scholarly journals Hyperactive/impulsive and inattention symptoms are associated with reduced ERP activity during different reward processing stages: Evidence from the electrophysiological Monetary Incentive Delay Task in adult ADHD

2019 ◽  
Author(s):  
M. P. Bennett ◽  
H. Kiiski ◽  
Z. Cao ◽  
F. R. Farina ◽  
R. Knight ◽  
...  
Keyword(s):  
Visual Cues ◽  
Adult Adhd ◽  
Monetary Incentive ◽  
Reward Processing ◽  
Button Press ◽  
Adhd Symptoms ◽  
Symptom Dimensions ◽  
Delay Task ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay

AbstractHyperactivity/impulsivity and inattention are core symptoms dimensions in attention-deficit/hyperactivity disorder. Some approaches suggest that these symptoms arise from deficits in the ability to anticipate and process rewards. However, evidence is equivocal with regard to ADHD-related differences in brain activity during reward processing. The aim of this study was to investigate when, and how, reward-related ERP activity was associated with hyperactive/impulsive symptoms and inattention symptoms. Adults with ADHD (n=34) and matched comparison participants (n=36) completed an electrophysiological version of the Monetary Incentive Delay task. This task separates reward processing into two stages-namely, an anticipation stage and a delivery stage. During the anticipation stage, visual cues signalled a possible monetary incentive (i.e. a reward or loss). After a brief delay, the delivery stage began, and incentives were delivered contingent on a speeded button-press. Electroencephalogram activity was simultaneously sampled and incentive-related event relate potentials (ERPs) calculated. These data were then analysed by calculating multiple regression models, at each sample point, wherein the correlation between incentive-related ERPs and ADHD symptoms was estimated. Linear and curvilinear associations between ERP activity and ADHD symptoms were tested in each regression mode. Findings suggest that ADHD symptoms were associated ERP activity at different reward processing stages. Hyperactive/impulsive symptoms were associated with reduced ERP activity during the initial anticipation of rewards from 224-329 ms post-reward cue. Inattention symptoms were associated with reduced ERP activity during the initial delivery of rewards from 251-280 ms post-reward onset. Finally, extreme ends of hyperactive/impulsive and inattention symptoms were associated with reduced ERP activity towards the end of the anticipation stage from 500 ms post-reward cue onwards. These results support the idea that reward processing is disrupted in ADHD while also shedding new light on the dynamic relationship between ADHD symptom dimensions and the neurological mechanisms of reward processing.

scholarly journals Der Effekt von Belohnungen auf die intraindividuelle Variabilität der Reaktionszeit bei erwachsenen ADHS-Patienten : eine Analyse anhand des Ex-Gauß’schen Verteilungsmodells

2021 ◽  
Author(s):  
◽  
Vera Christine Deppert
Keyword(s):  
Reaction Time ◽  
Adult Adhd ◽  
Monetary Incentive ◽  
Time Variability ◽  
Healthy Controls ◽  
Adhd Symptoms ◽  
Reaction Time Variability ◽  
Delay Task ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay

Increased intraindividual variability of reaction time is a main cognitive feature of Attention Deficit Hyperactivity Disorder. It is associated with deficits in sustained attention. While traditionally, mean and variance were used to characterize reaction time distributions, the ex-gaussian distributional model allows a more sophisticated analysis of reaction time series. Reaction time distributions are separated in a normal and an exponential component. The present study investigates the impact of incentives on reaction time variability in a sample of adult ADHD patients. ADHD is associated with increased Tau, the output parameter of the ex-gaussian model characterizing the exponential part of the distribution. Tau is linked to “lapses of attention”, which are more frequent in ADHD patients. It is known that tau can be modulated in ADHD Patients. It was therefore postulated that tau would be higher in ADHD Patients in a paradigm where quick answers were required but could be modulated by monetary incentives. In addition, the effect of “delay discounting”, which is more distinct in ADHD patients, on reaction time variability was investigated. Eventually, the association of variability measures with strength of ADHD symptoms was tested. To this end, reaction time distributions of 62 adult ADHD patients and 45 healthy controls from two different reaction time paradigms were analyzed. The monetary incentive delay task, by comprehending a control – and a win condition, allows an investigation of the effect of incentives on reaction times. Subjects had to react as fast as possible by keypress to a stimulus, after a cue signaled a possible monetary reward. During the Delay-Discounting-Task, subjects had to choose between sooner, but smaller, and higher delayed monetary rewards, during which they could use as much time for consideration as desired. Results show that an increased Tau in the control condition of the monetary- incentive-delay-task could be replicated, while a distinct influence of the win condition emerged. Subjects with ADHD showed an improvement of Tau in the win condition even below the level of healthy controls. However, they showed increased variability of the “regular” responses around the mean of the normal component of the distribution, represented by sigma. Moreover, it was indicated by trend a higher reaction time variability in ADHD patients during choices of delayed rewards. Tau was associated the current symptom strength as well as with the strength of ADHD-Symptoms during childhood, assessed by questionnaire. While the present results could have implications for etiological models of the disease, they may also contribute to the development of novel diagnostic methods. In advanced studies, neural correlates of sophisticated measures of reaction time variability should be investigated. Furthermore, they should be associated with genetic risk factors with regard to possible endophenotypes. Possible implications for clinical handling of patients should be explored.

