scholarly journals Detecting prodromal Alzheimer’s disease with MRI through deep learning

2019 ◽  
Author(s):  
Xinyang Feng ◽  
Frank A. Provenzano ◽  
Scott A. Small ◽  
Keyword(s):  
Deep Learning ◽  
Large Scale ◽  
Data Augmentation ◽  
Hippocampal Formation ◽  
Mechanistic Explanation ◽  
Learning Model ◽  
Tau Pathology ◽  
Cross Sectional ◽  
And Performance ◽  
Deep Learning Model

ABSTRACTDeep learning applied to MRI for Alzheimer’s classification is hypothesized to improve if the deep learning model implicates disease’s pathophysiology. The challenge in testing this hypothesis is that large-scale data are required to train this type of model. Here, we overcome this challenge by using a novel data augmentation strategy and show that our MRI-based deep learning model classifies Alzheimer’s dementia with high accuracy. Moreover, a class activation map was found dominated by signal from the hippocampal formation, a site where Alzheimer’s pathophysiology begins. Next, we tested the model’s performance in prodromal Alzheimer’s when patients present with mild cognitive impairment (MCI). We retroactively dichotomized a large cohort of MCI patients who were followed for up to 10 years into those with and without prodromal Alzheimer’s at baseline and used the dementia-derived model to generate individual ‘deep learning MRI’ scores. We compared the two groups on these scores, and on other biomarkers of amyloid pathology, tau pathology, and neurodegeneration. The deep learning MRI scores outperformed nearly all other biomarkers, including—unexpectedly—biomarkers of amyloid or tau pathology, in classifying prodromal disease and in predicting clinical progression. Providing a mechanistic explanation, the deep learning MRI scores were found to be linked to regional tau pathology, through investigations using cross-sectional, longitudinal, premortem and postmortem data. Our findings validate that a disease’s known pathophysiology can improve the design and performance of deep learning models. Moreover, by showing that deep learning can extract useful biomarker information from conventional MRIs, the advantages of this model extend practically, potentially reducing patient burden, risk, and cost.

scholarly journals Variable generalization performance of a deep learning model to detect pneumonia in chest radiographs: A cross-sectional study

PLoS Medicine ◽  
2018 ◽  
Vol 15 (11) ◽  
pp. e1002683 ◽  
Author(s):  
John R. Zech ◽  
Marcus A. Badgeley ◽  
Manway Liu ◽  
Anthony B. Costa ◽  
Joseph J. Titano ◽  
...  
Keyword(s):  
Deep Learning ◽  
Learning Model ◽  
Cross Sectional Study ◽  
Chest Radiographs ◽  
Sectional Study ◽  
Cross Sectional ◽  
Generalization Performance ◽  
Deep Learning Model

scholarly journals Microwave Dielectric Property Retrieval from Open-Ended Coaxial Probe Response with Deep Learning

2021 ◽  
Author(s):  
Cemanur Aydinalp ◽  
Sulayman Joof ◽  
Mehmet Nuri Akinci ◽  
Ibrahim Akduman ◽  
Tuba Yilmaz
Keyword(s):  
Deep Learning ◽  
Dielectric Property ◽  
Large Scale ◽  
Real Data ◽  
Learning Model ◽  
Data Generation ◽  
Retrieval Technique ◽  
Design Flexibility ◽  
A New Technique ◽  
Deep Learning Model

In the manuscript, we propose a new technique for determination of Debye parameters, representing the dielectric properties of materials, from the reflection coefficient response of open-ended coaxial probes. The method retrieves the Debye parameters using a deep learning model designed through utilization of numerically generated data. Unlike real data, using synthetically generated input and output data for training purposes provides representation of a wide variety of materials with rapid data generation. Furthermore, the proposed method provides design flexibility and can be applied to any desired probe with intended dimensions and material. Next, we experimentally verified the designed deep learning model using measured reflection coefficients when the probe was terminated with five different standard liquids, four mixtures,and a gel-like material.and compared the results with the literature. Obtained mean percent relative error was ranging from 1.21±0.06 to 10.89±0.08. Our work also presents a large-scale statistical verification of the proposed dielectric property retrieval technique.

scholarly journals A Physics-Infused Deep Learning Model for the Prediction of Refractive Indices and Its Use for the Large-Scale Screening of Organic Compound Space

2019 ◽  
Author(s):  
Mojtaba Haghighatlari ◽  
Gaurav Vishwakarma ◽  
Mohammad Atif Faiz Afzal ◽  
Johannes Hachmann
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Large Scale ◽  
Organic Molecules ◽  
Learning Model ◽  
Training Data ◽  
Refractive Indices ◽  
Learning Models ◽  
Deep Learning Model ◽  
Machine Learning Models

