scholarly journals Designing combination therapies using multiple optimal controls

2019 ◽  
Author(s):  
Jesse A Sharp ◽  
Alexander P Browning ◽  
Tarunendu Mapder ◽  
Christopher M Baker ◽  
Kevin Burrage ◽  
...  
Keyword(s):  
Optimal Strategies ◽  
Biological Species ◽  
Optimal Controls ◽  
Control Parameters ◽  
Combination Therapies ◽  
Multiple Control ◽  
Research Areas ◽  
Practical Guidance ◽  
Multiple Treatments ◽  
And Control

AbstractStrategic management of populations of interacting biological species routinely requires interventions combining multiple treatments or therapies. This is important in key research areas such as ecology, epidemiology, wound healing and oncology. Despite the well developed theory and techniques for determining single optimal controls, there is limited practical guidance supporting implementation of combination therapies. In this work we use optimal control theory to calculate optimal strategies for applying combination therapies to a model of acute myeloid leukaemia. We consider various combinations of continuous and bang-bang (discrete) controls, and we investigate how the control dynamics interact and respond to changes in the weighting and form of the pay-off characterising optimality. We demonstrate that the optimal controls respond non-linearly to treatment strength and control parameters, due to the interactions between species. We discuss challenges in appropriately characterising optimality in a multiple control setting and provide practical guidance for applying multiple optimal controls. Code used in this work to implement multiple optimal controls is available on GitHub.

A Rapid Recursive Experimental Approach to Structure/Control Re-Design

1995 ◽  
Author(s):  
Anton Pil ◽  
Haruhiko Asada
Keyword(s):  
System Performance ◽  
Recursive Algorithm ◽  
Descent Method ◽  
Gradient Descent Method ◽  
Control Parameters ◽  
Multiple Control ◽  
Mechatronic Systems ◽  
Loop Control ◽  
Structural Reinforcement ◽  
And Control

Abstract This paper introduces an experimental recursive method for simultaneously changing both the mechanical structure and control design of mechatronic systems in order to improve the system’s overall performance. The method improves a system’s closed-loop control specifications through recursive concurrent structure reinforcement and control gain optimization. By using a process of structural reinforcement, a single prototype structure can be used repeatedly until the system performance goals are achieved. To determine the optimal incremental structure changes, a recursive algorithm based on a gradient descent method and a parameter estimation theory is employed. After the incremental structure reinforcements are applied, the control parameters are optimized with respect to multiple control specifications. Next, the resulting system incorporating the structure and control changes is tested and compared with the desired level of performance. The entire process consisting of experimental evaluation, data analysis, and structure reinforcement is repeated until the system performance achieves the desired level. Simulation experiments are successful in changing both the structural and control parameters of a simplified positioning system and show improvement in the system’s overall settling time.

Probability model for control parameters in the aircraft's information and control systems

2018 ◽  
Vol 2 ◽  
pp. 9-16
Author(s):  
A. Al-Ammouri ◽  
◽  
H.A. Al-Ammori ◽  
A.E. Klochan ◽  
A.M. Al-Akhmad ◽  
...  
Keyword(s):  
Control Systems ◽  
Probability Model ◽  
Control Parameters ◽  
And Control

scholarly journals Resonance Instability of Photovoltaic E-Bike Charging Stations: Control Parameters Analysis, Modeling and Experiment

2019 ◽  
Vol 9 (2) ◽  
pp. 252 ◽  
Author(s):  
Ziqian Zhang ◽  
Cihan Gercek ◽  
Herwig Renner ◽  
Angèle Reinders ◽  
Lothar Fickert
Keyword(s):  
Major Effect ◽  
Current Control ◽  
Current Loop ◽  
Control Methods ◽  
Control Parameters ◽  
Charging System ◽  
Grid Connected Inverter ◽  
The Time Domain ◽  
Charging Stations ◽  
And Control

This article presents an in-situ comparative analysis and power quality tests of a newly developed photovoltaic charging system for e-bikes. The various control methods of the inverter are modeled and a single-phase grid-connected inverter is tested under different conditions. Models are constituted for two current control methods; the proportional resonance and the synchronous rotating frames. In order to determine the influence of the control parameters, the system is analyzed analytically in the time domain as well as in the frequency domain by simulation. The tests indicated the resonance instability of the photovoltaic inverter. The passivity impedance-based stability criterion is applied in order to analyze the phenomenon of resonance instability. In conclusion, the phase-locked loop (PLL) bandwidth and control parameters of the current loop have a major effect on the output admittance of the inverter, which should be adjusted to make the system stable.