Reward Processing in Late Life Depression: Insights From the Monetary Incentive Delay Task

2021 ◽  
Vol 89 (9) ◽  
pp. S303-S304
Author(s):  
Jack Kaufman ◽  
Joseph Kim ◽  
Anna Bradford ◽  
Jacob Germain ◽  
Victor Patron ◽  
...  
Keyword(s):  
Late Life ◽  
Monetary Incentive ◽  
Reward Processing ◽  
Late Life Depression ◽  
Delay Task ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay

scholarly journals The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers

2020 ◽  
Vol 34 (9) ◽  
pp. 969-980 ◽  
Author(s):  
Will Lawn ◽  
James Hill ◽  
Chandni Hindocha ◽  
Jocelyn Yim ◽  
Yumeya Yamamori ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Brain Activity ◽  
Neural Correlates ◽  
Monetary Incentive ◽  
Reward Processing ◽  
Delay Task ◽  
Reward Anticipation ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay ◽  
Healthy Participants

Background: Cannabidiol has potential therapeutic benefits for people with psychiatric disorders characterised by reward function impairment. There is existing evidence that cannabidiol may influence some aspects of reward processing. However, it is unknown whether cannabidiol acutely affects brain function underpinning reward anticipation and feedback. Hypotheses: We predicted that cannabidiol would augment brain activity associated with reward anticipation and feedback. Methods: We administered a single 600 mg oral dose of cannabidiol and matched placebo to 23 healthy participants in a double-blind, placebo-controlled, repeated-measures design. We employed the monetary incentive delay task during functional magnetic resonance imaging to assay the neural correlates of reward anticipation and feedback. We conducted whole brain analyses and region-of-interest analyses in pre-specified reward-related brain regions. Results: The monetary incentive delay task elicited expected brain activity during reward anticipation and feedback, including in the insula, caudate, nucleus accumbens, anterior cingulate and orbitofrontal cortex. However, across the whole brain, we did not find any evidence that cannabidiol altered reward-related brain activity. Moreover, our Bayesian analyses showed that activity in our regions-of-interest was similar following cannabidiol and placebo. Additionally, our behavioural measures of motivation for reward did not show a significant difference between cannabidiol and placebo. Discussion: Cannabidiol did not acutely affect the neural correlates of reward anticipation and feedback in healthy participants. Future research should explore the effects of cannabidiol on different components of reward processing, employ different doses and administration regimens, and test its reward-related effects in people with psychiatric disorders.

F88. A Transdiagnostic Study of Reward Processing Alterations in Adolescents Using the Monetary Incentive Delay Task

2018 ◽  
Vol 83 (9) ◽  
pp. S271-S272
Author(s):  
Kiana Khosravian ◽  
Hanna Keren ◽  
Liana Meffert ◽  
Daniel S. Pine ◽  
Argyris Stringaris
Keyword(s):  
Monetary Incentive ◽  
Reward Processing ◽  
Delay Task ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay

scholarly journals The effects of age on reward magnitude processing in the monetary incentive delay task

NeuroImage ◽  
2020 ◽  
Vol 207 ◽  
pp. 116368 ◽  
Author(s):  
Isha Dhingra ◽  
Sheng Zhang ◽  
Simon Zhornitsky ◽  
Thang M. Le ◽  
Wuyi Wang ◽  
...  
Keyword(s):  
Reward Magnitude ◽  
Monetary Incentive ◽  
Magnitude Processing ◽  
Delay Task ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay

Adolescents are driven by incentive valence, not magnitude, on the monetary incentive delay task

2015 ◽  
Vol 146 ◽  
pp. e151
Author(s):  
Jane Joseph ◽  
X. Zhu ◽  
C. Benca ◽  
G. Baik ◽  
F. Davies ◽  
...  
Keyword(s):  
Monetary Incentive ◽  
Delay Task ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay

scholarly journals Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task

2016 ◽  
Vol 22 (6) ◽  
pp. 1576-1589 ◽  
Author(s):  
Liam J Nestor ◽  
Anna Murphy ◽  
John McGonigle ◽  
Csaba Orban ◽  
Laurence Reed ◽  
...  
Keyword(s):  
Monetary Incentive ◽  
Delay Task ◽  
Monetary Incentive Delay Task ◽  
Monetary Incentive Delay
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