scholarly journals Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3 

2004 ◽  
Vol 18 (3) ◽  
pp. 261-277 ◽  
Author(s):  
L. Qu
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Cytoplasmic Localization

scholarly journals Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Liang Luo ◽  
Tangfeng Lv ◽  
Qian Wang ◽  
Ting Zhang ◽  
Xiaoling Gu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protein C ◽  
Glycogen Synthase ◽  
Umbilical Vein ◽  
Activated Protein C ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

This study investigated the relationship between antiapoptotic activities induced by activated protein C and endoplasmic reticulum stress. In this study, it was observed that activated protein C elicited a rise in glucose-regulated protein 78 and glycogen synthase kinase-3βand inhibited apoptosis in human umbilical vein endothelial cells induced by lipopolysaccharide. Calcium inhibition did not alter the antiapoptotic effect of activated protein C. The antiapoptotic efficiency of activated protein C was reduced in human umbilical vein endothelial cells following treatment with glycogen synthase kinase-3β-siRNA. In summary, activated protein C induced endoplasmic reticulum stress and attenuated lipopolysaccharide-induced human umbilical vein endothelial cell apoptosis mediated by glycogen synthase kinase-3β.

scholarly journals Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells

2011 ◽  
Vol 317 (11) ◽  
pp. 1621-1628 ◽  
Author(s):  
Gordon P. Meares ◽  
Marjelo A. Mines ◽  
Eléonore Beurel ◽  
Tae-Yeon Eom ◽  
Ling Song ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Glycogen Synthase ◽  
Neuronal Cells ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Chop Expression
Sign in / Sign up

Export Citation Format

Share Document