scholarly journals The Generic Genome Browser: A Building Block for a Model Organism System Database

2002 ◽  
Vol 12 (10) ◽  
pp. 1599-1610 ◽  
Author(s):  
L. D. Stein
Keyword(s):  
Building Block ◽  
Model Organism ◽  
Genome Browser ◽  
System Database ◽  
Generic Genome ◽  
Generic Genome Browser

scholarly journals Choosing a genome browser for a Model Organism Database: surveying the Maize community

Database ◽  
2010 ◽  
Vol 2010 ◽  
Author(s):  
Taner Z. Sen ◽  
Lisa C. Harper ◽  
Mary L. Schaeffer ◽  
Carson M. Andorf ◽  
Trent E. Seigfried ◽  
...  
Keyword(s):  
Model Organism ◽  
Genome Browser ◽  
Model Organism Database ◽  
A Genome

Zebrafish as model organism for craniosynostosis

2017 ◽  
Author(s):  
Rabea Bluemel ◽  
Eva Klopocki ◽  
Daniel Liedtke
Keyword(s):  
Model Organism

Microbe Engineering of Guaia-6,10(14)-diene as a Building Block for the Semisynthetic Production of Plant-Derived (−)-Englerin A

2019 ◽  
Author(s):  
Thomas Siemon ◽  
Zhangqian Wang ◽  
Guangkai Bian ◽  
Tobias Seitz ◽  
Ziling Ye ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Saccharomyces Cerevisiae ◽  
Synthetic Biology ◽  
Chemical Synthesis ◽  
Building Block ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Economical Method ◽  
Englerin A ◽  
Transient Receptor

Herein, we report the semisynthetic production of the potent transient receptor potential canonical (TRPC) channel agonist (−)-englerin A (EA), using guaia-6,10(14)-diene as the starting material. Guaia-6,10(14)-diene was systematically engineered in Escherichia coli and Saccharomyces cerevisiae using the CRISPR/Cas9 system and produced with high titers. This provided us the opportunity to execute a concise chemical synthesis of EA and the two related guaianes (−)-oxyphyllol and (+)-orientalol E. The potentially scalable approach combines the advantages of synthetic biology and chemical synthesis and provides an efficient and economical method for producing EA as well as its analogs.

Sign in / Sign up

Export Citation Format

Share Document