<div><div><div><p>We present a multitask, physics-infused deep learning model to accurately and efficiently predict refractive indices (RIs) of organic molecules, and we apply it to a library of 1.5 million compounds. We show that it outperforms earlier machine learning models by a significant margin, and that incorporating known physics into data-derived models provides valuable guardrails. Using a transfer learning approach, we augment the model to reproduce results consistent with higher-level computational chemistry training data, but with a considerably reduced number of corresponding calculations. Prediction errors of machine learning models are typically smallest for commonly observed target property values, consistent with the distribution of the training data. However, since our goal is to identify candidates with unusually large RI values, we propose a strategy to boost the performance of our model in the remoter areas of the RI distribution: We bias the model with respect to the under-represented classes of molecules that have values in the high-RI regime. By adopting a metric popular in web search engines, we evaluate our effectiveness in ranking top candidates. We confirm that the models developed in this study can reliably predict the RIs of the top 1,000 compounds, and are thus able to capture their ranking. We believe that this is the first study to develop a data-derived model that ensures the reliability of RI predictions by model augmentation in the extrapolation region on such a large scale. These results underscore the tremendous potential of machine learning in facilitating molecular (hyper)screening approaches on a massive scale and in accelerating the discovery of new compounds and materials, such as organic molecules with high-RI for applications in opto-electronics.</p></div></div></div>

scholarly journals Spatio-temporal deep learning model for distortion classification in laparoscopic video

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 1010
Author(s):  
Nouar AlDahoul ◽  
Hezerul Abdul Karim ◽  
Abdulaziz Saleh Ba Wazir ◽  
Myles Joshua Toledo Tan ◽  
Mohammad Faizal Ahmad Fauzi
Keyword(s):  
Deep Learning ◽  
Large Scale ◽  
Spatial Information ◽  
Short Term Memory ◽  
Learning Model ◽  
Motion Blur ◽  
Video Frame ◽  
Video Enhancement ◽  
Deep Learning Model ◽  
Laparoscopic Videos

Background: Laparoscopy is a surgery performed in the abdomen without making large incisions in the skin and with the aid of a video camera, resulting in laparoscopic videos. The laparoscopic video is prone to various distortions such as noise, smoke, uneven illumination, defocus blur, and motion blur. One of the main components in the feedback loop of video enhancement systems is distortion identification, which automatically classifies the distortions affecting the videos and selects the video enhancement algorithm accordingly. This paper aims to address the laparoscopic video distortion identification problem by developing fast and accurate multi-label distortion classification using a deep learning model. Current deep learning solutions based on convolutional neural networks (CNNs) can address laparoscopic video distortion classification, but they learn only spatial information. Methods: In this paper, utilization of both spatial and temporal features in a CNN-long short-term memory (CNN-LSTM) model is proposed as a novel solution to enhance the classification. First, pre-trained ResNet50 CNN was used to extract spatial features from each video frame by transferring representation from large-scale natural images to laparoscopic images. Next, LSTM was utilized to consider the temporal relation between the features extracted from the laparoscopic video frames to produce multi-label categories. A novel laparoscopic video dataset proposed in the ICIP2020 challenge was used for training and evaluation of the proposed method. Results: The experiments conducted show that the proposed CNN-LSTM outperforms the existing solutions in terms of accuracy (85%), and F1-score (94.2%). Additionally, the proposed distortion identification model is able to run in real-time with low inference time (0.15 sec). Conclusions: The proposed CNN-LSTM model is a feasible solution to be utilized in laparoscopic videos for distortion identification.

scholarly journals Simultaneous Hand Gesture Classification and Finger Angle Estimation via a Novel Dual-Output Deep Learning Model

Sensors ◽  
2020 ◽  
Vol 20 (10) ◽  
pp. 2972
Author(s):  
Qinghua Gao ◽  
Shuo Jiang ◽  
Peter B. Shull
Keyword(s):  
Deep Learning ◽  
Human Computer Interaction ◽  
Data Augmentation ◽  
Experimental Testing ◽  
Learning Model ◽  
Hand Gesture ◽  
Angle Estimation ◽  
Gesture Classification ◽  
Deep Learning Model ◽  
Computer Interaction

