scholarly journals The 22q11 low copy repeats are characterized by unprecedented size and structural variability

2019 ◽  
Vol 29 (9) ◽  
pp. 1389-1401 ◽  
Author(s):  
Wolfram Demaerel ◽  
Yulia Mostovoy ◽  
Feyza Yilmaz ◽  
Lisanne Vervoort ◽  
Steven Pastor ◽  
...  
Keyword(s):  
Structural Variability ◽  
Low Copy Repeats

Structural variability and thermally-induced mesomorphisms in complexes of copper(II) with 4-halobenzoates, 2,2'-bipyridine and 4,4'-bis(dodecyl)-2,2'-bipyridine

2021 ◽  
pp. 1-18
Author(s):  
Norbani Abdullah ◽  
Lailatun N. Ozair ◽  
Habibah Samsudin ◽  
Graham J. Tizzard ◽  
Simon J. Coles ◽  
...  
Keyword(s):  
Thermally Induced ◽  
Structural Variability

Rationalizing the Structural Variability of the Exocyclic Amino Groups in Nucleobases and Their Metal Complexes: Cytosine and Adenine

2014 ◽  
Vol 20 (31) ◽  
pp. 9494-9499 ◽  
Author(s):  
Célia Fonseca Guerra ◽  
Pablo J. Sanz Miguel ◽  
Andrea Cebollada ◽  
F. Matthias Bickelhaupt ◽  
Bernhard Lippert
Keyword(s):  
Metal Complexes ◽  
Amino Groups ◽  
Structural Variability

scholarly journals Rearrangements of the Williams–Beuren syndrome locus: molecular basis and implications for speech and language development

2007 ◽  
Vol 9 (15) ◽  
pp. 1-16 ◽  
Author(s):  
Lucy R. Osborne ◽  
Carolyn B. Mervis
Keyword(s):  
Language Development ◽  
Language Impairment ◽  
Short Term Memory ◽  
Relative Strength ◽  
Genomic Rearrangements ◽  
Speech And Language ◽  
Human Speech ◽  
Hyperactivity Disorder ◽  
Low Copy Repeats ◽  
Speech And Language Development

AbstractThe Williams–Beuren syndrome (WBS) locus on human chromosome 7q11.23 is flanked by complex chromosome-specific low-copy repeats that mediate recurrent genomic rearrangements of the region. Common genomic rearrangements arise through unequal meiotic recombination and result in complex but distinct behavioural and cognitive phenotypes. Deletion of 7q11.23 results in WBS, which is characterised by mild to moderate intellectual disability or learning difficulties, with relative cognitive strengths in verbal short-term memory and in language and extreme weakness in visuospatial construction, as well as anxiety, attention-deficit hyperactivity disorder and overfriendliness. By contrast, duplication results in severely delayed speech and expressive language, with relative strength in visuospatial construction. Although deletion and duplication of the WBS region have very different effects, both cause forms of language impairment and suggest that dosage-sensitive genes within the region are important for the proper development of human speech and language. The spectrum and frequency of genomic rearrangements at 7q11.23 presents an exceptional opportunity to identify gene(s) directly involved in human speech and language development.

Structural diversity of salts of terpyridine derivatives with europium(III) located in both, cation and anion, in comparison to molecular complexes

2020 ◽  
Vol 235 (8-9) ◽  
pp. 353-363
Author(s):  
Alexander E. Sedykh ◽  
Robin Bissert ◽  
Dirk G. Kurth ◽  
Klaus Müller-Buschbaum
Keyword(s):  
Thermal Properties ◽  
Crystal Packing ◽  
Side Reaction ◽  
Molecular Complexes ◽  
Structural Diversity ◽  
Organic Ligands ◽  
Ionic Complexes ◽  
Structural Variability ◽  
Dimeric Complexes ◽  
The Common

AbstractThree salts of the common composition [EuCl2(X-tpy)2][EuCl4(X-tpy)]·nMeCN were obtained from EuCl3·6H2O and the respective organic ligands (X-tpy = 4′-phenyl-2,2′:6′,2″-terpyridine ptpy, 4′-(pyridin-4-yl)-2,2′:6′,2″-terpyridine 4-pytpy, and 4′-(pyridin-3-yl)-2,2′:6′,2″-terpyridine 3-pytpy). These ionic complexes are examples of salts, in which both cation and anion contain Eu3+ with the same organic ligands and chlorine atoms coordinated. As side reaction, acetonitrile transforms into acetamide resulting in the crystallization of the complex [EuCl3(ptpy)(acetamide)] (4). Salts [EuCl2(ptpy)2][EuCl4(ptpy)]·2.34MeCN (1), [EuCl2(4-pytpy)2][EuCl4(4-pytpy)]·0.11MeCN (2), and [EuCl2(3-pytpy)2][EuCl4(3-pytpy)]·MeCN (3) crystallize in different structures (varying in space group and crystal packing) due to variation of the rear atom of the ligand to a coordinative site. Additionally, we show and compare structural variability through the dimeric complexes [Eu2Cl6(ptpy)2(N,N′-spacer)]·N,N′-spacer (5, 6, 7) obtained from [EuCl3(ptpy)(py)] by exchanging the end-on ligand pyridine with several bipyridines (4,4′-bipyridine bipy, 1,2-bis(4-pyridyl)ethane bpa, and 1,2-bis(2-pyridyl)ethylene bpe). In addition, photophysical (photoluminescence) and thermal properties are presented.

Density Functional Theory and X-ray Analysis of the Structural Variability in η5,η5,η1-Tris(ring) Rare Earth/Actinide Tetramethylpyrrolyl Complexes, (C5Me5)2M(NC4Me4)

2012 ◽  
Vol 52 (7) ◽  
pp. 3565-3572 ◽  
Author(s):  
Christopher L. Webster ◽  
Jefferson E. Bates ◽  
Ming Fang ◽  
Joseph W. Ziller ◽  
Filipp Furche ◽  
...  
Keyword(s):  
Density Functional Theory ◽  
Rare Earth ◽  
Density Functional ◽  
Functional Theory ◽  
X Ray ◽  
Structural Variability

Betalomonosovite: chemical and structural variability and genesis

2018 ◽  
Vol 30 (2) ◽  
pp. 289-304 ◽  
Author(s):  
Inna S. Lykova ◽  
Nikita V. Chukanov ◽  
Igor V. Pekov ◽  
Vasiliy O. Yapaskurt ◽  
Gerald Giester
Keyword(s):  
Structural Variability

scholarly journals Structural Variability of CD44v Molecules and Reliability of Immunodetection of CD44 Isoforms Using mAbs Specific for CD44 Variant Exon Products

1999 ◽  
Vol 154 (1) ◽  
pp. 291-300 ◽  
Author(s):  
Marco Paolo Martegani ◽  
Fabrizio Del Prete ◽  
Alessandra Gasbarri ◽  
Pier Giorgio Natali ◽  
Armando Bartolazzi
Keyword(s):  
Cd44 Isoforms ◽  
Variant Exon ◽  
Cd44 Variant ◽  
Structural Variability

A Convergent Synthetic Route to (+)-Dynemicin A and Analogs of Wide Structural Variability

1997 ◽  
Vol 119 (26) ◽  
pp. 6072-6094 ◽  
Author(s):  
Andrew G. Myers ◽  
Norma J. Tom ◽  
Mark E. Fraley ◽  
Scott B. Cohen ◽  
David J. Madar
Keyword(s):  
Synthetic Route ◽  
Structural Variability
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