scholarly journals Diffusion MRI free water is a sensitive marker of age-related changes in the cingulum

2019 ◽  
Author(s):  
Manon Edde ◽  
Guillaume Theaud ◽  
François Rheault ◽  
Bixente Dilharreguy ◽  
Catherine Helmer ◽  
...  
Keyword(s):  
White Matter ◽  
Verbal Fluency ◽  
Diffusion Mri ◽  
White Matter Hyperintensities ◽  
Free Water ◽  
Partial Volume ◽  
Cingulum Bundle ◽  
Partial Volume Effects ◽  
Age Related ◽  
Water Elimination

AbstractDiffusion MRI is extensively used to investigate changes in white matter microstructure. However, diffusion measures within white matter tissue can be affected by partial volume effects due to cerebrospinal fluid and white matter hyperintensities, especially in the aging brain. In previous aging studies, the cingulum bundle that plays a central role in the architecture of the brain networks supporting cognitive functions has been associated with cognitive deficits. However, most of these studies did not consider the partial volume effects on diffusion measures. The aim of this study was to evaluate the effect of free water elimination on diffusion measures of the cingulum in a group of 68 healthy elderly individuals. We first determined the effect of free water elimination on conventional DTI measures and then examined the effect of free water elimination on verbal fluency performance over 12 years. The cingulum bundle was reconstructed with a tractography pipeline including a white matter hyperintensities mask to limit the negative impact of hyperintensities on fiber tracking algorithms. We observed that free water elimination improved the sensitivity of conventional DTI measures to detect associations between tissue-specific diffusion measures of the cingulum and changes in verbal fluency in older individuals. Moreover, free water content measured along the cingulum was independently strongly associated with changes in verbal fluency. These observations suggest the importance of using free water elimination when studying brain aging and indicate that free water itself could be a relevant marker for age-related cingulum white matter modifications and cognitive decline.

scholarly journals Free water: A marker of age-related modifications of the cingulum white matter and its association with cognitive decline

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242696
Author(s):  
Manon Edde ◽  
Guillaume Theaud ◽  
François Rheault ◽  
Bixente Dilharreguy ◽  
Catherine Helmer ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Verbal Fluency ◽  
White Matter Hyperintensities ◽  
Free Water ◽  
Partial Volume ◽  
Cingulum Bundle ◽  
Partial Volume Effects ◽  
Age Related ◽  
Water Elimination

Diffusion MRI is extensively used to investigate changes in white matter microstructure. However, diffusion measures within white matter tissue can be affected by partial volume effects due to cerebrospinal fluid and white matter hyperintensities, especially in the aging brain. In previous aging studies, the cingulum bundle that plays a central role in the architecture of the brain networks supporting cognitive functions has been associated with cognitive deficits. However, most of these studies did not consider the partial volume effects on diffusion measures. The aim of this study was to evaluate the effect of free water elimination on diffusion measures of the cingulum in a group of 68 healthy elderly individuals. We first determined the effect of free water elimination on conventional DTI measures and then examined the effect of free water elimination on verbal fluency performance over 12 years. The cingulum bundle was reconstructed with a tractography pipeline including a white matter hyperintensities mask to limit the negative impact of hyperintensities on fiber tracking algorithms. We observed that free water elimination increased the ability of conventional DTI measures to detect associations between tissue diffusion measures of the cingulum and changes in verbal fluency in older individuals. Moreover, free water content and mean diffusivity measured along the cingulum were independently associated with changes in verbal fluency. This suggests that both tissue modifications and an increase in interstitial isotropic water would contribute to cognitive decline. These observations reinforce the importance of using free water elimination when studying brain aging and indicate that free water itself could be a relevant marker for age-related cingulum white matter modifications and cognitive decline.

Characterizing Extracellular White Matter Pathologies Using Free Water Imaging Across the Schizophrenia Illness Course: A Multi-Site Harmonized Diffusion MRI Study

2021 ◽  
Vol 89 (9) ◽  
pp. S85
Author(s):  
Suheyla Cetin-Karayumak ◽  
Ofer Pasternak ◽  
Fan Zhang ◽  
Johanna Seitz ◽  
Doron Elad ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Mri ◽  
Free Water ◽  
Mri Study

scholarly journals Amyloid burden and white matter hyperintensities mediate age-related cognitive differences

2020 ◽  
Vol 86 ◽  
pp. 16-26 ◽  
Author(s):  
Pénélope Sévigny Dupont ◽  
Christian Bocti ◽  
Maude Joannette ◽  
Marie Maxime Lavallée ◽  
Jim Nikelski ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Amyloid Burden ◽  
Cognitive Differences ◽  
Age Related

scholarly journals White-matter free-water diffusion MRI in schizophrenia: a systematic review and meta-analysis

2022 ◽  
Author(s):  
Inês Carreira Figueiredo ◽  
Faith Borgan ◽  
Ofer Pasternak ◽  
Federico E. Turkheimer ◽  
Oliver D. Howes
Keyword(s):  
White Matter ◽  
Healthy Volunteers ◽  
Diffusion Mri ◽  
Clinical Symptoms ◽  
Free Water ◽  
Brain Regions ◽  
Water Levels ◽  
First Episode ◽  
Whole Brain ◽  
Illness Duration