Hand gesture classification and finger angle estimation are both critical for intuitive human–computer interaction. However, most approaches study them in isolation. We thus propose a dual-output deep learning model to enable simultaneous hand gesture classification and finger angle estimation. Data augmentation and deep learning were used to detect spatial-temporal features via a wristband with ten modified barometric sensors. Ten subjects performed experimental testing by flexing/extending each finger at the metacarpophalangeal joint while the proposed model was used to classify each hand gesture and estimate continuous finger angles simultaneously. A data glove was worn to record ground-truth finger angles. Overall hand gesture classification accuracy was 97.5% and finger angle estimation R 2 was 0.922, both of which were significantly higher than shallow existing learning approaches used in isolation. The proposed method could be used in applications related to the human–computer interaction and in control environments with both discrete and continuous variables.

scholarly journals Hierarchical Graph Transformer-Based Deep Learning Model for Large-Scale Multi-Label Text Classification

IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 30885-30896 ◽  
Author(s):  
Jibing Gong ◽  
Hongyuan Ma ◽  
Zhiyong Teng ◽  
Qi Teng ◽  
Hekai Zhang ◽  
...  
Keyword(s):  
Deep Learning ◽  
Text Classification ◽  
Large Scale ◽  
Learning Model ◽  
Hierarchical Graph ◽  
Deep Learning Model

scholarly journals A Joint Deep Learning Model for Simultaneous Batch Effect Correction, Denoising and Clustering in Single-Cell Transcriptomics

2020 ◽  
Author(s):  
Justin Lakkis ◽  
David Wang ◽  
Yuanchao Zhang ◽  
Gang Hu ◽  
Kui Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Deep Learning ◽  
Single Cell ◽  
Large Scale ◽  
Nearest Neighbor ◽  
Learning Model ◽  
Batch Effect ◽  
Marker Genes ◽  
Deep Learning Model ◽  
Variable Genes

AbstractRecent development of single-cell RNA-seq (scRNA-seq) technologies has led to enormous biological discoveries. As the scale of scRNA-seq studies increases, a major challenge in analysis is batch effect, which is inevitable in studies involving human tissues. Most existing methods remove batch effect in a low-dimensional embedding space. Although useful for clustering, batch effect is still present in the gene expression space, leaving downstream gene-level analysis susceptible to batch effect. Recent studies have shown that batch effect correction in the gene expression space is much harder than in the embedding space. Popular methods such as Seurat3.0 rely on the mutual nearest neighbor (MNN) approach to remove batch effect in the gene expression space, but MNN can only analyze two batches at a time and it becomes computationally infeasible when the number of batches is large. Here we present CarDEC, a joint deep learning model that simultaneously clusters and denoises scRNA-seq data, while correcting batch effect both in the embedding and the gene expression space. Comprehensive evaluations spanning different species and tissues showed that CarDEC consistently outperforms scVI, DCA, and MNN. With CarDEC denoising, those non-highly variable genes offer as much signal for clustering as the highly variable genes, suggesting that CarDEC substantially boosted information content in scRNA-seq. We also showed that trajectory analysis using CarDEC’s denoised and batch corrected expression as input revealed marker genes and transcription factors that are otherwise obscured in the presence of batch effect. CarDEC is computationally fast, making it a desirable tool for large-scale scRNA-seq studies.

scholarly journals A New Deep Learning Model for Fault Diagnosis with Good Anti-Noise and Domain Adaptation Ability on Raw Vibration Signal

2017 ◽  
Author(s):  
Wei Zhang ◽  
Gaoliang Peng ◽  
Chuanhao Li ◽  
Yuanhang Chen ◽  
Zhujun Zhang
Keyword(s):  
Deep Learning ◽  
Fault Diagnosis ◽  
Data Augmentation ◽  
Domain Adaptation ◽  
Learning Model ◽  
Frequency Noise ◽  
Nonlinear Mapping ◽  
Intelligent Fault Diagnosis ◽  
Deep Learning Model ◽  
Adaptation Ability

Intelligent fault diagnosis techniques have replaced the time-consuming and unreliable human analysis, increasing the efficiency of fault diagnosis. Deep learning model can improve the accuracy of intelligent fault diagnosis with the help of its multilayer nonlinear mapping ability. This paper has proposed a novel method named Deep Convolutional Neural Networks with Wide First-layer Kernels (WDCNN). The proposed method uses raw vibration signals as input (data augmentation is used to generate more inputs), and uses the wide kernels in first convolutional layer for extracting feature and suppressing high frequency noise. Small convolutional kernels in the preceding layers are used for multilayer nonlinear mapping. AdaBN is implemented to improve the domain adaptation ability of the model. The proposed model addresses the problem that currently, the accuracy of CNN applied to fault diagnosis is not very high. WDCNN can not only achieve 100% classification accuracy on normal signals, but also outperform state of the art DNN model which is based on frequency features under different working load and noisy environment.

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