scholarly journals Computational and Biological Analysis of 680 kb of DNA Sequence from the Human 5q31 Cytokine Gene Cluster Region

1997 ◽  
Vol 7 (5) ◽  
pp. 495-512 ◽  
Author(s):  
Kelly A. Frazer ◽  
Yukihiko Ueda ◽  
Yiwen Zhu ◽  
Vincent R. Gifford ◽  
Maria R. Garofalo ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Dna Sequence ◽  
Cytokine Gene ◽  
Cluster Region ◽  
Biological Analysis

scholarly journals Variants in the 5q31 cytokine gene cluster are associated with psoriasis

2007 ◽  
Vol 9 (2) ◽  
pp. 176-181 ◽  
Author(s):  
M Chang ◽  
Y Li ◽  
C Yan ◽  
K P Callis-Duffin ◽  
N Matsunami ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Cytokine Gene

scholarly journals Association of Nucleotide Polymorphisms within the O-Antigen Gene Cluster of Escherichia coli O26, O45, O103, O111, O121, and O145 with Serogroups and Genetic Subtypes

2012 ◽  
Vol 78 (18) ◽  
pp. 6689-6703 ◽  
Author(s):  
Keri N. Norman ◽  
Nancy A. Strockbine ◽  
James L. Bono
Keyword(s):  
Escherichia Coli ◽  
Gene Cluster ◽  
Dna Sequence ◽  
Shiga Toxin ◽  
Severe Disease ◽  
The United States ◽  
Effective Control ◽  
Nucleotide Polymorphisms ◽  
Antigen Gene ◽  
O Antigen

ABSTRACTShiga toxin-producingEscherichia coli(STEC) strains are important food-borne pathogens capable of causing hemolytic-uremic syndrome. STEC O157:H7 strains cause the majority of severe disease in the United States; however, there is a growing concern for the amount and severity of illness attributable to non-O157 STEC. Recently, the Food Safety and Inspection Service (FSIS) published the intent to regulate the presence of STEC belonging to serogroups O26, O45, O103, O111, O121, and O145 in nonintact beef products. To ensure the effective control of these bacteria, sensitive and specific tests for their detection will be needed. In this study, we identified single nucleotide polymorphisms (SNPs) in the O-antigen gene cluster that could be used to detect STEC strains of the above-described serogroups. Using comparative DNA sequence analysis, we identified 22 potentially informative SNPs among 164 STEC and non-STEC strains of the above-described serogroups and designed matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF) assays to test the STEC allele frequencies in an independent panel of bacterial strains. We found at least one SNP that was specific to each serogroup and also differentiated between STEC and non-STEC strains. Differences in the DNA sequence of the O-antigen gene cluster corresponded well with differences in the virulence gene profiles and provided evidence of different lineages for STEC and non-STEC strains. The SNPs discovered in this study can be used to develop tests that will not only accurately identify O26, O45, O103, O111, O121, and O145 strains but also predict whether strains detected in the above-described serogroups contain Shiga toxin-encoding genes.

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

2001 ◽  
Vol 29 (2) ◽  
pp. 223-228 ◽  
Author(s):  
John D. Rioux ◽  
Mark J. Daly ◽  
Mark S. Silverberg ◽  
Kerstin Lindblad ◽  
Hillary Steinhart ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Gene Cluster ◽  
Crohn Disease ◽  
Cytokine Gene

scholarly journals Isolation and molecular characterization of a urease-negative Actinobacillus pleuropneumoniae mutant

2017 ◽  
Vol 30 (1) ◽  
pp. 172-174 ◽  
Author(s):  
Hiroya Ito ◽  
Sayaka Takahashi ◽  
Tetsuo Asai ◽  
Yutaka Tamura ◽  
Koshi Yamamoto
Keyword(s):  
Sequence Analysis ◽  
Nucleotide Sequence ◽  
Gene Cluster ◽  
Molecular Characterization ◽  
Dna Sequence ◽  
Actinobacillus Pleuropneumoniae ◽  
Nucleotide Sequence Analysis ◽  
Urease Gene ◽  
Negative Mutant

An atypical urease-negative mutant of Actinobacillus pleuropneumoniae serovar 2 was isolated in Japan. Nucleotide sequence analysis of the urease gene cluster revealed that the insertion of a short DNA sequence into the cbiM gene was responsible for the urease-negative activity of the mutant. Veterinary diagnostic laboratories should be watchful for the presence of aberrant urease-negative A. pleuropneumoniae isolates.

DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa

1989 ◽  
Vol 207 (1) ◽  
pp. 15-34 ◽  
Author(s):  
Robert F. Geever ◽  
Layne Huiet ◽  
James A. Baum ◽  
Brett M. Tyler ◽  
Virginia B. Patel ◽  
...  
Keyword(s):  
Neurospora Crassa ◽  
Gene Cluster ◽  
Dna Sequence ◽  
Sequence Organization ◽  
Dna Sequence Organization

scholarly journals Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria

2009 ◽  
Vol 8 (1) ◽  
pp. 232 ◽  
Author(s):  
Izumi Naka ◽  
Nao Nishida ◽  
Jintana Patarapotikul ◽  
Pornlada Nuchnoi ◽  
Katsushi Tokunaga ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Severe Malaria ◽  
Haplotype Block ◽  
Cytokine Gene
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