scholarly journals SOLQC : Synthetic Oligo Library Quality Control Tool

2019 ◽  
Author(s):  
Omer Sabary ◽  
Yoav Orlev ◽  
Roy Shafir ◽  
Leon Anavy ◽  
Eitan Yaakobi ◽  
...  

AbstractMotivationRecent years have seen a growing number and a broadening scope of studies using synthetic oligo libraries for a range of applications in synthetic biology. As experiments are growing by numbers and complexity, analysis tools can facilitate quality control and help in assessment and inference.ResultsWe present a novel analysis tool, called SOLQC, which enables fast and comprehensive analysis of synthetic oligo libraries, based on NGS analysis performed by the user. SOLQC provides statistical information such as the distribution of variant representation, different error rates and their dependence on sequence or library properties. SOLQC produces graphical descriptions of the analysis results. The results are reported in a flexible report format. We demonstrate SOLQC by analyzing literature libraries. We also discuss the potential benefits and relevance of the different components of the analysis.Availabilityhttps://app.gitbook.com/@yoav-orlev/s/solqc/

Author(s):  
Omer Sabary ◽  
Yoav Orlev ◽  
Roy Shafir ◽  
Leon Anavy ◽  
Eitan Yaakobi ◽  
...  

Abstract Motivation Recent years have seen a growing number and an expanding scope of studies using synthetic oligo libraries for a range of applications in synthetic biology. As experiments are growing by numbers and complexity, analysis tools can facilitate quality control and support better assessment and inference. Results We present a novel analysis tool, called SOLQC, which enables fast and comprehensive analysis of synthetic oligo libraries, based on NGS analysis performed by the user. SOLQC provides statistical information such as the distribution of variant representation, different error rates and their dependence on sequence or library properties. SOLQC produces graphical reports from the analysis, in a flexible format. We demonstrate SOLQC by analyzing literature libraries. We also discuss the potential benefits and relevance of the different components of the analysis. Availability and implementation SOLQC is a free software for non-commercial use, available at https://app.gitbook.com/@yoav-orlev/s/solqc/. For commercial use please contact the authors. Supplementary information Supplementary data are available at Bioinformatics online.


2021 ◽  
Author(s):  
Carmen Seller Oria ◽  
Adrian Thummerer ◽  
Jeffrey Free ◽  
Johannes A. Langendijk ◽  
Stefan Both ◽  
...  

2016 ◽  
Vol 145 (3) ◽  
pp. 308-315 ◽  
Author(s):  
Patrick C. Mathias ◽  
Emily H. Turner ◽  
Sheena M. Scroggins ◽  
Stephen J. Salipante ◽  
Noah G. Hoffman ◽  
...  

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Suharto Suharto ◽  

Abstract This study aims to determine and identify the causes of defects in the production process of PT. Triteguh Manunggal Sejati and know the level of sigma level. This research uses the six sigma method with the DMAIC approach as a quality control tool, which includes the Define, Measure, Analyze, Improve and Control stages. Based on this study the results obtained are the level of sigma level at PT.Triteguh Manunggal Sejati is 4.96, which means that in the stage of sigma level the company has not reached the level of six sigma levels because in the production process at PT.Triteguh Manunggal Sejati still has product defects in the production process not yet achieved zero defect. The causes of product defects are based on cause and effect diagrams namely lid / seal defects are leaky lid, broken lid, and tilted lid. Kata kunci : Defect, Six Sigma, DMAIC, cause and effect diagram


2021 ◽  
Author(s):  
Yijiang Chen ◽  
Jarcy Zee ◽  
Abigail Smith ◽  
Catherine Jayapandian ◽  
Jeffrey Hodgin ◽  
...  

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