Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook

2021 ◽  
pp. a040782
Author(s):  
Devon Davidian ◽  
Michael Levin
Keyword(s):  
Limb Regeneration ◽  
Future Outlook ◽  
Vertebrate Limb

scholarly journals Melanocortin Receptor 4 Signaling Regulates Vertebrate Limb Regeneration

2018 ◽  
Vol 46 (4) ◽  
pp. 397-409.e5 ◽  
Author(s):  
Mengshi Zhang ◽  
Youwei Chen ◽  
Hanqian Xu ◽  
Li Yang ◽  
Feng Yuan ◽  
...  
Keyword(s):  
Limb Regeneration ◽  
Melanocortin Receptor ◽  
Vertebrate Limb

scholarly journals Author response: Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

2020 ◽  
Author(s):  
Konstantinos Sousounis ◽  
Donald M Bryant ◽  
Jose Martinez Fernandez ◽  
Samuel S Eddy ◽  
Stephanie L Tsai ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Cell Cycle Progression ◽  
Limb Regeneration ◽  
Author Response ◽  
Cycle Progression ◽  
Vertebrate Limb ◽  
Damage Response

scholarly journals Wnt/beta-catenin signaling regulates vertebrate limb regeneration

2006 ◽  
Vol 20 (23) ◽  
pp. 3232-3237 ◽  
Author(s):  
Y. Kawakami ◽  
C. Rodriguez Esteban ◽  
M. Raya ◽  
H. Kawakami ◽  
M. Marti ◽  
...  
Keyword(s):  
Limb Regeneration ◽  
Beta Catenin ◽  
Vertebrate Limb

Vertebrate limb regeneration

Endeavour ◽  
1981 ◽  
Vol 5 (4) ◽  
pp. 177
Author(s):  
A.d'A Bellairs
Keyword(s):  
Limb Regeneration ◽  
Vertebrate Limb

scholarly journals Regulation of p53 is critical for vertebrate limb regeneration

2013 ◽  
Vol 110 (43) ◽  
pp. 17392-17397 ◽  
Author(s):  
M. H. Yun ◽  
P. B. Gates ◽  
J. P. Brockes
Keyword(s):  
Limb Regeneration ◽  
Vertebrate Limb

Isolation of potential vertebrate limb-identity genes

Development ◽  
1989 ◽  
Vol 105 (4) ◽  
pp. 813-820 ◽  
Author(s):  
C.J. Tabin
Keyword(s):  
Sequence Analysis ◽  
Differentially Express ◽  
Limb Regeneration ◽  
Differential Screening ◽  
Differentially Expressed ◽  
Vertebrate Limb ◽  
Differentially Express Genes ◽  
The Difference ◽  
Morphological Patterns ◽  
Mesodermal Tissue

Forelimbs and hindlimbs of tetrapods have different morphological patterns. One plausible explanation for the difference is that the cells that give rise to the limbs differentially express genes which control their pattern of development. Amphibian limb regeneration is an excellent system to test this hypothesis, since the same ultimate morphology is attained in regeneration as through embryogenesis. Using a combination of homeobox probes and differential screening, I have isolated two newt genes which are differentially expressed in regenerating forelimbs and hindlimbs. One of these genes displays properties expected of a gene involved in controlling limb morphology, including expression in mesodermal tissue and constancy of expression upon transplantation. Based on sequence analysis, this gene appears to be homologous to a homeobox-containing gene previously isolated from frog and human libraries.

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