of the human genome

Nature ◽  
1992 ◽  
Vol 359 (6398) ◽  
pp. 794-801 ◽  
Author(s):  
Jean Weissenbach ◽  
Gabor Gyapay ◽  
Colette Dib ◽  
Alain Vignal ◽  
Jean Morissette ◽  
...  
Keyword(s):  
Linkage Map ◽  
Human Genome ◽  
Second Generation

scholarly journals SunnyTALEN: A second-generation TALEN system for human genome editing

2013 ◽  
Vol 111 (4) ◽  
pp. 683-691 ◽  
Author(s):  
Ning Sun ◽  
Zehua Bao ◽  
Xiong Xiong ◽  
Huimin Zhao
Keyword(s):  
Human Genome ◽  
Genome Editing ◽  
Second Generation

scholarly journals A test case for physical mapping of human genome by repetitive sequence fingerprints: construction of a physical map of a 420 kb YAC subcloned into cosmids

1991 ◽  
Vol 19 (3) ◽  
pp. 505-510 ◽  
Author(s):  
C. Bellanné-Chantelot ◽  
E. Barillot ◽  
B. Lacroix ◽  
D.Le Paslier ◽  
D. Cohen
Keyword(s):  
Human Genome ◽  
Physical Mapping ◽  
Repetitive Sequence ◽  
Physical Map ◽  
Test Case

A first-generation physical map of the human genome

Nature ◽  
1993 ◽  
Vol 366 (6456) ◽  
pp. 698-701 ◽  
Author(s):  
D. Cohen ◽  
I. Chumakov ◽  
J. Weissenbach
Keyword(s):  
Human Genome ◽  
First Generation ◽  
Physical Map

scholarly journals SurVirus: a repeat-aware virus integration caller

2021 ◽  
Author(s):  
Ramesh Rajaby ◽  
Yi Zhou ◽  
Yifan Meng ◽  
Xi Zeng ◽  
Guoliang Li ◽  
...  
Keyword(s):  
Human Genome ◽  
High Throughput ◽  
High Throughput Sequencing ◽  
Second Generation ◽  
False Positives ◽  
The Other ◽  
False Negatives ◽  
Human Cancers ◽  
Human Genomes ◽  
Virus Integration

Abstract A significant portion of human cancers are due to viruses integrating into human genomes. Therefore, accurately predicting virus integrations can help uncover the mechanisms that lead to many devastating diseases. Virus integrations can be called by analysing second generation high-throughput sequencing datasets. Unfortunately, existing methods fail to report a significant portion of integrations, while predicting a large number of false positives. We observe that the inaccuracy is caused by incorrect alignment of reads in repetitive regions. False alignments create false positives, while missing alignments create false negatives. This paper proposes SurVirus, an improved virus integration caller that corrects the alignment of reads which are crucial for the discovery of integrations. We use publicly available datasets to show that existing methods predict hundreds of thousands of false positives; SurVirus, on the other hand, is significantly more precise while it also detects many novel integrations previously missed by other tools, most of which are in repetitive regions. We validate a subset of these novel integrations, and find that the majority are correct. Using SurVirus, we find that HPV and HBV integrations are enriched in LINE and Satellite regions which had been overlooked, as well as discover recurrent HBV and HPV breakpoints in human genome-virus fusion transcripts.

Piggy-BACing the Human Genome I: Constructing a Porcine BAC Physical Map Through Comparative Genomics

2008 ◽  
Vol 19 (1) ◽  
pp. 28-42 ◽  
Author(s):  
Margarita B. Rogatcheva ◽  
Kefei Chen ◽  
Denis M. Larkin ◽  
Stacey N. Meyers ◽  
Brandy M. Marron ◽  
...  
Keyword(s):  
Comparative Genomics ◽  
Human Genome ◽  
Physical Map

scholarly journals Second-Generation Genetic Linkage Map of Catfish and Its Integration with the BAC-Based Physical Map

2012 ◽  
Vol 2 (10) ◽  
pp. 1233-1241 ◽  
Author(s):  
Parichart Ninwichian ◽  
Eric Peatman ◽  
Hong Liu ◽  
Huseyin Kucuktas ◽  
Benjaporn Somridhivej ◽  
...  
Keyword(s):  
Linkage Map ◽  
Genetic Linkage ◽  
Second Generation ◽  
Genetic Linkage Map ◽  
Physical Map

scholarly journals A physical map of the human genome

Nature ◽  
2001 ◽  
Vol 409 (6822) ◽  
pp. 934-941 ◽  
Author(s):  
Keyword(s):  
Human Genome ◽  
Physical Map
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