scholarly journals Clcn4-2 genomic structure differs between the X locus in Mus spretus and the autosomal locus in Mus musculus: AT motif enrichment on the X

2011 ◽  
Vol 21 (3) ◽  
pp. 402-409 ◽  
Author(s):  
D. K. Nguyen ◽  
F. Yang ◽  
R. Kaul ◽  
C. Alkan ◽  
A. Antonellis ◽  
...  
Keyword(s):  
Mus Musculus ◽  
Genomic Structure ◽  
Autosomal Locus ◽  
Mus Spretus ◽  
Motif Enrichment

Use of Metallomics in Environmental Pollution Assessment Using Mice Mus musculus/Mus spretus as Bioindicators

2013 ◽  
Vol 9 (2) ◽  
pp. 229-243
Author(s):  
M. Gonzalez-Fernandez ◽  
M. Angel Garcia-Sevillano ◽  
R. Jara-Biedma ◽  
F. Navarro- Roldn ◽  
T. Garcia-Barrera ◽  
...  
Keyword(s):  
Environmental Pollution ◽  
Mus Musculus ◽  
Pollution Assessment ◽  
Mus Spretus

Use of Metallomics in Environmental Pollution Assessment Using Mice Mus musculus/Mus spretus as Bioindicators

2013 ◽  
Vol 9 (2) ◽  
pp. 229-243 ◽  
Author(s):  
M. Gonzalez-Fernandez ◽  
M. Angel Garcia-Sevillano ◽  
R. Jara-Biedma ◽  
F. Navarro- Roldán ◽  
T. Garcia-Barrera ◽  
...  
Keyword(s):  
Environmental Pollution ◽  
Mus Musculus ◽  
Pollution Assessment ◽  
Mus Spretus

Gene flow of unique sequences between Mus musculus domesticus and Mus spretus

2000 ◽  
Vol 11 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Rhonda Greene-Till ◽  
Yingping Zhao ◽  
Stephen C. Hardies
Keyword(s):  
Gene Flow ◽  
Mus Musculus ◽  
Mus Musculus Domesticus ◽  
Mus Spretus

scholarly journals Spermatozoa telomeres determine telomere length in early embryos and offspring

Reproduction ◽  
2016 ◽  
Vol 151 (1) ◽  
pp. 1-7 ◽  
Author(s):  
C de Frutos ◽  
A P López-Cardona ◽  
N Fonseca Balvís ◽  
R Laguna-Barraza ◽  
D Rizos ◽  
...  
Keyword(s):  
Telomere Length ◽  
Mus Musculus ◽  
Mus Spretus ◽  
Cell Stage ◽  
Young Males ◽  
Early Embryos ◽  
Parent Of Origin ◽  
Telomere Lengthening ◽  
Zygote Stage

Offspring telomere length (TL) has been correlated with paternal TL, but the mechanism for this parent of origin-specific inheritance remains unclear. The objective of this study has been to determine the role of spermatozoa TL in embryonic telomere lengthening by using two mouse models showing dimorphism in their spermatozoa TL: Mus musculus vs Mus spretus and old vs young Mus musculus. Mus spretus spermatozoa displayed a shorter TL than Mus musculus. Hybrid offspring exhibited lower TL compared with Mus musculus starting at the two-cell stage, before the onset of telomerase expression. To analyze the role of spermatozoa telomeres in early telomere lengthening, we compared the TL in oocytes, zygotes, two-cell embryos and blastocysts produced by parthenogenesis or by fertilization with Mus musculus or Mus spretus spermatozoa. TL was significantly higher in spermatozoa compared with oocytes, and it increased significantly from the oocyte to the zygote stage in those embryos fertilized with Mus musculus spermatozoa, but not in those fertilized with Mus spretus spermatozoa or produced by parthenogenesis. A further increase was noted from the zygote to the two-cell stage in fertilized Mus musculus embryos, whereas hybrid embryos maintained the oocyte TL. Spermatozoa TL shortened with age in Mus musculus and the offspring from young males showed a significantly higher TL compared with that fathered by old males. These significant differences were already noticeable at the two-cell stage. These results suggest that spermatozoa telomeres act as a guide for telomerase-independent telomere lengthening resulting in differences in TL that persist after birth.Free Spanish abstract: A Spanish translation of this abstract is freely available at http://www.reproduction-online.org/content/151/1/1/suppl/DC1.

scholarly journals Evidence of evolutionary up-regulation of the single active X chromosome in mammals based on Clc4 expression levels in Mus spretus and Mus musculus

1997 ◽  
Vol 94 (17) ◽  
pp. 9244-9248 ◽  
Author(s):  
D. A. Adler ◽  
E. I. Rugarli ◽  
P. A. Lingenfelter ◽  
K. Tsuchiya ◽  
D. Poslinski ◽  
...  
Keyword(s):  
X Chromosome ◽  
Mus Musculus ◽  
Mus Spretus ◽  
Expression Levels

The rodents from the late middle Pleistocene hominid-bearing site of J'bel Irhoud, Morocco, and their chronological and paleoenvironmental implications

2013 ◽  
Vol 80 (3) ◽  
pp. 552-561 ◽  
Author(s):  
Denis Geraads ◽  
Fethi Amani ◽  
Abdelouahed Ben-Ncer ◽  
Shannon P. McPherron ◽  
Jean-Paul Raynal ◽  
...  
Keyword(s):  
North Africa ◽  
Mus Musculus ◽  
Diversity Indices ◽  
Middle Pleistocene ◽  
Early Age ◽  
Mus Spretus ◽  
Upper Pleistocene ◽  
Living Species ◽  
Favorable Conditions ◽  
Late Middle Pleistocene

