scholarly journals Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)

2018 ◽  
Vol 28 (10) ◽  
pp. 1508-1519 ◽  
Author(s):  
Jonas Ungerbäck ◽  
Hiroyuki Hosokawa ◽  
Xun Wang ◽  
Tobias Strid ◽  
Brian A. Williams ◽  
...  
Keyword(s):  
Gene Regulation ◽  
T Cell ◽  
Chromatin Remodeling ◽  
Cell Gene

scholarly journals ATP-dependent chromatin remodeling in T cells1This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process.

2012 ◽  
Vol 90 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Andrea L. Wurster ◽  
Michael J. Pazin
Keyword(s):  
Gene Regulation ◽  
T Cell ◽  
Cell Fate ◽  
Chromatin Remodeling ◽  
Peer Review Process ◽  
T Cell Development ◽  
Cell Development ◽  
Compare And Contrast ◽  
Cell Gene ◽  
Present Understanding

One of the best studied systems for mammalian chromatin remodeling is transcriptional regulation during T cell development. The variety of these studies have led to important findings in T cell gene regulation and cell fate determination. Importantly, these findings have also advanced our knowledge of the function of remodeling enzymes in mammalian gene regulation. First we briefly present biochemical and cell-free analysis of 3 types of ATP dependent remodeling enzymes (SWI/SNF, Mi2, and ISWI) to construct an intellectual framework to understand how these enzymes might be working. Second, we compare and contrast the function of these enzymes during early (thymic) and late (peripheral) T cell development. Finally, we examine some of the gaps in our present understanding.

scholarly journals Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

2009 ◽  
Vol 183 (3) ◽  
pp. 1695-1704 ◽  
Author(s):  
Pujya Agarwal ◽  
Arvind Raghavan ◽  
Sarada L. Nandiwada ◽  
Julie M. Curtsinger ◽  
Paul R. Bohjanen ◽  
...  
Keyword(s):  
Gene Regulation ◽  
T Cell ◽  
Chromatin Remodeling ◽  
Cd8 T Cell ◽  
Effector Function ◽  
Type I ◽  
Type I Ifn ◽  
Cell Effector Function ◽  
Cell Effector

Posttranscriptional T cell gene regulation to limit Tfh cells and autoimmunity

2015 ◽  
Vol 37 ◽  
pp. 21-27 ◽  
Author(s):  
Simon H Jiang ◽  
Nan Shen ◽  
Carola G Vinuesa
Keyword(s):  
Gene Regulation ◽  
T Cell ◽  
Tfh Cells ◽  
Cell Gene

scholarly journals Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2313
Author(s):  
Suk-Ling Ma ◽  
Junyi Wu ◽  
Liuying Zhu ◽  
Ruth Chan ◽  
Amy Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Lower Limb ◽  
Exercise Program ◽  
Lower Limb Muscle ◽  
Limb Muscle ◽  
Strength Performance ◽  
Leg Extension ◽  
Cell Gene Expression ◽  
Cell Gene

Background: Sarcopenia is a major health problem in older adults. Exercise and nutrient supplementation have been shown to be effective interventions but there are limited studies to investigate their effects on the management of sarcopenia and its possible underlying mechanisms. Here, we studied T cell gene expression responses to interventions in sarcopenia. Methods: The results of this study were part of a completed trial examining the effectiveness of a 12-week intervention with exercise and nutrition supplementation in community-dwelling Chinese older adults with sarcopenia, based on the available blood samples at baseline and 12 weeks from 46 randomized participants from three study groups, namely: exercise program alone (n = 11), combined-exercise program and nutrition supplement (n = 23), and waitlist control group (n = 12). T cell gene expression was evaluated, with emphasis on inflammation-related genes. Real-time PCR (RT-PCR) was performed on CD3 T cells in 38 selected genes. Correlation analysis was performed to relate the results of gene expression analysis with lower limb muscle strength performance, measured using leg extension tests. Results: Our results showed a significant improvement in leg extension for both the exercise program alone and the combined groups (p < 0.001). Nine genes showed significant pre- and post-difference in gene expression over 12 weeks of intervention in the combined group. Seven genes (RASGRP1, BIN1, LEF1, ANXA6, IL-7R, LRRN3, and PRKCQ) showed an interaction effect between intervention and gene expression levels on leg extension in the confirmatory analysis, with confounder variables controlled and FDR correction. Conclusions: Our findings showed that T cell-specific inflammatory gene expression was changed significantly after 12 weeks of intervention with combined exercise and HMB supplementation in sarcopenia, and that this was associated with lower limb muscle strength performance.

The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription

Development ◽  
1999 ◽  
Vol 126 (4) ◽  
pp. 733-742 ◽  
Author(s):  
M. Vazquez ◽  
L. Moore ◽  
J.A. Kennison
Keyword(s):  
Gene Regulation ◽  
Chromatin Remodeling ◽  
Homeotic Gene ◽  
Dna Binding Domain ◽  
Atpase Subunit ◽  
Trithorax Group ◽  
Chromatin Remodeling Complex ◽  
P2 Promoter ◽  
Domain Protein ◽  
Arid Domain

The trithorax group gene brahma (brm) encodes the ATPase subunit of a chromatin-remodeling complex involved in homeotic gene regulation. We report here that brm interacts with another trithorax group gene, osa, to regulate the expression of the Antennapedia P2 promoter. Regulation of Antennapedia by BRM and OSA proteins requires sequences 5′ to the P2 promoter. Loss of maternal osa function causes severe segmentation defects, indicating that the function of osa is not limited to homeotic gene regulation. The OSA protein contains an ARID domain, a DNA-binding domain also present in the yeast SWI1 and Drosophila DRI proteins. We propose that the OSA protein may target the BRM complex to Antennapedia and other regulated genes.

scholarly journals Identification of a T cell gene expression clock obtained by exploiting a MZ twin design

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Daniel Remondini ◽  
Nathan Intrator ◽  
Claudia Sala ◽  
Michela Pierini ◽  
Paolo Garagnani ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Twin Design ◽  
Cell Gene Expression ◽  
Cell Gene

scholarly journals 767. A Novel Humanized Mouse Model for Testing Anti-HIV T-Cell Gene Therapy Strategies

2016 ◽  
Vol 24 ◽  
pp. S304
Author(s):  
Kevin G. Haworth ◽  
Christina Ironside ◽  
Hans-Peter Kiem
Keyword(s):  
Gene Therapy ◽  
T Cell ◽  
Mouse Model ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Therapy Strategies ◽  
Cell Gene ◽  
Anti Hiv
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