Hybrid genetic algorithm-based optimization of powertrain and control parameters of plug-in hybrid electric bus

2015 ◽  
Vol 352 (3) ◽  
pp. 776-801 ◽  
Author(s):  
Liang Li ◽  
Yahui Zhang ◽  
Chao Yang ◽  
Xiaohong Jiao ◽  
Lipeng Zhang ◽  
...  
Keyword(s):  
Genetic Algorithm ◽  
Hybrid Genetic Algorithm ◽  
Control Parameters ◽  
Hybrid Electric Bus ◽  
Electric Bus ◽  
Hybrid Electric ◽  
And Control

scholarly journals Energetic flexibility on wastewater treatment plants

2017 ◽  
Vol 76 (5) ◽  
pp. 1225-1233 ◽  
Author(s):  
M. Schäfer ◽  
I. Hobus ◽  
T. G. Schmitt
Keyword(s):  
Wastewater Treatment ◽  
Wastewater Treatment Plants ◽  
Energy Systems ◽  
Energy Market ◽  
Control Parameters ◽  
Effluent Quality ◽  
The Future ◽  
Energy Consuming ◽  
Characteristic Values ◽  
And Control

In the future, an additional potential of control reserve as well as storage capacities will be required to compensate fluctuating renewable energy availability. The operation of energy systems will change and flexibility in energy generation and consumption will rise to a valuable asset. Wastewater treatment plants (WWTPs) are capable of providing the flexibility needed, not only with their energy generators but also in terms of their energy consuming aggregates on the plant. To meet challenges of the future in regard to energy purchase and to participate in and contribute to such a volatile energy market, WWTPs have to reveal their energetic potential as a flexible service provider. Based on the evaluated literature and a detailed analysis of aggregates on a pilot WWTP an aggregate management has been developed to shift loads and provide a procedure to identify usable aggregates, characteristic values and control parameters to ensure effluent quality. The results show that WWTPs have a significant potential to provide energetic flexibility. Even for vulnerable components such as aeration systems, load-shifting is possible with appropriate control parameters and reasonable time slots without endangering system functionality.

Neurotechnology as a factor of the educational process transformation

2021 ◽  
pp. 98-13
Author(s):  
Л.Д. Александрова ◽  
Р.А. Богачева ◽  
Т.А. Чекалина ◽  
М.В. Максимова ◽  
В.И. Тимонина
Keyword(s):  
Effective Means ◽  
Individual Characteristics ◽  
Educational Process ◽  
Special Equipment ◽  
Research Areas ◽  
Long Time ◽  
Mental Abilities ◽  
The Individual ◽  
And Control

Изучение возможностей мозга для повышения качества обучения находится в центре внимания педагогической науки уже много лет. Развитие цифровизации позволило использовать в исследованиях специальное оборудование, с помощью которого можно оценивать и контролировать работу мозга, развивать умственные способности, познавательные функции и т. п. Нейротехнологии стали эффективным средством, позволяющим трансформировать образовательный процесс за счет подбора специального учебного контента с учетом индивидуальных особенностей обучающихся. Вместе с тем возникает необходимость в конкретизации терминологии и определении актуальных направлений исследований в данной области. For a long time, the study of the brain capabilities for the improvement of the quality of education has been an urgent direction in pedagogical science. Due to the development of digitalization, new areas of research have emerged related to the use of special equipment that makes it possible to assess and control brainwork, develop mental abilities, cognitive functions, etc. One of them is neurotechnology, which is an effective means of transforming the educational process: it offers educational content based on the individual characteristics of students. Thus, a need to concretize the terminology and determine the current research areas arises. The article aims to attempt to fill this gap with the help of a representative analysis of publications on neurotechnologies, as well as the essence of neuroeducation.

scholarly journals Influence of building design and control parameters on the potential of mixed-mode buildings in India

2019 ◽  
Vol 148 ◽  
pp. 157-172 ◽  
Author(s):  
Sriraj Gokarakonda ◽  
Christoph van Treeck ◽  
Rajan Rawal
Keyword(s):  
Mixed Mode ◽  
Building Design ◽  
Control Parameters ◽  
And Control
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