scholarly journals Defective intestinal repair after short-term high fat diet due to loss of efferocytosis

2019 ◽  
Author(s):  
Andrea A. Hill ◽  
Myunghoo Kim ◽  
Daniel F. Zegarra-Ruiz ◽  
Hyo Won Song ◽  
Michael C. Renfroe ◽  
...  
Keyword(s):  
Dietary Lipids ◽  
Intestinal Damage ◽  
Intestinal Epithelial ◽  
High Fat ◽  
Short Term ◽  
Apoptotic Neutrophil ◽  
Short Term Exposure ◽  
Fat Diets ◽  
Barrier Repair ◽  
Intestinal Repair

AbstractDefective tissue repair is a hallmark of many inflammatory disorders including, inflammatory bowel disease (IBD). While it is clear that high fat diets (HFD) can exacerbate inflammatory disease by increasing inflammation, the direct effect of lipids on tissue homeostasis and repair remains undefined. We show here that short term exposure to HFD directly impairs barrier repair after intestinal epithelial damage by interfering with recognition and uptake of apoptotic neutrophils by intestinal macrophages. Apoptotic neutrophil uptake induces macrophage IL-10 production, which is lacking after intestinal damage in the context of HFD. Overexpression of IL-10 rescues repair defects after HFD treatment, but not if epithelial cells lack the IL-10 receptor, highlighting the key role of IL-10 in barrier repair. These findings demonstrate a previously unidentified mechanism by which dietary lipids directly interfere with homeostatic processes required to maintain tissue integrity.

scholarly journals Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats

2009 ◽  
Vol 25 (2) ◽  
pp. 275-284 ◽  
Author(s):  
Maximilian Bielohuby ◽  
Maiko Matsuura ◽  
Nadja Herbach ◽  
Ellen Kienzle ◽  
Marc Slawik ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Formation ◽  
Bone Mineral ◽  
High Fat ◽  
Mineral Density ◽  
Short Term ◽  
Short Term Exposure ◽  
Low Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Distinct metabolic effects following short-term exposure of different high-fat diets in male and female mice

2014 ◽  
Vol 61 (5) ◽  
pp. 457-470 ◽  
Author(s):  
Shiva PD Senthil Kumar ◽  
Minqian Shen ◽  
Elizabeth G Spicer ◽  
Ashley J Goudjo-Ako ◽  
Justin D Stumph ◽  
...  
Keyword(s):  
Metabolic Effects ◽  
High Fat ◽  
Short Term ◽  
Male And Female ◽  
Female Mice ◽  
Short Term Exposure ◽  
High Fat Diets ◽  
Fat Diets

Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet

2005 ◽  
Vol 332 (1) ◽  
pp. 142-148 ◽  
Author(s):  
Anthony G. Passerini ◽  
Congzhu Shi ◽  
Nadeene M. Francesco ◽  
Peiying Chuan ◽  
Elisabetta Manduchi ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Short Term ◽  
Short Term Exposure ◽  
Endothelial Phenotype ◽  
The Impact

Taurine supplements in high-fat diets improve survival of juvenile Monopterus albus by reducing lipid deposition and intestinal damage

Aquaculture ◽  
2022 ◽  
Vol 547 ◽  
pp. 737431
Author(s):  
Yong Shi ◽  
Lei Zhong ◽  
Huan Zhong ◽  
Junzhi Zhang ◽  
Changbao Che ◽  
...  
Keyword(s):  
Intestinal Damage ◽  
Lipid Deposition ◽  
High Fat ◽  
Monopterus Albus ◽  
High Fat Diets ◽  
Fat Diets

Dietary lipids modify receptor- and non-receptor-dependent components of alpha 1-adrenoceptor-mediated contraction

1991 ◽  
Vol 261 (6) ◽  
pp. R1465-R1469 ◽  
Author(s):  
D. D. Hodgkin ◽  
R. J. Boucek ◽  
R. E. Purdy ◽  
W. J. Pearce ◽  
I. M. Fraser ◽  
...  
Keyword(s):  
Olive Oil ◽  
Contractile Response ◽  
Corn Oil ◽  
Dietary Lipids ◽  
High Fat ◽  
Low Fat ◽  
Alpha Adrenoceptor ◽  
Abdominal Aortic ◽  
High Fat Diets ◽  
Fat Diets

