scholarly journals The 10q25 Neocentromere and its Inactive Progenitor Have Identical Primary Nucleotide Sequence: Further Evidence for Epigenetic Modification

2000 ◽  
Vol 10 (6) ◽  
pp. 832-838 ◽  
Author(s):  
A. E. Barry
Keyword(s):  
Nucleotide Sequence ◽  
Epigenetic Modification ◽  
Primary Nucleotide Sequence

scholarly journals The primary nucleotide sequence of nuclear U-2 ribonucleic acid. The 5'-terminal portion of the molecule.

1975 ◽  
Vol 250 (10) ◽  
pp. 3909-3920 ◽  
Author(s):  
H Shibata ◽  
TS Ro-Choi ◽  
R Reddy ◽  
YC Choi ◽  
D Henning ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Ribonucleic Acid ◽  
Terminal Portion ◽  
Primary Nucleotide Sequence

scholarly journals The primary nucleotide sequence of U4 RNA.

1981 ◽  
Vol 256 (7) ◽  
pp. 3532-3538
Author(s):  
R. Reddy ◽  
D. Henning ◽  
H. Busch
Keyword(s):  
Nucleotide Sequence ◽  
U4 Rna ◽  
Primary Nucleotide Sequence

Identification of a functional role for the 3′ region of the human oestrogen receptor gene

1993 ◽  
Vol 10 (2) ◽  
pp. 143-152 ◽  
Author(s):  
M Keaveney ◽  
M G Parker ◽  
F Gannon
Keyword(s):  
Nucleotide Sequence ◽  
Untranslated Region ◽  
Functional Role ◽  
Oestrogen Receptor ◽  
Regulatory Mechanism ◽  
Receptor Gene ◽  
Expression Vectors ◽  
Flanking Sequence ◽  
Primary Nucleotide Sequence ◽  
Receptor Gene Family

ABSTRACT A well-conserved feature of the steroid receptor gene family is the presence of an exceptionally long 3′ untranslated region (UTR). Analysis of this sequence from the human oestrogen receptor (hER) gene showed the presence of a number of AT-rich regions that included thirteen repeats of the ATTTA motif, an element known to have a destabilizing effect in other systems. In the region 3′ of the gene there were a further eight copies of this pentamer. Also located in this sequence were two members of the Alu repetitive family in inverse orientation and in a tandem arrangement. Transfection experiments in which the 3′ UTR and 3′ flanking sequence were included in chloramphenicol acetyltransferase expression vectors revealed a large destabilization effect with several different fragments. This inherent instability appears to be determined by the primary nucleotide sequence but may act in conjunction with other factors. This posttranscriptional regulatory mechanism may contribute to the control of the level of the hER mRNA.

scholarly journals Hysteresis and conformational changes in ribosomal ribonucleic acid

1972 ◽  
Vol 126 (4) ◽  
pp. 1039-1054 ◽  
Author(s):  
R. A. Cox ◽  
A. Katchalsky
Keyword(s):  
Escherichia Coli ◽  
Free Energy ◽  
Sodium Chloride ◽  
Nucleotide Sequence ◽  
Conformational Changes ◽  
Acidic Solutions ◽  
Ribosomal Ribonucleic Acid ◽  
Energy Dissipated ◽  
Boundary Curves ◽  
Primary Nucleotide Sequence

Both rat liver and Escherichia coli rRNA in 0.1m-sodium chloride were titrated with acid or alkali over the range pH3–7 at approx. 0°C. rRNA did not bind acid reversibly and hysteresis was observed, i.e. the plot of acid bound to rRNA against pH had the form of a loop showing that the amount of acid bound at a particular pH depended on the direction of the titration. Although the boundary curves were reproducibly followed on titration from pH7 to 3 and from pH3 to 7, points within the loop were ‘scanned’, e.g. by titration from pH7 to a point in the range pH3–4 followed by titration with alkali to pH7. It is inferred that the ‘lag’ in the release of certain bound protons is at least 1 pH unit, that at least about 9–15% of the titratable groups (adenine and cytosine residues) that are involved in this process and that the free energy dissipated in completing a cycle is approx. 4.2kJ/mol (1kcal/mol) of nucleotide involved in hysteresis. The interpretation of the ‘scanning’ curves was illustrated by means of a cycle of possible changes in the conformation of a hypothetical nucleotide sequence that allows formation of poly(A)·poly(AαH+)-like regions in acidic solutions. It is also inferred that the extent of ‘hysteresis’ might depend on the primary nucleotide sequence of rRNA as well as on secondary structure.

Human cytokine gene nucleotide sequence alignments, 1998

1998 ◽  
Vol 25 (2‐3) ◽  
pp. 83-265 ◽  
Author(s):  
J. L. Bidwell ◽  
N. A. P. Wood ◽  
H. R. Morse ◽  
O. O. Olomolaiye ◽  
G. J. Laundy
Keyword(s):  
Nucleotide Sequence ◽  
Cytokine Gene ◽  
Sequence Alignments ◽  
Gene Nucleotide Sequence ◽  
Human Cytokine
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