scholarly journals Arabidopsis JACKDAW and MAGPIE zinc finger proteins delimit asymmetric cell division and stabilize tissue boundaries by restricting SHORT-ROOT action

2007 ◽  
Vol 21 (17) ◽  
pp. 2196-2204 ◽  
Author(s):  
D. Welch ◽  
H. Hassan ◽  
I. Blilou ◽  
R. Immink ◽  
R. Heidstra ◽  
...  
Keyword(s):  
Cell Division ◽  
Zinc Finger ◽  
Asymmetric Cell Division ◽  
Zinc Finger Proteins ◽  
Short Root

scholarly journals Arabidopsis BIRD Zinc Finger Proteins Jointly Stabilize Tissue Boundaries by Confining the Cell Fate Regulator SHORT-ROOT and Contributing to Fate Specification

2015 ◽  
Vol 27 (4) ◽  
pp. 1185-1199 ◽  
Author(s):  
Yuchen Long ◽  
Wouter Smet ◽  
Alfredo Cruz-Ramírez ◽  
Bas Castelijns ◽  
Wim de Jonge ◽  
...  
Keyword(s):  
Cell Fate ◽  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
Short Root ◽  
Fate Specification

scholarly journals SCHIZORIZA controls an asymmetric cell division and restricts epidermal identity in the Arabidopsis root

Development ◽  
2002 ◽  
Vol 129 (18) ◽  
pp. 4327-4334 ◽  
Author(s):  
Panagiota Mylona ◽  
Paul Linstead ◽  
Rob Martienssen ◽  
Liam Dolan
Keyword(s):  
Cell Division ◽  
Asymmetric Cell Division ◽  
Primary Root ◽  
Root Hairs ◽  
Ground Tissue ◽  
Short Root ◽  
Arabidopsis Root ◽  
Radial Patterning ◽  
Radial Cell ◽  
Layered Ground

The primary root of Arabidopsis has a simple cellular organisation. The fixed radial cell pattern results from stereotypical cell divisions that occur in the meristem. Here we describe the characterisation of schizoriza (scz), a mutant with defective radial patterning. In scz mutants, the subepidermal layer (ground tissue) develops root hairs. Root hairs normally only form on epidermal cells of wild-type plants. Moreover, extra periclinal divisions (new wall parallel to surface of the root) occur in the scz root resulting in the formation of supernumerary layers in the ground tissue. Both scarecrow (scr) and short root (shr) suppress the extra periclinal divisions characteristic of scz mutant roots. This results in the formation of a single layered ground tissue in the double mutants. Cells of this layer develop root hairs, indicating that mis-specification of the ground tissue in scz mutants is uncoupled to the cell division defect. This suggests that during the development of the ground tissue SCZ has two distinct roles: (1) it acts as a suppressor of epidermal fate in the ground tissue, and (2) it is required to repress periclinal divisions in the meristem. It may act in the same pathway as SCR and SHR.

Centromere assembly and non-random sister chromatid segregation in stem cells

2020 ◽  
Vol 64 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Ben L. Carty ◽  
Elaine M. Dunleavy
Keyword(s):  
Stem Cells ◽  
Cell Division ◽  
Cell Fate ◽  
Sister Chromatid ◽  
Asymmetric Cell Division ◽  
Protein A ◽  
Germline Stem Cells ◽  
Sister Chromatids ◽  
Centromere Protein A ◽  
Oocyte Meiosis

Abstract Asymmetric cell division (ACD) produces daughter cells with separate distinct cell fates and is critical for the development and regulation of multicellular organisms. Epigenetic mechanisms are key players in cell fate determination. Centromeres, epigenetically specified loci defined by the presence of the histone H3-variant, centromere protein A (CENP-A), are essential for chromosome segregation at cell division. ACDs in stem cells and in oocyte meiosis have been proposed to be reliant on centromere integrity for the regulation of the non-random segregation of chromosomes. It has recently been shown that CENP-A is asymmetrically distributed between the centromeres of sister chromatids in male and female Drosophila germline stem cells (GSCs), with more CENP-A on sister chromatids to be segregated to the GSC. This imbalance in centromere strength correlates with the temporal and asymmetric assembly of the mitotic spindle and potentially orientates the cell to allow for biased sister chromatid retention in stem cells. In this essay, we discuss the recent evidence for asymmetric sister centromeres in stem cells. Thereafter, we discuss mechanistic avenues to establish this sister centromere asymmetry and how it ultimately might influence cell fate.

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