The rodents from the late middle Pleistocene hominin-bearing locality of J'bel Irhoud include the following species: Meriones shawii, Gerbillus grandis, Dipodillus campestris, Paraethomys ras, Lemniscomys barbarus, Mus cf. spretus, and Eliomys sp. We consider M. shawii, a living species, as identical with the middle Pleistocene Meriones maghrebianus. The mouse differs from the domestic Mus musculus but does not clearly fit into Mus spretus, either. The rare G. grandis looks identical with the form from the middle Pleistocene of Thomas quarries, which may suggest a rather early age for Irhoud. This is in agreement with the occurrence of Paraethomys, a genus unknown in the upper Pleistocene of Morocco, but the absence of the arvicolid Ellobius suggests that the site is younger than other middle Pleistocene sites, Doukkala II, Sidi Abderrahmane D2, and Irhoud-Derbala-Virage. Paleoecological indicators, such as the taxonomic habitat spectrum, or the relative abundances of Gerbillinae and Murinae, suggest a less xeric environment than in many earlier and later sites. Diversity indices, comparable to those of other middle Pleistocene sites, point to similarly favorable conditions before the major climatic crisis close to the middle/upper Pleistocene boundary that drastically reduced rodent diversity in North Africa.

scholarly journals Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses

2015 ◽  
Vol 89 (21) ◽  
pp. 10879-10890 ◽  
Author(s):  
Judith Verhelst ◽  
Jan Spitaels ◽  
Cindy Nürnberger ◽  
Dorien De Vlieger ◽  
Tine Ysenbaert ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Antiviral Activity ◽  
Influenza A Virus ◽  
Mus Musculus ◽  
Influenza A ◽  
Common Mechanism ◽  
Mus Spretus ◽  
Influenza A Viruses ◽  
Content Type ◽  
Mouse Species

ABSTRACTThe interferon-inducedMx1gene is an important part of the mammalian defense against influenza viruses.Mus musculusMx1 inhibits influenza A virus replication and transcription by suppressing the polymerase activity of viral ribonucleoproteins (vRNPs). Here, we compared the anti-influenza virus activity of Mx1 fromMus musculusA2G with that of its ortholog fromMus spretus. We found that the antiviral activity ofM. spretusMx1 was less potent than that ofM. musculusMx1. Comparison of theM. musculusMx1 sequence with theM. spretusMx1 sequence revealed 25 amino acid differences, over half of which were present in the GTPase domain and 2 of which were present in loop L4. However, thein vitroGTPase activity of Mx1 from the two mouse species was similar. Replacement of one of the residues in loop L4 inM. spretusMx1 by the corresponding residue of A2G Mx1 increased its antiviral activity. We also show that deletion of loop L4 prevented the binding of Mx1 to influenza A virus nucleoprotein and, hence, abolished the antiviral activity of mouse Mx1. These results indicate that loop L4 of mouse Mx1 is a determinant of antiviral activity. Our findings suggest that Mx proteins from different mammals use a common mechanism to inhibit influenza A viruses.IMPORTANCEMx proteins are evolutionarily conserved in vertebrates and inhibit a wide range of viruses. Still, the exact details of their antiviral mechanisms remain largely unknown. Functional comparison of theMxgenes from two species that diverged relatively recently in evolution can provide novel insights into these mechanisms. We show that bothMus musculusA2G Mx1 andMus spretusMx1 target the influenza virus nucleoprotein. We also found that loop L4 in mouse Mx1 is crucial for its antiviral activity, as was recently reported for primate MxA. This indicates that human and mouse Mx proteins, which have diverged by 75 million years of evolution, recognize and inhibit influenza A viruses by a common mechanism.

scholarly journals NEURON-SPECIFIC CHROMOSOMAL MEGADOMAIN ORGANIZATION IS ADAPTIVE TO RECENT RETROTRANSPOSON EXPANSIONS

2021 ◽  
Author(s):  
Sandhya Chandrasekaran ◽  
Sergio Espeso-Gil ◽  
Yong-Hwee Eddie Loh ◽  
Behnam Javidfar ◽  
Bibi Kassim ◽  
...  
Keyword(s):  
Mus Musculus ◽  
Endogenous Retrovirus ◽  
Cellular Stress Response ◽  
Chromatin Domain ◽  
Open Chromatin ◽  
Mus Spretus ◽  
Stress Response Genes ◽  
Mouse Cerebral Cortex ◽  
Mature Neurons ◽  
Cell Type Specific

ABSTRACTHere, we mapped cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong enrichment of Endogenous Retrovirus 2 (ERV2) repeat sequences in the neuron-specific heterochromatic ‘B2NeuN+’ megabase-scaling subcompartment. Comparative chromosomal conformation mapping in Mus spretus and Mus musculus revealed neuron-specific reconfigurations tracking recent ERV2 retrotransposon expansions in the murine germline, with significantly higher B2 megadomain contact frequencies at sites with ongoing ERV2 insertions in Mus musculus. Ablation of the retrotransposon silencer Kmt1e/Setdb1 triggered B2 megadomain disintegration and rewiring with open chromatin domains enriched for cellular stress response genes, along with severe neuroinflammation and proviral assembly of ERV2/Intracisternal-A-Particles (IAPs) infiltrating dendrites and spines. We conclude that neuronal megadomain architectures include evolutionarily adaptive heterochromatic organization which, upon perturbation, unleashes ERV proviruses with strong tropism within mature neurons.

Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus implies positive selection

1993 ◽  
Vol 38 (2) ◽  
Author(s):  
Evan Hermel ◽  
PeterJ. Robinson ◽  
Jin-Xiong She ◽  
Kirstein Fischer Lindahl
Keyword(s):  
Positive Selection ◽  
Mus Musculus ◽  
Sequence Divergence ◽  
Mus Spretus
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