AbstractWhite-matter abnormalities, including increases in extracellular free-water, are implicated in the pathophysiology of schizophrenia. Recent advances in diffusion magnetic resonance imaging (MRI) enable free-water levels to be indexed. However, the brain levels in patients with schizophrenia have not yet been systematically investigated. We aimed to meta-analyse white-matter free-water levels in patients with schizophrenia compared to healthy volunteers. We performed a literature search in EMBASE, MEDLINE, and PsycINFO databases. Diffusion MRI studies reporting free-water in patients with schizophrenia compared to healthy controls were included. We investigated the effect of demographic variables, illness duration, chlorpromazine equivalents of antipsychotic medication, type of scanner, and clinical symptoms severity on free-water measures. Ten studies, including five of first episode of psychosis have investigated free-water levels in schizophrenia, with significantly higher levels reported in whole-brain and specific brain regions (including corona radiata, internal capsule, superior and inferior longitudinal fasciculus, cingulum bundle, and corpus callosum). Six studies, including a total of 614 participants met the inclusion criteria for quantitative analysis. Whole-brain free-water levels were significantly higher in patients relative to healthy volunteers (Hedge’s g = 0.38, 95% confidence interval (CI) 0.07–0.69, p = 0.02). Sex moderated this effect, such that smaller effects were seen in samples with more females (z = −2.54, p < 0.05), but antipsychotic dose, illness duration and symptom severity did not. Patients with schizophrenia have increased free-water compared to healthy volunteers. Future studies are necessary to determine the pathological sources of increased free-water, and its relationship with illness duration and severity.

Development and validation of morphological segmentation of age-related cerebral white matter hyperintensities

NeuroImage ◽  
2009 ◽  
Vol 47 (1) ◽  
pp. 199-203 ◽  
Author(s):  
Richard Beare ◽  
Velandai Srikanth ◽  
Jian Chen ◽  
Thanh G. Phan ◽  
Jennifer Stapleton ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Cerebral White Matter ◽  
Morphological Segmentation ◽  
Age Related ◽  
Development And Validation

Visual Assessment of Age-Related White Matter Hyperintensities Using FLAIR Images at 3 T: Inter- and Intra-Rater Agreement

2015 ◽  
Vol 16 (3-4) ◽  
pp. 279-283 ◽  
Author(s):  
Claire Boutet ◽  
Laure Rouffiange-Leclair ◽  
Fabien Schneider ◽  
Jean-Philippe Camdessanché ◽  
Jean-Christophe Antoine ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Visual Assessment ◽  
Rater Agreement ◽  
Age Related

scholarly journals Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexander Rau ◽  
Marco Reisert ◽  
Elias Kellner ◽  
Jonas A. Hosp ◽  
Horst Urbach ◽  
...  
Keyword(s):  
White Matter ◽  
Water Content ◽  
Normal Pressure Hydrocephalus ◽  
Interstitial Fluid ◽  
White Matter Hyperintensities ◽  
Free Water ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Imaging Features ◽  
Deep White Matter

AbstractPeriventricular white matter changes are common in patients with idiopathic normal pressure hydrocephalus (iNPH) and considered to represent focally elevated interstitial fluid. We compared diffusion measures in periventricular hyperintensities in patients with imaging features of iNPH to patients without. The hypothesis is that periventricular hyperintensities in patients with presumed iNPH show higher water content than in patients without imaging features of iNPH. 21 patients with iNPH Radscale 7–12 (“high probability of iNPH”) and 10 patients with iNPH Radscale 2–4 (“low probability of iNPH”) were examined with a neurodegeneration imaging protocol including a diffusion microstructure imaging sequence. Periventricular hyperintensities and deep white matter hyperintensities were segmented and diffusion measures were compared. In patients with imaging features of iNPH, the free water content in periventricular hyperintensities was significantly higher compared to the control group (p = 0.005). This effect was also detectable in deep white matter hyperintensities (p = 0.024). Total brain volumes and total gray or white matter volumes did not differ between the groups. Periventricular cap free water fraction was highly discriminative regarding patients with presumed iNPH and controls with an ROC AUC of 0.933. Quantitative diffusion microstructure imaging shows elevated water content in periventricular hyperintensities in patients with imaging features of iNPH, which could be the imaging correlate for pathologic fluid accumulation and may be used as an imaging biomarker in the future.

P.0757 White-matter free-water diffusion MRI in schizophrenia: a systematic review and meta-analysis

2021 ◽  
Vol 53 ◽  
pp. S551-S552
Author(s):  
I. Carreira Figueiredo ◽  
F. Borgan ◽  
O. Pasternak ◽  
F.E. Turkheimer ◽  
O. Howes
Keyword(s):  
Systematic Review ◽  
White Matter ◽  
Diffusion Mri ◽  
Meta Analysis ◽  
Free Water ◽  
Water Diffusion
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