Dietary lipid modulation of alpha-adrenoceptor (adrenergic receptor)- and non-adrenoceptor-mediated contractile properties of isolated rat abdominal aortic segments were assessed during the early developmental period. Rats were raised from conception to 90 days of age on semisynthetic diets containing various types and amounts of lipids. Aortic segments from three groups of rats fed high-fat diets (15% wt/wt) consisting of olive oil, corn oil, or lard as the sole lipid sources were compared with those from rats fed a low-fat control diet containing corn oil (5% wt/wt). alpha-Adrenoceptor activities were assessed by measuring the norepinephrine dose response of the tissue rings with and without partial inactivation of alpha-receptors by benextramine. alpha-Adrenoceptor sensitivity to norepinephrine increased, whereas receptor affinity decreased significantly in rats raised on high-fat diets. Qualitative features of dietary lipids influenced non-adrenoceptor-dependent aspects of vascular contractility. Diets rich in polyunsaturated fatty acids (high- and low-fat corn oil) raised the maximum response to norepinephrine and the contractile response to 60 mM potassium compared with more-saturated diets (olive oil and lard). These results demonstrate an effect of chronic feeding of high dietary fat on alpha-adrenoceptor-mediated contractility of abdominal aortic rings from young Sprague-Dawley rats. Qualitative features of dietary lipids also appear to modify receptor-independent parameters of the contractile response of the arterial tissue rings in these animals.

scholarly journals Diet-induced obese mice are resistant to improvements in cardiac function resulting from short-term adropin treatment

2021 ◽  
Author(s):  
Dharendra Thapa ◽  
Bingxian Xie ◽  
Bellina AS Mushala ◽  
Manling Zhang ◽  
Janet R Manning ◽  
...  
Keyword(s):  
Cardiac Function ◽  
High Fat Diet ◽  
Contractile Function ◽  
Ex Vivo ◽  
Obese Mice ◽  
High Fat ◽  
Short Term ◽  
Neonatal Cardiomyocytes ◽  
Low Fat Diet ◽  
Short Term Exposure

Previous studies have shown that treatment with recombinant adropin, a circulating peptide secreted by the liver and brain, restores glucose utilization in the hearts of diet-induced obese mice. This restoration of fuel substrate flexibility, which is lost in obese and diabetic animals, has the potential to improve contractile function in the diabetic heart. Using an ex vivo approach, we examined whether short-term adropin treatment could enhance cardiac function in a mouse model of diet-induced obesity. Our study showed that acute adropin treatment reduces inhibitory phosphorylation of pyruvate dehydrogenase in primary neonatal cardiomyocytes, and leads to moderate improvements in ex vivo cardiac function in mice fed a low fat diet. Conversely, short-term exposure to adropin led to a small decrease in cardiac function in mice fed a long-term high fat diet. Insulin treatment did not significantly alter cardiac function in adropin treated hearts from either low or high fat diet mice, however acute adropin treatment did moderately restore downstream insulin signaling in high fat diet fed mice. Overall, these data suggest that in an ex vivo setting, acute adropin treatment alone is not sufficient to promote improved cardiac function in obese animals.

Determinants of high-fat diet hyperphagia: experimental dissection of orosensory and postingestive effects

1995 ◽  
Vol 269 (1) ◽  
pp. R30-R37 ◽  
Author(s):  
Z. S. Warwick ◽  
H. P. Weingarten
Keyword(s):  
High Fat Diet ◽  
Caloric Intake ◽  
Oral Feeding ◽  
Laboratory Animals ◽  
High Fat ◽  
Short Term ◽  
Sham Feeding ◽  
High Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

High-fat diets often promote greater caloric intake and/or weight gain than high-carbohydrate diets in both laboratory animals and humans. Because altering the fat content of a diet simultaneously changes both its sensory properties and postingestive effects, it is unclear whether high-fat hyperphagia is due to the diet's palatability, its postingestive effects, or both. The present studies isolated the independent capacity of the orosensory and postingestive effects of a liquid high-fat diet (High-Fat) to produce overeating relative to an isocaloric liquid high-carbohydrate (High-CHO) diet. Rats fed High-Fat orally ate more calories and gained more weight over 16 days than rats fed High-CHO orally. One-bottle sham-feeding intake of High-Fat and High-CHO did not differ, but in two-bottle sham-feeding tests High-Fat was clearly preferred. When orosensory influences on intake were equated via chronic self-regulated intragastric feeding, High-Fat still promoted greater intake than High-CHO, although absolute intake across both diets was lower during intragastric feeding relative to oral feeding. An analysis of short-term intake revealed that rats accustomed to infusion of High-CHO increased meal size immediately when switched to High-Fat. The present results, coupled with previous findings, suggest that the postingestive effects of fat enhance daily caloric intake in two ways: 1) during a meal, fat produces less suppression of intake per calorie than carbohydrate; and 2) after a meal, fat produces less suppression of intake per calorie during the intermeal interval than carbohydrate.

Effect of short-term low- and high-fat diets on low-density lipoprotein particle size in normolipidemic subjects

Metabolism ◽  
2012 ◽  
Vol 61 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Valérie Guay ◽  
Benoît Lamarche ◽  
Amélie Charest ◽  
André J. Tremblay ◽  
Patrick Couture
Keyword(s):  
Particle Size ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
High Fat ◽  
Short Term ◽  
Lipoprotein Particle ◽  
High Fat Diets ◽  
Lipoprotein Particle Size ◽  
Fat Diets
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