scholarly journals Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction

2009 ◽  
Vol 23 (19) ◽  
pp. 2278-2283 ◽  
Author(s):  
N. Kogata ◽  
R. M. Tribe ◽  
R. Fassler ◽  
M. Way ◽  
R. H. Adams
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Vascular Wall ◽  
Cell Contraction ◽  
Wall Formation ◽  
Integrin Linked Kinase

scholarly journals Dexamethasone induces rapid promotion of norepinephrine-mediated vascular smooth muscle cell contraction

2012 ◽  
Vol 7 (2) ◽  
pp. 549-554 ◽  
Author(s):  
TING ZHANG ◽  
WEN-LEI SHI ◽  
JEFFREY G. TASKER ◽  
JIANG-RUI ZHOU ◽  
YUN-LI PENG ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Contraction

scholarly journals Integrin-Linked Kinase in the Vascular Smooth Muscle Cell Response to Injury

2008 ◽  
Vol 173 (1) ◽  
pp. 278-288 ◽  
Author(s):  
Bernard Ho ◽  
Guangpei Hou ◽  
J. Geoffrey Pickering ◽  
Gregory Hannigan ◽  
B. Lowell Langille ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Response ◽  
Integrin Linked Kinase

Ticagrelor, but not clopidogrel and prasugrel, prevents ADP-induced vascular smooth muscle cell contraction: A placebo-controlled study in rats

2012 ◽  
Vol 130 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Grzegorz Grzesk ◽  
Marek Kozinski ◽  
Eliano Pio Navarese ◽  
Marek Krzyzanowski ◽  
Elzbieta Grzesk ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Controlled Study ◽  
Cell Contraction

scholarly journals Vascular smooth muscle cell contraction and relaxation in the isolated aorta: a critical regulator of large artery compliance

2019 ◽  
Vol 7 (4) ◽  
pp. e13934 ◽  
Author(s):  
Arthur J. A. Leloup ◽  
Cor E. Van Hove ◽  
Sofie De Moudt ◽  
Guido R. Y. De Meyer ◽  
Gilles W. De Keulenaer ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Large Artery ◽  
Cell Contraction ◽  
Isolated Aorta ◽  
Contraction And Relaxation

Chemokine receptor–8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion

Blood ◽  
2004 ◽  
Vol 103 (4) ◽  
pp. 1296-1304 ◽  
Author(s):  
Nasreen S. Haque ◽  
John T. Fallon ◽  
Jiang Jin Pan ◽  
Mark B. Taubman ◽  
Peter C. Harpel
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Chemokine Receptor ◽  
Umbilical Vein ◽  
Vascular Wall ◽  
Vsmc Proliferation ◽  
Cc Chemokine

Abstract The response of the arterial vascular wall to injury is characterized by vascular smooth muscle cell (VSMC) migration, a process requiring metalloproteinase production. This migration is induced by cytokines, however the agonists involved are not fully defined. The CC chemokine receptor 8 (CCR8) is expressed on monocytes and T lymphocytes and is the sole receptor for the human CC chemokine 1 (CCL1, I-309) and for the viral chemokine, vCCL1 (viral macrophage inflammatory protein 1 [vMIP-1]). We have reported that CCR8 is expressed on human umbilical vein endothelial cells (HUVECs) and mediates chemotaxis induced by CCL1. The conditioned medium from incubation mixtures of lipoprotein(a) (Lp(a)) and HUVECs (LCM) contained CCL1 and stimulated both monocyte and HUVEC chemotaxis, providing novel mechanisms for the atherogenicity of Lp(a). We now report that CCL1, vCCL1, and LCM stimulate chemotaxis of human VSMCs that is blocked by murine monoclonal antibody against CCR8 and by the G-protein inhibitor pertussis toxin. The effect of anti-CCR8 was specific, as this antibody failed to effect the chemotaxis of VSMCs in response to CCL3 or by platelet-derived growth factor BB (PDGF-BB). VSMCs contained CCR8 mRNA and CCR8 antigen coprecipitated with VSMC membranes. Antibodies against metalloproteinase-2 (MMP-2) inhibited the CCL1-induced chemotaxis of VSMCs, whereas anti–MMP-9 was less effective. CCL1 induced VSMC pro–MMP-2 mRNA and protein secretion. Poxvirus MC148 inhibited the increase in MMP-2 induced by CCL1, documenting that CCR8 was the receptor responsible. In mouse femoral arteries, CCR8 and TCA3 antigen colocalized with VSMCs and were up-regulated after injury. The induction of CCR8 and CCL1/TCA3 under conditions associated with VSMC proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology.

scholarly journals Role for G 12 /G 13 in Agonist-Induced Vascular Smooth Muscle Cell Contraction

2000 ◽  
Vol 87 (3) ◽  
pp. 221-227 ◽  
Author(s):  
Antje Gohla ◽  
Günter Schultz ◽  
Stefan Offermanns
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Contraction ◽  
G 12 ◽  
G 13
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