scholarly journals Multi-species microarrays reveal the effect of sequence divergence on gene expression profiles

2005 ◽  
Vol 15 (5) ◽  
pp. 674-680 ◽  
Author(s):  
Y. Gilad
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Sequence Divergence ◽  
Gene Expression Profiles

scholarly journals Sexually dimorphic gene expression and transcriptome evolution provides mixed evidence for a fast-Z effect in Heliconius

2018 ◽  
Author(s):  
A Pinharanda ◽  
M Rousselle ◽  
SH Martin ◽  
JJ Hanly ◽  
JW Davey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Molecular Evolution ◽  
Adaptive Evolution ◽  
Sex Chromosomes ◽  
Expression Profiles ◽  
Sequence Divergence ◽  
Gene Expression Profiles ◽  
Purifying Selection ◽  
Specific Gene ◽  
Sex Determination System

AbstractSex chromosomes have different evolutionary properties as compared to the autosomes due to their hemizygous nature. In particular, recessive mutations are more readily exposed to selection, which can lead to faster rates of molecular evolution. Here, we report patterns of gene expression and molecular evolution in the sex chromosomes of a group of tropical butterflies. We first improved the completeness of the Heliconius melpomene reference annotation, a neotropical butterfly with a ZW sex determination system. Then we sequenced RNA from male and female whole abdomens and female ovary and gut tissue to identify sex and tissue specific gene expression profiles in H. melpomene. Using these expression profiles we compare sequence divergence and polymorphism, the strength of positive and negative selection and rates of adaptive evolution for Z and autosomal genes between two species of Heliconius butterflies, H. melpomene and H. erato.We show that the rate of adaptive substitutions is higher for Z as compared to autosomal genes, but contrary to expectation it is also higher for male as compared to female biased genes. There is therefore mixed evidence that hemizygosity influences the rate of adaptive substitutions. Additionally, we find no significant increase in the rate of adaptive evolution or purifying selection on genes expressed in ovary tissue, a heterogametic specific tissue. Together our results provide limited support for fast-Z evolution. This contributes to a growing body of literature from other ZW systems that also provide mixed evidence for a fast-Z effect.

1327: Gene Expression Profiles in Benign Prostatic Hyperplasia

2004 ◽  
Vol 171 (4S) ◽  
pp. 349-350
Author(s):  
Gaelle Fromont ◽  
Michel Vidaud ◽  
Alain Latil ◽  
Guy Vallancien ◽  
Pierre Validire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Benign Prostatic Hyperplasia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Prostatic Hyperplasia
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