scholarly journals Histone Lysine Demethylase Inhibitors

2016 ◽  
Vol 7 (1) ◽  
pp. a026484 ◽  
Author(s):  
Ashwini Jambhekar ◽  
Jamie N. Anastas ◽  
Yang Shi
Keyword(s):  
Histone Lysine ◽  
Histone Lysine Demethylase ◽  
Lysine Demethylase

scholarly journals Histone lysine demethylase 4B regulates general and unique gene expression signatures in hypoxic cancer cells

MedComm ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 414-429
Author(s):  
Lei Qiu ◽  
Yang Meng ◽  
Lingli Wang ◽  
Sumedha Gunewardena ◽  
Sicheng Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Cells ◽  
Unique Gene ◽  
Histone Lysine ◽  
Histone Lysine Demethylase ◽  
Gene Expression Signatures ◽  
Lysine Demethylase

scholarly journals A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay

2021 ◽  
Vol 2 (3) ◽  
pp. 100702
Author(s):  
Qiong Wu ◽  
Wenwei Lin ◽  
Zhen-Mei Li ◽  
Zoran Rankovic ◽  
Stephen W. White ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Histone Lysine ◽  
Histone Lysine Demethylase ◽  
Lysine Demethylase

scholarly journals The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96545 ◽  
Author(s):  
Kristine Williams ◽  
Jesper Christensen ◽  
Juri Rappsilber ◽  
Anders Lærke Nielsen ◽  
Jens Vilstrup Johansen ◽  
...  
Keyword(s):  
Dependent Manner ◽  
Histone Lysine ◽  
Histone Lysine Demethylase ◽  
Lysine Demethylase

scholarly journals Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A

2018 ◽  
Vol 61 (23) ◽  
pp. 10588-10601 ◽  
Author(s):  
John R. Horton ◽  
Clayton B. Woodcock ◽  
Qin Chen ◽  
Xu Liu ◽  
Xing Zhang ◽  
...  
Keyword(s):  
Irreversible Inhibitors ◽  
Histone Lysine ◽  
Histone Lysine Demethylase ◽  
Lysine Demethylase

scholarly journals A chemoprobe tracks its target

2019 ◽  
Vol 294 (20) ◽  
pp. 8323-8324
Author(s):  
Aseem Z. Ansari
Keyword(s):  
Small Molecule ◽  
Clinical Utility ◽  
Small Molecule Inhibitors ◽  
Indirect Measure ◽  
Histone Marks ◽  
Histone Lysine ◽  
Histone Lysine Demethylase ◽  
Histone Modifying Enzymes ◽  
Lysine Demethylase ◽  
In Cells

Small-molecule inhibitors of histone-modifying enzymes have significant clinical utility for managing diseases such as cancer. These inhibitors are usually identified and monitored through their effects on the gain or loss of specific histone marks. In cells, multiple related enzymes can place or remove a specific mark; therefore, relying on an indirect measure of inhibitor engagement can be misleading. Mascaró et al. describe a luminescence-based ELISA approach that directly monitors binding of inhibitors to the histone lysine demethylase KDM1A.

Histone lysine demethylase KDM5B maintains chronic myeloid leukemia via multiple epigenetic actions

2020 ◽  
Vol 82 ◽  
pp. 53-65 ◽  
Author(s):  
Shen Xue ◽  
Yuk Man Lam ◽  
Zhikai He ◽  
Yan Zheng ◽  
Lin Li ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Histone Lysine ◽  
Histone Lysine Demethylase ◽  
Lysine Demethylase

scholarly journals Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds

2016 ◽  
Vol 23 (7) ◽  
pp. 769-781 ◽  
Author(s):  
John R. Horton ◽  
Xu Liu ◽  
Molly Gale ◽  
Lizhen Wu ◽  
John R. Shanks ◽  
...  
Keyword(s):  
Structural Basis ◽  
Histone Lysine ◽  
Histone Lysine Demethylase ◽  
Lysine Demethylase

Advances in the development of histone lysine demethylase inhibitors

2015 ◽  
Vol 23 ◽  
pp. 52-60 ◽  
Author(s):  
Tamara Maes ◽  
Elena Carceller ◽  
Jordi Salas ◽  
Alberto Ortega ◽  
Carlos Buesa
Keyword(s):  
Histone Lysine ◽  
Histone Lysine Demethylase ◽  
Lysine Demethylase
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