scholarly journals First Complete Genome Sequence of the Novel Lineage G-IX (BD-18) of FMDV Serotype Asia1

2019 ◽  
Author(s):  
A. S. M. Rubayet Ul Alam ◽  
M. Rahmat Ali ◽  
Md. Al Amin ◽  
Mohammad Anwar Siddique ◽  
Munawar Sultana ◽  
...  
Keyword(s):  
Complete Genome ◽  
Indian Subcontinent ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype A ◽  
Fmdv Serotype ◽  
Geographical Regions ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

ABSTRACTFoot-and-Mouth Disease (FMD) has been a major threat to livestock worldwide, and is caused by FMD Virus (FMDV) existing as seven serotypes (A, O, C, Asia1 and SAT 1-3), each having variability into topotypes, genetic lineages, sublineages, and strains. Three serotypes are circulating in Indian subcontinent with the widespread distribution of serotype O, whereas serotype A and Asia1 are restricted to certain geographical regions. During 2017-2018, the Sindh-08 lineages of Asia1 serotype was reported from Pakistan, however, in 2018, a novel circulatory foot-and-mouth disease virus serotype Asia1 BD-18 (G-IX) lineage containing a unique mutation has emerged in Bangladesh. The first complete genome of the Asia1/ASIA/G-IX novel lineage strain, isolated from Bangladesh, is reported here. Amino acid substitutions at critical antigenic sites of capsid were identified compared to genome of existing vaccine strain (IND/63/72), and contemporary FMDV serotype A isolate of Bangladesh.

scholarly journals Use of ENABL® adjuvant to increase the potency of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine

Vaccine ◽  
2018 ◽  
Vol 36 (8) ◽  
pp. 1078-1084 ◽  
Author(s):  
José Barrera ◽  
Christopher Schutta ◽  
Melia Pisano ◽  
Marvin J. Grubman ◽  
David A. Brake ◽  
...  
Keyword(s):  
Disease Virus ◽  
Subunit Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
A Subunit

scholarly journals Near-Complete Genome Sequence of a Potential Foot-and-Mouth Disease Virus Serotype A Vaccine Strain Isolated from Bangladesh

2019 ◽  
Vol 8 (37) ◽  
Author(s):  
M. Al Amin ◽  
M. Rahmat Ali ◽  
A. S. M. Rubayet Ul Alam ◽  
Mohammad Anwar Siddique ◽  
Huzzat Ullah ◽  
...  
Keyword(s):  
Disease Virus ◽  
Vaccine Strain ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Foot And Mouth

The near-complete genome sequence of foot-and-mouth disease virus (FMDV) serotype A potential vaccine strain BAN/CH/Sa-304/2016 is reported here. Its genome revealed antigenic heterogeneity with the current Indian vaccine strain IND40/00, with four amino acid substitutions in antigenically critical sites of the VP1 protein.

scholarly journals Cell culture adaptation mutations in foot-and-mouth disease virus serotype A capsid proteins: implications for receptor interactions

2015 ◽  
Vol 96 (3) ◽  
pp. 553-564 ◽  
Author(s):  
Jajati K. Mohapatra ◽  
Laxmi K. Pandey ◽  
Devendra K. Rai ◽  
Biswajit Das ◽  
Luis L. Rodriguez ◽  
...  
Keyword(s):  
Cell Culture ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Capsid Proteins ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Receptor Interactions ◽  
Foot And Mouth

scholarly journals Generation of mAbs to foot–and–mouth disease virus serotype A and application in a competitive ELISA for serodiagnosis

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Ming Yang ◽  
Wanhong Xu ◽  
Hilary Bittner ◽  
Jacquelyn Horsington ◽  
Wilna Vosloo ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Competitive Elisa ◽  
Mouth Disease ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

scholarly journals Molecular detection, phylogenetic analysis and genetic diversity of recently isolated foot-and-mouth disease virus serotype A African topotype, Genotype IV

2022 ◽  
Vol 19 (1) ◽  
Author(s):  
Ayah M. Hassan ◽  
Mostafa R. Zaher ◽  
Rabab T. Hassanien ◽  
Mervat I. Abd-El-Moniem ◽  
Ahmed R. Habashi ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Emerging Diseases ◽  
Mouth Disease ◽  
Control Measures ◽  
Close Monitoring ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

Abstract Background Surveillance for circulating emerging diseases of economic importance has a major role in the rapid response to major pathogen outbreaks. Foot-and-mouth disease virus (FMDV) is one of the significant endemic viruses in Egypt. FMDV is periodically investigated for monitoring evolution and emergence of new variants. The genetic characterization of foot-and-mouth disease (FMD) virus serotype A responsible for recent outbreaks of FMD in Egypt was determined. Methods Samples were collected from different locations and virus isolation was performed using BHK-21 cells. Viral RNA was extracted and samples were screened for FMDV using real-time RT-PCR. DNA sequence analysis was performed and computational and bioinformatics analyses were used to determine the substitution rates and phylogenetic relationship. Results Sequence and phylogenetic analyses of full-length 1D region of FMDV samples collected from different governorates in 2020 showed close similarity to Egyptian FMDV strains from serotype A-African topotype-G-IV with genetic variation of 6.5%. Recently isolated FMDV strains showed high genetic variations from locally used vaccine strains in the major antigenic sites of VP1 region. Conclusions Although, efforts made by the veterinary authorities to implement an effective mass vaccination plan, the recently detected FMDV strains in this study could not be subtyped using the FMDV primers routinely used for molecular serotyping. These dissimilarities raise the alarm for reconsideration of the FMDV isolates used in vaccine manufacture. Clearly close monitoring of FMD in Egypt is urgently required to define the risks of future outbreaks and to ensure appropriate control measures against FMD major outbreaks.

scholarly journals Complete Genome Sequence of Foot-and-Mouth Disease Virus Serotype O Strain YNTBa from Yunnan Province of China

2017 ◽  
Vol 5 (22) ◽  
Author(s):  
Huan Yan ◽  
Jihua Wang ◽  
Mingwang Zhu ◽  
Haisheng Miao ◽  
Zhenqi Peng ◽  
...  
Keyword(s):  
Disease Virus ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

ABSTRACT YNTBa is a rabbit-passaged attenuated strain of foot-and-mouth disease virus (FMDV) serotype O. Here, we announce the complete genome sequence of YNTBa, which provides data for further studies on replication, virulence, its determinants, and cell and host tropism of YNTBa.

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