Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance

P. Jia; H. Jin; C. B. Meador; J. Xia; K. Ohashi; L. Liu; V. Pirazzoli; K. B. Dahlman; K. Politi; F. Michor; Z. Zhao; W. Pao

doi:10.1101/gr.152322.112

Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance

Genome Research ◽

10.1101/gr.152322.112 ◽

2013 ◽

Vol 23 (9) ◽

pp. 1434-1445 ◽

Cited By ~ 33

Author(s):

P. Jia ◽

H. Jin ◽

C. B. Meador ◽

J. Xia ◽

K. Ohashi ◽

...

Keyword(s):

Lung Cancer ◽

Drug Resistance ◽

Next Generation Sequencing ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Cell Lines ◽

Kinase Inhibitor ◽

Lung Cancer Cell ◽

Egfr Mutant ◽

Generation Sequencing

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Calpain4 Regulates The Response Of Non-Small Cell Lung Cancer Cell Lines To EGFR Tyrosine Kinase Inhibitor Erlotinib

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6288 ◽

2012 ◽

Author(s):

Sucheta Kulkarni ◽

Leya Saju ◽

Carol F. Farver

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Small Cell Lung Cancer ◽

Tyrosine Kinase Inhibitor ◽

Cell Lines ◽

Kinase Inhibitor ◽

Small Cell ◽

Lung Cancer Cell ◽

Small Cell Lung ◽

Egfr Tyrosine Kinase Inhibitor

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The Combination of Multiple Receptor Tyrosine Kinase Inhibitor and Mammalian Target of Rapamycin Inhibitor Overcomes Erlotinib Resistance in Lung Cancer Cell Lines through c-Met Inhibition

Molecular Cancer Research ◽

10.1158/1541-7786.mcr-09-0388 ◽

2010 ◽

Vol 8 (8) ◽

pp. 1142-1151 ◽

Cited By ~ 19

Author(s):

Ichiro Nakachi ◽

Katsuhiko Naoki ◽

Kenzo Soejima ◽

Ichiro Kawada ◽

Hideo Watanabe ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Cell Lines ◽

Cancer Cell ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitor ◽

Mammalian Target Of Rapamycin ◽

Lung Cancer Cell ◽

Multiple Receptor

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399 POSTER Synergistic antitumor activity of the combination of the multi-targeted tyrosine kinase inhibitor sorafenib and of EGFR inhibitors in human colon and lung cancer cell lines

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(06)70404-9 ◽

2006 ◽

Vol 4 (12) ◽

pp. 123 ◽

Cited By ~ 5

Author(s):

E. Martinelli ◽

T. Troiani ◽

G. Laus ◽

S. Pepe ◽

F. Ciardiello

Keyword(s):

Lung Cancer ◽

Antitumor Activity ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Cell Lines ◽

Cancer Cell ◽

Kinase Inhibitor ◽

Human Colon ◽

Lung Cancer Cell ◽

Synergistic Antitumor Activity

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Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines

PLoS ONE ◽

10.1371/journal.pone.0004576 ◽

2009 ◽

Vol 4 (2) ◽

pp. e4576 ◽

Cited By ~ 144

Author(s):

Jeet Gandhi ◽

Jianling Zhang ◽

Yang Xie ◽

Junichi Soh ◽

Hisayuki Shigematsu ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Cell Lines ◽

Cancer Cell ◽

Kinase Inhibitor ◽

Egfr Signaling ◽

Lung Cancer Cell ◽

Egfr Tyrosine Kinase Inhibitor ◽

Egfr Signaling Pathway

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The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 (‘Iressa’11Iressa’ is a trademark of the AstraZeneca group of companies.) is not related to the expression of EGFR or HER-2 or to K-ras gene status

Lung Cancer ◽

10.1016/s0169-5002(03)00278-2 ◽

2003 ◽

Vol 42 (1) ◽

pp. 35-41 ◽

Cited By ~ 53

Author(s):

Takeshi Suzuki ◽

Taku Nakagawa ◽

Hideki Endo ◽

Tetsuya Mitsudomi ◽

Akira Masuda ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Cell Lines ◽

Cancer Cell ◽

Kinase Inhibitor ◽

Lung Cancer Cell ◽

Ras Gene ◽

Her 2 ◽

Gene Status

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Egfr-Tyrosine Kinase Inhibitor (Tki) Rechallenge with Bevacizumab in Egfr-Mutant Non-Small Cell Lung Cancer (Nsclc)

Annals of Oncology ◽

10.1093/annonc/mdu349.65 ◽

2014 ◽

Vol 25 ◽

pp. iv452

Author(s):

K. Otsuka ◽

A. Hata ◽

R. Kato ◽

J. Takeshita ◽

C. Okuda ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Small Cell Lung Cancer ◽

Tyrosine Kinase Inhibitor ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Small Cell ◽

Small Cell Lung ◽

Egfr Tyrosine Kinase Inhibitor ◽

Egfr Mutant

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Met Kinase Inhibitor E7050 Reverses Three Different Mechanisms of Hepatocyte Growth Factor-Induced Tyrosine Kinase Inhibitor Resistance in EGFR Mutant Lung Cancer

Annals of Oncology ◽

10.1016/s0923-7534(20)32299-7 ◽

2012 ◽

Vol 23 ◽

pp. xi111

Author(s):

T. Nakagawa ◽

S. Takeuchi ◽

T. Yamada ◽

S. Yano

Keyword(s):

Lung Cancer ◽

Growth Factor ◽

Hepatocyte Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Kinase Inhibitor ◽

Egfr Mutant ◽

Inhibitor Resistance ◽

Hepatocyte Growth

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Abstract B57: MUC3A induces PD-L1 and reduces tyrosine kinase inhibitor effects functions in EGFR-mutant non-small cell lung cancer

10.1158/2326-6074.tumimm19-b57 ◽

2020 ◽

Author(s):

Yan Gong ◽

Yuan Luo ◽

Shan Peng ◽

Shijing Ma ◽

Yingming Sun ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Small Cell Lung Cancer ◽

Tyrosine Kinase Inhibitor ◽

Cell Lung Cancer ◽

Kinase Inhibitor ◽

Small Cell ◽

Small Cell Lung ◽

Egfr Mutant

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1284P MET inhibitor capmatinib plus EGFR tyrosine kinase inhibitor nazartinib for EGFR-mutant non-small cell lung cancer

Annals of Oncology ◽

10.1016/j.annonc.2020.08.1598 ◽

2020 ◽

Vol 31 ◽

pp. S829-S830

Author(s):

E. Felip ◽

V. Minotti ◽

R. Soo ◽

J. Wolf ◽

B. Solomon ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Small Cell Lung Cancer ◽

Tyrosine Kinase Inhibitor ◽

Kinase Inhibitor ◽

Small Cell ◽

Small Cell Lung ◽

Egfr Tyrosine Kinase Inhibitor ◽

Met Inhibitor ◽

Egfr Mutant

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Detection of BCR-ABL1 mutations that confer tyrosine kinase inhibitor resistance using massively parallel, next generation sequencing

Annals of Hematology ◽

10.1007/s00277-015-2539-0 ◽

2015 ◽

Vol 95 (2) ◽

pp. 201-210 ◽

Cited By ~ 7

Author(s):

Philippe Szankasi ◽

Jonathan A. Schumacher ◽

Todd W. Kelley

Keyword(s):

Next Generation Sequencing ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Kinase Inhibitor ◽

Massively Parallel ◽

Next Generation ◽

Inhibitor Resistance ◽

Generation Sequencing

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