scholarly journals Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice.

1991 ◽  
Vol 5 (4) ◽  
pp. 642-655 ◽  
Author(s):  
M P Mullen ◽  
C W Smith ◽  
J G Patton ◽  
B Nadal-Ginard
Keyword(s):  
Exclusive Exon

Origin and evolution of a new exon of 14-3-3ξ in bees and phylogenetic analysis

Genome ◽  
2013 ◽  
Vol 56 (4) ◽  
pp. 233-237
Author(s):  
Leilei Zhan ◽  
Chao Jiang
Keyword(s):  
Phylogenetic Analysis ◽  
Parasitic Wasp ◽  
Nasonia Vitripennis ◽  
Origin And Evolution ◽  
Hymenopteran Species ◽  
Alternatively Spliced ◽  
Corbiculate Bees ◽  
Exclusive Exon ◽  
Alternatively Spliced Exons ◽  
Selection Of

Mutually exclusive splicing, one type of alternative splicing, involves selection of alternatively spliced exons arranged in tandem and creates protein products with substitution of one segment of the amino acid sequence for another. Previous studies revealed that exon 5 of 14-3-3ξ from Apis mellifera (western honeybee) had three mutually exclusive exons, while orthologous exon of Nasonia vitripennis (parasitic wasp) had only two, suggesting that cases of exon gain or loss might have happened during the evolution of hymenopteran species. In the current study, we annotated and analyzed the 14-3-3ξ genes from 20 hymenopteran species successfully, and the results of phylogenetic analysis revealed the presence of a new mutually exclusive exon in corbiculate bees. In addition, we found that duplication via staggered homologous recombination was responsible for the origin of the new exon.

scholarly journals Mutually exclusive exon use and reactive center diversity in insect serpins.

1994 ◽  
Vol 269 (1) ◽  
pp. 55-58
Author(s):  
H. Jiang ◽  
Y. Wang ◽  
M.R. Kanost
Keyword(s):  
Reactive Center ◽  
Exclusive Exon

scholarly journals Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon.

1994 ◽  
Vol 13 (16) ◽  
pp. 3861-3872 ◽  
Author(s):  
C. Gooding ◽  
G.C. Roberts ◽  
G. Moreau ◽  
B. Nadal-Ginard ◽  
C.W. Smith
Keyword(s):  
Smooth Muscle ◽  
Specific Inhibition ◽  
Exclusive Exon

scholarly journals Biological impact of mutually exclusive exon switching

2021 ◽  
Vol 17 (3) ◽  
pp. e1008708
Author(s):  
Su Datt Lam ◽  
M. Madan Babu ◽  
Jonathan Lees ◽  
Christine A. Orengo
Keyword(s):  
Alternative Splicing ◽  
Structural Properties ◽  
Protein Function ◽  
Large Scale ◽  
Large Scale Structure ◽  
Protein Fold ◽  
Protein Surface ◽  
Biological Impact ◽  
Functional Sites ◽  
Exclusive Exon

Alternative splicing can expand the diversity of proteomes. Homologous mutually exclusive exons (MXEs) originate from the same ancestral exon and result in polypeptides with similar structural properties but altered sequence. Why would some genes switch homologous exons and what are their biological impact? Here, we analyse the extent of sequence, structural and functional variability in MXEs and report the first large scale, structure-based analysis of the biological impact of MXE events from different genomes. MXE-specific residues tend to map to single domains, are highly enriched in surface exposed residues and cluster at or near protein functional sites. Thus, MXE events are likely to maintain the protein fold, but alter specificity and selectivity of protein function. This comprehensive resource of MXE events and their annotations is available at: http://gene3d.biochem.ucl.ac.uk/mxemod/. These findings highlight how small, but significant changes at critical positions on a protein surface are exploited in evolution to alter function.

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