scholarly journals NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)

2012 ◽  
Vol 4 (6) ◽  
pp. a005710-a005710 ◽  
Author(s):  
C. Luscher ◽  
R. C. Malenka
Keyword(s):  
Nmda Receptor ◽  
Long Term Potentiation ◽  
Long Term Depression ◽  
Term Potentiation

Calcium signals in long-term potentiation and long-term depression

1999 ◽  
Vol 77 (9) ◽  
pp. 722-734 ◽  
Author(s):  
John A Connor ◽  
Jeffrey Petrozzino ◽  
Lucas D Pozzo-Miller ◽  
Satoru Otani
Keyword(s):  
Nmda Receptor ◽  
Neuronal Plasticity ◽  
Hippocampal Neurons ◽  
Low Frequency ◽  
Long Term Potentiation ◽  
Long Term Depression ◽  
Metabotropic Receptor ◽  
Ca1 Neurons ◽  
Term Potentiation

We describe postsynaptic Ca2+ signals that subserve induction of two forms of neuronal plasticity, long-term potentiation (LTP) and long-term depression (LTD), in rat hippocampal neurons. The common induction protocol for LTP, a 1-s, 50-Hz tetanus, generates Ca2+ increases of about 50 µM in dendritic spines of CA1 neurons. These very large increases, measured using a low affinity indicator (Mg fura 5), were found only in the spines and tertiary dendrites, and were dependent upon influx through N-methyl-D-aspartate (NMDA) gated channels. High affinity Ca2+ indicators (e.g., fura 2) are unable to demonstrate these events. In acute slices, neighboring dendritic branches often showed very different responses to a tetanus, and in some instances, neighboring spines on the same dendrite responded differently. LTD in mature CA1 neurons was induced by a low frequency stimulus protocol (2 Hz, 900 pulses), in the presence of GABA- and NMDA-receptor blockers. This LTD protocol produced dendritic Ca2+ increases of <1 µM. Duration of the Ca2+ increase was ~30 s and was due to voltage-gated Ca2+ influx. Finally, the ability of synaptically addressed Ca2+ stores to release Ca2+ was studied in CA3 neurons and was found to require immediate preloading and high intensity presynaptic stimulation, conditions unlike normal LTP-LTD protocols.Key words: long-term potentiation, long-term depression, Ca2+, neuronal plasticity, fluorescence imaging, N-methyl-D-aspartate (NMDA) receptor, metabotropic receptor.

scholarly journals Distinct NMDA Receptor Subpopulations Contribute to Long-Term Potentiation and Long- Term Depression Induction

2000 ◽  
Vol 20 (12) ◽  
pp. RC81-RC81 ◽  
Author(s):  
Sabina Hrabetova ◽  
Peter Serrano ◽  
Nancy Blace ◽  
Heong W. Tse ◽  
Donald A. Skifter ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Long Term Potentiation ◽  
Long Term Depression ◽  
Term Potentiation

scholarly journals Defective place cell activity in nociceptin receptor knockout mice with elevated NMDA receptor-dependent long-term potentiation

2005 ◽  
Vol 565 (2) ◽  
pp. 579-591 ◽  
Author(s):  
Franco A. Taverna ◽  
John Georgiou ◽  
Robert J. McDonald ◽  
Nancy S. Hong ◽  
Alexander Kraev ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Knockout Mice ◽  
Cell Activity ◽  
Long Term Potentiation ◽  
Place Cell ◽  
Term Potentiation ◽  
Nociceptin Receptor
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