scholarly journals Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor

2003 ◽  
Vol 17 (23) ◽  
pp. 2875-2888 ◽  
Author(s):  
J. M. Bolduc
Keyword(s):  
Rna Binding ◽  
Homing Endonuclease ◽  
Group I Intron ◽  
Splicing Factor ◽  
Intron Splicing ◽  
Dna And Rna ◽  
Group I ◽  
Biochemical Analyses ◽  
Dna And Rna Binding

scholarly journals A Tyrosyl-tRNA Synthetase Adapted to Function in Group I Intron Splicing by Acquiring a New RNA Binding Surface

2005 ◽  
Vol 17 (3) ◽  
pp. 417-428 ◽  
Author(s):  
Paul J. Paukstelis ◽  
Robert Coon ◽  
Lakshmi Madabusi ◽  
Jacek Nowakowski ◽  
Arthur Monzingo ◽  
...  
Keyword(s):  
Rna Binding ◽  
Group I Intron ◽  
Trna Synthetase ◽  
Intron Splicing ◽  
Group I ◽  
Binding Surface

Alteration of DNA and RNA Binding Activity of Human Telomere Binding Proteins Occurs during Cellular Senescence

1995 ◽  
Vol 218 (1) ◽  
pp. 241-247 ◽  
Author(s):  
Karen Hubbard ◽  
Sridevi N. Dhanaraj ◽  
Khalid A. Sethi ◽  
Janice Rhodes ◽  
Jeffrey Wilusz ◽  
...  
Keyword(s):  
Cellular Senescence ◽  
Binding Proteins ◽  
Rna Binding ◽  
Binding Activity ◽  
Dna And Rna ◽  
Human Telomere ◽  
Dna And Rna Binding

scholarly journals Borrelia burgdorferiSpoVG DNA- and RNA-Binding Protein Modulates the Physiology of the Lyme Disease Spirochete

2018 ◽  
Vol 200 (12) ◽  
Author(s):  
Christina R. Savage ◽  
Brandon L. Jutras ◽  
Aaron Bestor ◽  
Kit Tilly ◽  
Patricia A. Rosa ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Rna Binding ◽  
Culture Conditions ◽  
Altered Expression ◽  
Content Type ◽  
Protein Levels ◽  
Dna And Rna ◽  
Physiological Alterations ◽  
Bacterial Replication ◽  
Dna And Rna Binding

ABSTRACTThe SpoVG protein ofBorrelia burgdorferi, the Lyme disease spirochete, binds to specific sites of DNA and RNA. The bacterium regulates transcription ofspoVGduring the natural tick-mammal infectious cycle and in response to some changes in culture conditions. Bacterial levels ofspoVGmRNA and SpoVG protein did not necessarily correlate, suggesting that posttranscriptional mechanisms also control protein levels. Consistent with this, SpoVG binds to its own mRNA, adjacent to the ribosome-binding site. SpoVG also binds to two DNA sites in theglpFKDoperon and to two RNA sites inglpFKDmRNA; that operon encodes genes necessary for glycerol catabolism and is important for colonization in ticks. In addition, spirochetes engineered to dysregulatespoVGexhibited physiological alterations.IMPORTANCEB. burgdorferipersists in nature by cycling between ticks and vertebrates. Little is known about how the bacterium senses and adapts to each niche of the cycle. The present studies indicate thatB. burgdorfericontrols production of SpoVG and that this protein binds to specific sites of DNA and RNA in the genome and transcriptome, respectively. Altered expression ofspoVGexerts effects on bacterial replication and other aspects of the spirochete's physiology.

scholarly journals A novel mechanism for protein-assisted group I intron splicing

RNA ◽  
2002 ◽  
Vol 8 (4) ◽  
pp. 412-425 ◽  
Author(s):  
AMANDA SOLEM ◽  
PIYALI CHATTERJEE ◽  
MARK G. CAPRARA
Keyword(s):  
Group I Intron ◽  
Intron Splicing ◽  
Group I
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